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Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties 被引量:2
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作者 Hao Tang Jin Tang +6 位作者 Yi Shen Wen-Xuan Guo Min Zhou Rui-Hua Wang Ni Jiang Zhi-Hua Gan Qing-Song Yu 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2018年第11期1225-1238,共14页
The synthesis and structure-property correlation of poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA) conjugates with various architectures including random, block, branched or star-like structures and compositio... The synthesis and structure-property correlation of poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA) conjugates with various architectures including random, block, branched or star-like structures and compositions have been thoroughly explored. However, related synthesis and structure-property data are still lacking for comb-like PHPMA. In this work, we report the synthesis of comb-like PHPMA copolymer-doxorubicin (DOX) conjugates with different backbone/side-chain lengths and location of drug moieties. Well-defined comb-like PHPMA-DOX conjugates are obtained via the combination of controlled radical polymerization and fractional precipitation techniques. The influences of structural factors on the biological properties such as cellular uptake, blood circulation and tumor accumulation have been investigated. Long blood circulation and efficient tumor accumulation can be achieved by proper control of the comb number, length and location of drug moieties. These facile comb-like structures possess great potentials in future theranostics for brachytherapy or surgical navigation. 展开更多
关键词 Poly(n-(2-hydroxypropyl) methacrylamide Comb-like copolymer Anticancer drug delivery Synthesis Structure-property correlation
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