N-正丁基-1-脱氧野尻霉素的合成

N-butyl-1-deoxynojirimycin(Zavesca) is an important glucosidase inhibitor,which is a kind of azasugar,which is synthesized from glucose,followed by oxidation,amination,reduction and deprotection etc.The structure of target compound is confirmed by 1H NMR.

N-正丁基-1-脱氧野尻霉素合成方法的改进

目的改进N-正丁基-1-脱氧野尻霉素的合成方法。方法该文通过酰化反应分别用丁酰氯和丁酸酐将丁酰基引入到2,3,4,6四-苄基葡萄糖内酰胺的氮原子上,然后用氢化铝锂将两个羰基还原,得到N-正丁基-2,3,4,6四-苄基-1脱-氧野尻霉素。结果与结论该方法在改进部分将收率提高为相关文献的2～3倍,在氨解开环这一步,尝试用正丁基胺代替饱和氨气的甲醇溶液,并对其关环产物以及副产物的生成机制进行了探讨。