[目的]制备多种酰胺类农药的一个重要中间体N-羟甲基-2-三氟甲基苯甲酰胺。[方法]以邻三氟甲基苯甲醛为起始原料,经氧化反应得到邻三氟甲基苯甲酸,然后与氯化亚砜、氨气经氯化及胺化得到邻三氟甲基苯甲酰胺,最后经羟甲基化得到N-羟甲基...[目的]制备多种酰胺类农药的一个重要中间体N-羟甲基-2-三氟甲基苯甲酰胺。[方法]以邻三氟甲基苯甲醛为起始原料,经氧化反应得到邻三氟甲基苯甲酸,然后与氯化亚砜、氨气经氯化及胺化得到邻三氟甲基苯甲酰胺,最后经羟甲基化得到N-羟甲基-2-三氟甲基苯甲酰胺。目标化合物及中间体结构经1H N M R确证。[结果]反应总收率66.6%,产品含量98.5%。[结论]该工艺收率高,操作简单,可为工业化生产提供参考。展开更多
The catalytic performance of a series of cobalt(Ⅱ) hydroxamates (CoL2) and the synergistic catalytic action of the cobalt complexes combined with N-hydroxyphthalimide (NHPI) in the aerobic oxidation of p-xylene to p-...The catalytic performance of a series of cobalt(Ⅱ) hydroxamates (CoL2) and the synergistic catalytic action of the cobalt complexes combined with N-hydroxyphthalimide (NHPI) in the aerobic oxidation of p-xylene to p-toluic acid (PTA) were investigated. The results showed that the existing synergistic action in the catalytic oxidation can shorten the induction period of the radical reaction and improve the yield of PTA.展开更多
文摘[目的]制备多种酰胺类农药的一个重要中间体N-羟甲基-2-三氟甲基苯甲酰胺。[方法]以邻三氟甲基苯甲醛为起始原料,经氧化反应得到邻三氟甲基苯甲酸,然后与氯化亚砜、氨气经氯化及胺化得到邻三氟甲基苯甲酰胺,最后经羟甲基化得到N-羟甲基-2-三氟甲基苯甲酰胺。目标化合物及中间体结构经1H N M R确证。[结果]反应总收率66.6%,产品含量98.5%。[结论]该工艺收率高,操作简单,可为工业化生产提供参考。
基金supported by the National Natural Science Foundation of China(Grant No.20072025).
文摘The catalytic performance of a series of cobalt(Ⅱ) hydroxamates (CoL2) and the synergistic catalytic action of the cobalt complexes combined with N-hydroxyphthalimide (NHPI) in the aerobic oxidation of p-xylene to p-toluic acid (PTA) were investigated. The results showed that the existing synergistic action in the catalytic oxidation can shorten the induction period of the radical reaction and improve the yield of PTA.
