N,N-Diisopropylethanoamine was synthesized from diisopropylamine and ethylene oxide,and then chloridized to N,N-diisopropyl-2-aminoethyl chloride,which finally went through amindysis in benzene to(produce) the title p...N,N-Diisopropylethanoamine was synthesized from diisopropylamine and ethylene oxide,and then chloridized to N,N-diisopropyl-2-aminoethyl chloride,which finally went through amindysis in benzene to(produce) the title product N,N-diisopropyl ethanediamine.In these reactions,the optimum molar ratios were 1.2∶[KG-*3/5]1 for ethylene oxide to diisopropylamine,2∶[KG-*3/5]1 for thionyl chloride to N,N-diisoproylethanoamine,and(12∶[KG-*3/5]1) for ammonia to N,N-diisopropyl-2-aminoethyl chloride,respectively.The suitable reaction time,temperature,and solvent were also discussed.The total yield of 81.4% was obtained for the title product.展开更多
A highly efficient three-component reaction has been developed for the synthesis of thiazolidinones involving the reaction of 2-amino-l-phenylethanone hydrochloride with an aromatic aldehyde and mercaptoacetic acid in...A highly efficient three-component reaction has been developed for the synthesis of thiazolidinones involving the reaction of 2-amino-l-phenylethanone hydrochloride with an aromatic aldehyde and mercaptoacetic acid in the presence of diisopropylethylamine in a single pot.Critically,this reaction exhibited excellent chemoselectivity,with the nitrogen atom of the 2-amino-l-phenylethanone component reacting selectively with the aromatic aldehyde to give the corresponding Schiff base.Nucleophilic attack at the carbon of the Schiff base by the sulfur atom of mercaptoacetic,followed by a cyclocondensation reaction between the nitrogen and the carboxylic acid moiety afforded the desired thiazolidinones,which were fully characterized by spectroscopic techniques.展开更多
文摘N,N-Diisopropylethanoamine was synthesized from diisopropylamine and ethylene oxide,and then chloridized to N,N-diisopropyl-2-aminoethyl chloride,which finally went through amindysis in benzene to(produce) the title product N,N-diisopropyl ethanediamine.In these reactions,the optimum molar ratios were 1.2∶[KG-*3/5]1 for ethylene oxide to diisopropylamine,2∶[KG-*3/5]1 for thionyl chloride to N,N-diisoproylethanoamine,and(12∶[KG-*3/5]1) for ammonia to N,N-diisopropyl-2-aminoethyl chloride,respectively.The suitable reaction time,temperature,and solvent were also discussed.The total yield of 81.4% was obtained for the title product.
基金supported by Special Assistance Programme SAP,University Grants Commission,New Delhi,India
文摘A highly efficient three-component reaction has been developed for the synthesis of thiazolidinones involving the reaction of 2-amino-l-phenylethanone hydrochloride with an aromatic aldehyde and mercaptoacetic acid in the presence of diisopropylethylamine in a single pot.Critically,this reaction exhibited excellent chemoselectivity,with the nitrogen atom of the 2-amino-l-phenylethanone component reacting selectively with the aromatic aldehyde to give the corresponding Schiff base.Nucleophilic attack at the carbon of the Schiff base by the sulfur atom of mercaptoacetic,followed by a cyclocondensation reaction between the nitrogen and the carboxylic acid moiety afforded the desired thiazolidinones,which were fully characterized by spectroscopic techniques.
