Synthesis and Biological Activities of 2,4-Dichlorophenoxyacetyl(thio)urea and S-(+)-3-Methyl-2-(4-chlorophenyl)butyramide Derivatives

2,4-Dichlorophenoxyacetyl（thio）urea and S-（＋）-3-methyl-2-（4-chlorophenyl）butyramides were synthesized via acylation,aminolysis,esterification and addition reactions,and the partial new compounds have desirable bioactive activity.

The transient receptor potential melastatin 2:a new therapeutical target for Parkinson's disease?

The transient receptor potential melastatin 2 is a calcium-permeable cation channel member of the TRP family. Also known as an oxidative stress-activated channel, the transient receptor potential melastatin 2 gating mechanism is dependent on reactive oxygen species. In pathological conditions, transient receptor potential melastatin 2 is overactivated, leading to a Ca~(2+) influx that alters cell homeostasis and promotes cell death. The role of transient receptor potential melastatin 2 in neurodegenerative diseases, including Alzheimer's disease and ischemia, has already been described and reviewed. However, data on transient receptor potential melastatin 2 involvement in Parkinson's disease pathology has emerged only in recent years and the issue lacks review studies that focus specifically on this topic. The present review aims to elucidate the role of the transient receptor potential melastatin 2 channel in Parkinson's disease by reviewing, summarizing, and discussing the in vitro, in vivo, and human studies published until August 2022. Here we describe fourteen studies that evaluated the transient receptor potential melastatin 2 channel in Parkinson's disease. The Parkinson's disease model used, transient receptor potential melastatin 2 antagonist and genetic approaches, and the main outcomes reported were discussed. The studies described transient receptor potential melastatin 2 activation and enhanced expression in different Parkinson's disease models. They also evidenced protective and restorative effects when using transient receptor potential melastatin 2 antagonists, knockout, or silencing. This review provides a literature overview and suggests where there is a need for more research. As a perspective point, this review shows evidence that supports transient receptor potential melastatin 2 as a pharmacological target for Parkinson's disease in the future.

藏药薰倒牛的活性物质研究

从植物藏药薰倒牛（ＢｉｅｂｅｒｓｔｅｉｎｉａｈｅｔｅｒｏｓｔｅｍｏｎＭａｘｉｍ．）中首次分离得７个化合物，经化学方法和光谱解析鉴定为：β－谷甾醇（Ⅰ）、胡萝卜甙（Ⅱ）、伞形花内酯（Ⅲ）、５，７，３′－三羟基－８，４′，５′－三甲氧基黄酮（Ⅳ）、木犀草素－７－葡萄糖甙（Ⅴ）、槲皮素－７－葡萄糖甙（Ⅵ）和Ｎ－３－甲基－２－丁烯基脲（Ⅶ）。其中Ⅳ和Ⅶ是二个新的天然产物。药理实验表明化合物Ⅶ有镇痛、降压等活性。