The reaction mechanism of the intramolecular cycloaddition of N-3-butenyl nitrone has been investigated theoretically by using AM1 MO method and transition state theory.There are two parallel reactions leading to two ...The reaction mechanism of the intramolecular cycloaddition of N-3-butenyl nitrone has been investigated theoretically by using AM1 MO method and transition state theory.There are two parallel reactions leading to two different regioisomers.The ratio of the rate constants of these two reactions was calculated to be 124.1(at 383.75 K).The obtained results can be used to explain the high regiospecificity of the reaction product.展开更多
目的评估老年肌少症患者的营养状况和炎症因子,探讨n-3脂肪酸(n-3 fatty acids,n-3 PUFA)在老年肌少症患者中的作用。方法选取2020年1月至6月在湖南省人民医院老年科住院及体检科健康体检的70岁以上能行走的老年人,根据欧洲老年人肌少...目的评估老年肌少症患者的营养状况和炎症因子,探讨n-3脂肪酸(n-3 fatty acids,n-3 PUFA)在老年肌少症患者中的作用。方法选取2020年1月至6月在湖南省人民医院老年科住院及体检科健康体检的70岁以上能行走的老年人,根据欧洲老年人肌少症工作组(European working group on sarcopenia in the elderly,EWGSOP)诊断标准分为无肌少症组和肌少症组,检测入选者的营养指标,测定炎性细胞因子水平。肌少症组患者分为实验组和对照组,在高蛋白饮食[1.2g/(kg·d)]并维持营养指标正常的基础上实验组患者补充n-3 PUFA 1000mg/d,比较分析补充后炎性细胞因子水平的变化。结果肌少症组患者的外周血25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]、血钙、血磷及血红蛋白较无肌少症组降低,差异有统计学意义(P<0.05)。肌少症组患者的外周血肿瘤坏死因子α(tumornecrosisfactorα,TNF-α)、白细胞介素(interleukin,IL)-6、C反应蛋白(C-reactive protein,CRP)高于对照组,差异有统计学意义(P<0.05),补充n-3 PUFA24周后患者的TNF-α、IL-6、CRP下降,但差异无统计学意义(P>0.05)。补充n-3 PUFA 48周后患者的TNF-α、IL-6、CRP继续下降,差异有统计学意义(P<0.05),IL-10升高,差异无统计学意义(P>0.05)。结论肌少症患者的血25(OH)D、血钙、血磷及血红蛋白等营养指标减少、致炎因子增加可能是老年人肌少症的发病机制之一,补充n-3 PUFA可通过抑制炎症成为肌少症的防治手段之一。展开更多
Postprandial metabolism plays major roles in many pathological conditions.The n-6/n-3 polyunsaturated fatty acid(PUFA)ratio is closely related to various physiological disorders.This study aimed to investigate the eff...Postprandial metabolism plays major roles in many pathological conditions.The n-6/n-3 polyunsaturated fatty acid(PUFA)ratio is closely related to various physiological disorders.This study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control(NC)and hypertriglyceridemia(HTG)rats.The postprandial response of triglyceride(TG)in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio meals.The HTG groups showed higher postprandial total cholesterol(TC)responses than NC groups after 1:1 and 20:1 ratio meals.The 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factorα(TNF-α)than 1:1 and 10:1 ratios in HTG groups.The postprandial malondialdehyde(MDA)response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG groups.The 1:1 ratio resulted in a lower postprandial reactive oxygen species(ROS)level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC groups.The results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats.A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats.展开更多
文摘The reaction mechanism of the intramolecular cycloaddition of N-3-butenyl nitrone has been investigated theoretically by using AM1 MO method and transition state theory.There are two parallel reactions leading to two different regioisomers.The ratio of the rate constants of these two reactions was calculated to be 124.1(at 383.75 K).The obtained results can be used to explain the high regiospecificity of the reaction product.
文摘目的评估老年肌少症患者的营养状况和炎症因子,探讨n-3脂肪酸(n-3 fatty acids,n-3 PUFA)在老年肌少症患者中的作用。方法选取2020年1月至6月在湖南省人民医院老年科住院及体检科健康体检的70岁以上能行走的老年人,根据欧洲老年人肌少症工作组(European working group on sarcopenia in the elderly,EWGSOP)诊断标准分为无肌少症组和肌少症组,检测入选者的营养指标,测定炎性细胞因子水平。肌少症组患者分为实验组和对照组,在高蛋白饮食[1.2g/(kg·d)]并维持营养指标正常的基础上实验组患者补充n-3 PUFA 1000mg/d,比较分析补充后炎性细胞因子水平的变化。结果肌少症组患者的外周血25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]、血钙、血磷及血红蛋白较无肌少症组降低,差异有统计学意义(P<0.05)。肌少症组患者的外周血肿瘤坏死因子α(tumornecrosisfactorα,TNF-α)、白细胞介素(interleukin,IL)-6、C反应蛋白(C-reactive protein,CRP)高于对照组,差异有统计学意义(P<0.05),补充n-3 PUFA24周后患者的TNF-α、IL-6、CRP下降,但差异无统计学意义(P>0.05)。补充n-3 PUFA 48周后患者的TNF-α、IL-6、CRP继续下降,差异有统计学意义(P<0.05),IL-10升高,差异无统计学意义(P>0.05)。结论肌少症患者的血25(OH)D、血钙、血磷及血红蛋白等营养指标减少、致炎因子增加可能是老年人肌少症的发病机制之一,补充n-3 PUFA可通过抑制炎症成为肌少症的防治手段之一。
基金supported by National Key Research and Development Plan(2016YFD0400604)National Natural Science Foundation of China(82073551).
文摘Postprandial metabolism plays major roles in many pathological conditions.The n-6/n-3 polyunsaturated fatty acid(PUFA)ratio is closely related to various physiological disorders.This study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control(NC)and hypertriglyceridemia(HTG)rats.The postprandial response of triglyceride(TG)in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio meals.The HTG groups showed higher postprandial total cholesterol(TC)responses than NC groups after 1:1 and 20:1 ratio meals.The 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factorα(TNF-α)than 1:1 and 10:1 ratios in HTG groups.The postprandial malondialdehyde(MDA)response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG groups.The 1:1 ratio resulted in a lower postprandial reactive oxygen species(ROS)level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC groups.The results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats.A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats.
