Nitrophenyl ferulate was synthesized in one step without the protection of the hydroxyl of ferulic acid in the presence of 1,3 dicyclohexylcarbodiimide(DCC) as the catalyst. Thus, 15 20 g of ferulic acid reacted with ...Nitrophenyl ferulate was synthesized in one step without the protection of the hydroxyl of ferulic acid in the presence of 1,3 dicyclohexylcarbodiimide(DCC) as the catalyst. Thus, 15 20 g of ferulic acid reacted with 18 07 g of 4 nitrophenol for 24 h at room temperature in the presence of 22 44 g of DCC. The crude product was recrystallized from CHCl 3 to give 16 00 g of 4 nitrophenyl ferulate and the yield was 82 5%. Elemental analysis, IR and 1H NMR techniques were used to prove the structure of the product.展开更多
N-glycinylmaleamic acid(GMA) was synthesized by using maleic anhydride and glycine.Five synthesis methods for N-glycinylmaleimide(GMI)were compared.Among them the method using triethylamine to dehydrate was found to b...N-glycinylmaleamic acid(GMA) was synthesized by using maleic anhydride and glycine.Five synthesis methods for N-glycinylmaleimide(GMI)were compared.Among them the method using triethylamine to dehydrate was found to be the best.Their structures were confirmed by fourier transform infrared spectroscopy(FTIR) and nuclear magnetic resonance spectrum(HNMR).展开更多
N-取代马来酰亚胺是重要的有机合成与高分子合成的中间体.采用呋喃保护的马来酸酐为原料,在碱性条件下和氨基乙醇反应得到呋喃N-羟乙基马来酰亚胺,最后用高沸点溶剂加热脱去呋喃环,得到N-羟乙基马来酰亚胺,总收率达64.1%.同时对各步反...N-取代马来酰亚胺是重要的有机合成与高分子合成的中间体.采用呋喃保护的马来酸酐为原料,在碱性条件下和氨基乙醇反应得到呋喃N-羟乙基马来酰亚胺,最后用高沸点溶剂加热脱去呋喃环,得到N-羟乙基马来酰亚胺,总收率达64.1%.同时对各步反应条件进行了优化.所得中间体和目标化合物经过1 H NMR和13C NMR进行了表征.展开更多
基金supported by the National Natural Science Foundation of China(21376208)the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China(LR13B030001)+2 种基金the Specialized Research Fund for the Doctoral Program of Higher Education(J20130060)the Fundamental Research Funds for the Central Universitiesthe Program for Zhejiang Leading Team of S&T Innovation~~
文摘Nitrophenyl ferulate was synthesized in one step without the protection of the hydroxyl of ferulic acid in the presence of 1,3 dicyclohexylcarbodiimide(DCC) as the catalyst. Thus, 15 20 g of ferulic acid reacted with 18 07 g of 4 nitrophenol for 24 h at room temperature in the presence of 22 44 g of DCC. The crude product was recrystallized from CHCl 3 to give 16 00 g of 4 nitrophenyl ferulate and the yield was 82 5%. Elemental analysis, IR and 1H NMR techniques were used to prove the structure of the product.
文摘N-glycinylmaleamic acid(GMA) was synthesized by using maleic anhydride and glycine.Five synthesis methods for N-glycinylmaleimide(GMI)were compared.Among them the method using triethylamine to dehydrate was found to be the best.Their structures were confirmed by fourier transform infrared spectroscopy(FTIR) and nuclear magnetic resonance spectrum(HNMR).
文摘N-取代马来酰亚胺是重要的有机合成与高分子合成的中间体.采用呋喃保护的马来酸酐为原料,在碱性条件下和氨基乙醇反应得到呋喃N-羟乙基马来酰亚胺,最后用高沸点溶剂加热脱去呋喃环,得到N-羟乙基马来酰亚胺,总收率达64.1%.同时对各步反应条件进行了优化.所得中间体和目标化合物经过1 H NMR和13C NMR进行了表征.
