The mechanism of the reaction of N β dydroxyethylethylenediamine (HEDA) on copper under catalysis for the synthesis of piperazine was studied.The structures of reaction mixtures were identified by GC MS.The prelimina...The mechanism of the reaction of N β dydroxyethylethylenediamine (HEDA) on copper under catalysis for the synthesis of piperazine was studied.The structures of reaction mixtures were identified by GC MS.The preliminary study demonstrats that the above reaction is an intermolecular catalytic amination of alcohol and was proved to proceed through dehydrogenation and hydrogenation.Under the reaction conditions HEDA may undertake the bimolecular disproportionation reaction.Furthermore,the similar nucleophilic substitution reactions between starting material and products,between products and products,possibly occur to give the corresponding byproducts.展开更多
文摘The mechanism of the reaction of N β dydroxyethylethylenediamine (HEDA) on copper under catalysis for the synthesis of piperazine was studied.The structures of reaction mixtures were identified by GC MS.The preliminary study demonstrats that the above reaction is an intermolecular catalytic amination of alcohol and was proved to proceed through dehydrogenation and hydrogenation.Under the reaction conditions HEDA may undertake the bimolecular disproportionation reaction.Furthermore,the similar nucleophilic substitution reactions between starting material and products,between products and products,possibly occur to give the corresponding byproducts.
文摘以三乙醇胺和氯化亚砜为原料,在N,N-二甲基甲酰胺(DMF)溶剂中经氯代反应合成中间体三(2-氯乙基)胺盐酸盐,然后与过量的氨水在乙醇溶剂中经氨解反应,得N,N-二(2-氨乙基)-1,2-乙二胺.优化实验得出N,N-二(2-氨乙基)-1,2-乙二胺合成反应原料氨水与中间体三(2-氯乙基)胺盐酸盐的最佳摩尔比为30,最佳反应温度为65℃,最优反应时间不低于12 h.
