By the treatment of N-3-bromo-3-alkenylthioamides with sodium hydroxide in DMF-H2O in the presence of tetra-butylammonium bromide,series of 6-alkylidene-5,6-dihydro-4H-1,3-thiazine derivatives were prepared in moderat...By the treatment of N-3-bromo-3-alkenylthioamides with sodium hydroxide in DMF-H2O in the presence of tetra-butylammonium bromide,series of 6-alkylidene-5,6-dihydro-4H-1,3-thiazine derivatives were prepared in moderate to good yields.The cyclization is supposed to proceed via both the intramolecular vinylic nucleophilic substitution and the elimination-addition mechanisms(formation of acetylenic intermediates)in a competitive manner.展开更多
The novel title compound（Z）-N-（4-bromo-5-ethoxy-3,5-dimethylfuran-2（5H）-yli-dene）-4-methylbenzenesulfonamide 1（C15H18BrNO4S） has been unexpectedly synthesized by the aminohalogenation reaction of ethyl 2-methy...The novel title compound（Z）-N-（4-bromo-5-ethoxy-3,5-dimethylfuran-2（5H）-yli-dene）-4-methylbenzenesulfonamide 1（C15H18BrNO4S） has been unexpectedly synthesized by the aminohalogenation reaction of ethyl 2-methylpenta-2,3-dienoate with TsNBr2,and characterized by mp,IR,1H NMR,EIMS,ESIHRMS and single-crystal X-ray diffraction.It crystallizes in mono-clinic,space group P21/c with a = 11.714（5）,b = 14.106（5）,c = 10.402（4） ,β = 97.298（8）°,V = 1704.9（12） 3,Mr = 388.27,Z = 4,Dc = 1.513 g/cm3,μ（MoKα） = 2.549 mm-1,F（000） = 792,the final R = 0.033 and wR = 0.062 for 3098 observed reflections（Ⅰ 〉 2σ（Ⅰ））.展开更多
文摘By the treatment of N-3-bromo-3-alkenylthioamides with sodium hydroxide in DMF-H2O in the presence of tetra-butylammonium bromide,series of 6-alkylidene-5,6-dihydro-4H-1,3-thiazine derivatives were prepared in moderate to good yields.The cyclization is supposed to proceed via both the intramolecular vinylic nucleophilic substitution and the elimination-addition mechanisms(formation of acetylenic intermediates)in a competitive manner.
文摘The novel title compound（Z）-N-（4-bromo-5-ethoxy-3,5-dimethylfuran-2（5H）-yli-dene）-4-methylbenzenesulfonamide 1（C15H18BrNO4S） has been unexpectedly synthesized by the aminohalogenation reaction of ethyl 2-methylpenta-2,3-dienoate with TsNBr2,and characterized by mp,IR,1H NMR,EIMS,ESIHRMS and single-crystal X-ray diffraction.It crystallizes in mono-clinic,space group P21/c with a = 11.714（5）,b = 14.106（5）,c = 10.402（4） ,β = 97.298（8）°,V = 1704.9（12） 3,Mr = 388.27,Z = 4,Dc = 1.513 g/cm3,μ（MoKα） = 2.549 mm-1,F（000） = 792,the final R = 0.033 and wR = 0.062 for 3098 observed reflections（Ⅰ 〉 2σ（Ⅰ））.
