Objective To compare the pathogenicity of isolates of sequence type 7(ST-7)Neisseria meningitidis(N.meningitidis)belonging to four different serogroups(A,B,C,and X).Methods Four ST-7 N.meningitidis isolates serogroupe...Objective To compare the pathogenicity of isolates of sequence type 7(ST-7)Neisseria meningitidis(N.meningitidis)belonging to four different serogroups(A,B,C,and X).Methods Four ST-7 N.meningitidis isolates serogrouped as A,B,C,and X and characterized by different capsule structures,were examined for their adhesion and invasion properties,and their ability to induce cytokine release and apoptosis in the host cell(the A549 cell line).Results Among the four ST-7 N.meningitidis isolates,the serogroup A isolate possessed the strongest adhesion and invasion ability.This isolate also induced the release of the highest levels of the proinflammatory mediators interleukin-6,interleukin-1β,and interferon,and the highest apoptosis rate in the host cells.However,there was no significant difference in interleukin-8 and tumor necrosis factor-αsecretion between the four isolates.Based on the findings,the serogroup X N.meningitidis isolate had the weakest pathogenicity,whereas there was almost no difference in the pathogenicity of the isolates from serogroups B and C.Conclusions The differences in the capsular structure of the four isolates of ST-7 N.meningitidis affected their pathogenic capacities.The findings also imply that the hyperinvasive ST-7 N.meningitidis lineage may include hypoinvasive isolates.展开更多
Objective: To explore the protective effect of Baoyuan Qiangshen Capsule No. Ⅱ (BYQS) and its mechanism in treating chronic renal failure (CRF). Methods: Sixty CRF patients were divided into 2 groups randomly, the tr...Objective: To explore the protective effect of Baoyuan Qiangshen Capsule No. Ⅱ (BYQS) and its mechanism in treating chronic renal failure (CRF). Methods: Sixty CRF patients were divided into 2 groups randomly, the treated group used BYQS combined with Lotensin and the control group administered with essential amino acid combined with Lotensin. Changes of renal functions and tubular labelled proteins were observed. Results: The markedly effective rate and total effective rate of the treated group were 63.3% and 93.3% respectively, and those of the control group were 30.0% and 56.7% respectively, the effect of the treated group was obviously better than that of the control group ( P <0.01). In the treated group after medication, blood urea nitrogen, serum creatinine and clearance rate of creatinine were improved significantly ( P <0.01), while Tamm Horfau protein increased significantly ( P <0.01). Conclusion: BYQS could alleviate tubular interstitial injury significantly so as to improve the renal function and enhance the effective rate in treating CRF.展开更多
Near 50 years history of the development of radioisotope neutron sources in China is briefly reviewed.The structure design,preparing technology and production status of routine neutron sources including 210Po-Be sourc...Near 50 years history of the development of radioisotope neutron sources in China is briefly reviewed.The structure design,preparing technology and production status of routine neutron sources including 210Po-Be sources,210Po mock fission sources,241Am-Be sources,238Pu-Be sources,252Cf spontaneous fission sources and other special-shape neutron sources are summarized.In addition,the prospects of development on radioisotope neutron source in China are predicted from the needs of nuclear power construction,oil well-logging,neutron moisture gauge and neutron brachytherapy.展开更多
基金supported by the grants from the National Key Program for Infectious Disease of China[No.2018ZX10101002-001-014]the National Natural Scientific Foundation[No.81602903]+1 种基金the Ministry of Science and Technology of the People’s Republic of Chinathe Sanming Project of Medicine in Shenzhen[No.SZSM201803081].
文摘Objective To compare the pathogenicity of isolates of sequence type 7(ST-7)Neisseria meningitidis(N.meningitidis)belonging to four different serogroups(A,B,C,and X).Methods Four ST-7 N.meningitidis isolates serogrouped as A,B,C,and X and characterized by different capsule structures,were examined for their adhesion and invasion properties,and their ability to induce cytokine release and apoptosis in the host cell(the A549 cell line).Results Among the four ST-7 N.meningitidis isolates,the serogroup A isolate possessed the strongest adhesion and invasion ability.This isolate also induced the release of the highest levels of the proinflammatory mediators interleukin-6,interleukin-1β,and interferon,and the highest apoptosis rate in the host cells.However,there was no significant difference in interleukin-8 and tumor necrosis factor-αsecretion between the four isolates.Based on the findings,the serogroup X N.meningitidis isolate had the weakest pathogenicity,whereas there was almost no difference in the pathogenicity of the isolates from serogroups B and C.Conclusions The differences in the capsular structure of the four isolates of ST-7 N.meningitidis affected their pathogenic capacities.The findings also imply that the hyperinvasive ST-7 N.meningitidis lineage may include hypoinvasive isolates.
文摘Objective: To explore the protective effect of Baoyuan Qiangshen Capsule No. Ⅱ (BYQS) and its mechanism in treating chronic renal failure (CRF). Methods: Sixty CRF patients were divided into 2 groups randomly, the treated group used BYQS combined with Lotensin and the control group administered with essential amino acid combined with Lotensin. Changes of renal functions and tubular labelled proteins were observed. Results: The markedly effective rate and total effective rate of the treated group were 63.3% and 93.3% respectively, and those of the control group were 30.0% and 56.7% respectively, the effect of the treated group was obviously better than that of the control group ( P <0.01). In the treated group after medication, blood urea nitrogen, serum creatinine and clearance rate of creatinine were improved significantly ( P <0.01), while Tamm Horfau protein increased significantly ( P <0.01). Conclusion: BYQS could alleviate tubular interstitial injury significantly so as to improve the renal function and enhance the effective rate in treating CRF.
文摘Near 50 years history of the development of radioisotope neutron sources in China is briefly reviewed.The structure design,preparing technology and production status of routine neutron sources including 210Po-Be sources,210Po mock fission sources,241Am-Be sources,238Pu-Be sources,252Cf spontaneous fission sources and other special-shape neutron sources are summarized.In addition,the prospects of development on radioisotope neutron source in China are predicted from the needs of nuclear power construction,oil well-logging,neutron moisture gauge and neutron brachytherapy.
