The article discusses the early abandonment of mechanical theories about eye enlargement in degenerative myopia at the turn of the 20th century.At that time,the number of theories about myopia grew unrestricted,but wi...The article discusses the early abandonment of mechanical theories about eye enlargement in degenerative myopia at the turn of the 20th century.At that time,the number of theories about myopia grew unrestricted,but with scant support from the experimental field.The mechanical theories vanished as a new wave of metabolism-based theories appeared,propelled by the huge advances in molecular biology.Modern techniques allow reconsidering those theories and to put them to test with higher confidence.展开更多
AIM:To explore the diagnostic performance of isolatedcheck visual evoked potential(ic VEP)for primary open angle glaucoma(POAG)in both highly myopic and nonhighly myopic populations and compare it with those of optica...AIM:To explore the diagnostic performance of isolatedcheck visual evoked potential(ic VEP)for primary open angle glaucoma(POAG)in both highly myopic and nonhighly myopic populations and compare it with those of optical coherence tomography(OCT)and Heidelberg retinal tomography(HRT)parameters.METHODS:A total of 126 participants were recruited,including 31 highly myopic participants with POAG(HM-POAG),36 non-highly myopic participants with POAG(NHM-POAG),25 highly myopic participants without POAG(HM)and 34 controls without high myopia(Normal).All the participants underwent a complete ophthalmic examination.The signal-to-noise ratio(SNR)was used to assess the ic VEP.Both qualitative and quantitative diagnostic performances of OCT,HRT and the ic VEP were analyzed and compared.RESULTS:Based on the criterion of SNR≤1,the diagnostic performance of the ic VEP in highly myopic subjects[area under the receiver operating characteristic curve(AUC)=0.862]was better than that in non-highly myopic subjects(AUC=0.789),and the SNR had fairly good specificity.In distinguishing the HM-POAG and HM groups,the AUC of the SNR was not different from those of the OCT and HRT parameters(P>0.05)in either the qualitative or quantitative comparison.In the qualitative analysis,the ic VEP showed good consistency with damage to the central 10°of the visual field(kappa=0.695-0.747,P<0.001).CONCLUSION:The ic VEP has the potential to discriminate individuals with and without POAG,especially in populations with high myopia.展开更多
Functional imaging may be useful for both the early diagnosis as well as preclinical detection of neurodegenerative disease.Additionally,while structural imaging has traditionally been regarded as a tool to exclude al...Functional imaging may be useful for both the early diagnosis as well as preclinical detection of neurodegenerative disease.Additionally,while structural imaging has traditionally been regarded as a tool to exclude alternate diagnoses,recent advances in magnetic resonance show promise for greater diagnostic specificity.The role of MR and radionuclide imaging in early diagnosis and preclinical detection of dementia and parkinsonism are reviewed here.展开更多
文摘The article discusses the early abandonment of mechanical theories about eye enlargement in degenerative myopia at the turn of the 20th century.At that time,the number of theories about myopia grew unrestricted,but with scant support from the experimental field.The mechanical theories vanished as a new wave of metabolism-based theories appeared,propelled by the huge advances in molecular biology.Modern techniques allow reconsidering those theories and to put them to test with higher confidence.
文摘AIM:To explore the diagnostic performance of isolatedcheck visual evoked potential(ic VEP)for primary open angle glaucoma(POAG)in both highly myopic and nonhighly myopic populations and compare it with those of optical coherence tomography(OCT)and Heidelberg retinal tomography(HRT)parameters.METHODS:A total of 126 participants were recruited,including 31 highly myopic participants with POAG(HM-POAG),36 non-highly myopic participants with POAG(NHM-POAG),25 highly myopic participants without POAG(HM)and 34 controls without high myopia(Normal).All the participants underwent a complete ophthalmic examination.The signal-to-noise ratio(SNR)was used to assess the ic VEP.Both qualitative and quantitative diagnostic performances of OCT,HRT and the ic VEP were analyzed and compared.RESULTS:Based on the criterion of SNR≤1,the diagnostic performance of the ic VEP in highly myopic subjects[area under the receiver operating characteristic curve(AUC)=0.862]was better than that in non-highly myopic subjects(AUC=0.789),and the SNR had fairly good specificity.In distinguishing the HM-POAG and HM groups,the AUC of the SNR was not different from those of the OCT and HRT parameters(P>0.05)in either the qualitative or quantitative comparison.In the qualitative analysis,the ic VEP showed good consistency with damage to the central 10°of the visual field(kappa=0.695-0.747,P<0.001).CONCLUSION:The ic VEP has the potential to discriminate individuals with and without POAG,especially in populations with high myopia.
文摘Functional imaging may be useful for both the early diagnosis as well as preclinical detection of neurodegenerative disease.Additionally,while structural imaging has traditionally been regarded as a tool to exclude alternate diagnoses,recent advances in magnetic resonance show promise for greater diagnostic specificity.The role of MR and radionuclide imaging in early diagnosis and preclinical detection of dementia and parkinsonism are reviewed here.
