As a synergistic anti tumor agent, N solanesyl N,N ′ bis(3,4 dimethoxybenzyl)ethylenediamine(5) was synthesized starting from vanillin and solanesol. Methylation of vanillin gave veratradehyde(1), which after couplin...As a synergistic anti tumor agent, N solanesyl N,N ′ bis(3,4 dimethoxybenzyl)ethylenediamine(5) was synthesized starting from vanillin and solanesol. Methylation of vanillin gave veratradehyde(1), which after coupling with ethylenediamine was then catalytically reduced to N,N ′ bis(3,4 dimethoxybenzyl)ethylenediamine(3), which was coupled with solanesol bromide (4) to give (5). The processes of synthesis of (3) and separation of (5) have been improved with total reaction yield being increased. The structures of the compounds were confirmed by IR, 1 H NMR, MS and elemental analysis.展开更多
文摘As a synergistic anti tumor agent, N solanesyl N,N ′ bis(3,4 dimethoxybenzyl)ethylenediamine(5) was synthesized starting from vanillin and solanesol. Methylation of vanillin gave veratradehyde(1), which after coupling with ethylenediamine was then catalytically reduced to N,N ′ bis(3,4 dimethoxybenzyl)ethylenediamine(3), which was coupled with solanesol bromide (4) to give (5). The processes of synthesis of (3) and separation of (5) have been improved with total reaction yield being increased. The structures of the compounds were confirmed by IR, 1 H NMR, MS and elemental analysis.
