为提供一种电子电器产品中橡胶制品的TVOC监控手段,采用气相色谱-质谱法建立了测定橡胶制品中二丁基胺含量的检测方法。以甲醇作为液液萃取的提取剂,进行超声波提取,采用Aglient HP ULTRA 2色谱柱进行分离,质谱分析采用电子轰击离子源(E...为提供一种电子电器产品中橡胶制品的TVOC监控手段,采用气相色谱-质谱法建立了测定橡胶制品中二丁基胺含量的检测方法。以甲醇作为液液萃取的提取剂,进行超声波提取,采用Aglient HP ULTRA 2色谱柱进行分离,质谱分析采用电子轰击离子源(EI),选择离子监测(SIM)模式。数据显示,二丁基胺在甲醇中的含量与其特征离子峰面积呈线性关系。空白样品中的平均回收率为95.3%~100.2%,相对标准偏差(RSD,n=7)为0.8%~2.6%,测定低限为0.085 mg/kg。测试洗衣机观察窗样品中二丁基胺含量,测试结果显示含量较高,在室内使用存在空气污染的风险隐患,高温下烘烤更为严重,长期以往影响人体健康。展开更多
In this paper, it is evidenced by the quantitative structu re-carcinogenic activity relation-ship (QSCAR) and the pattern recognition treatment of N-nitroso compounds (NNC) that thekey step of carcinogenesis induced b...In this paper, it is evidenced by the quantitative structu re-carcinogenic activity relation-ship (QSCAR) and the pattern recognition treatment of N-nitroso compounds (NNC) that thekey step of carcinogenesis induced by NNC is the cross-linking on the complementary basepair of DNA, through the bifunctional alkylation between α-carbon and another carbonwithin the same chain. The alkylation by the α-carbon atom is through the diazonium salt,but that by the atom other than the α-position is through the active ester formed from thehydroxylated metabolite of the chain. Therefore, the alkylation by the β-position of NNC,or by its γ-position under suitable conditions, of which the distances from the α-positionboth approach 2. 80-3. 00 A, would be the most favourable positions along with the α-posi-tion for the cross-linking to occur between the complementary base pairs of DNA, whichwill yield the carcinogenic activity of NNC. The above conception of bifunctional alkyla-tion can reduce the QSCAR of NNC展开更多
文摘为提供一种电子电器产品中橡胶制品的TVOC监控手段,采用气相色谱-质谱法建立了测定橡胶制品中二丁基胺含量的检测方法。以甲醇作为液液萃取的提取剂,进行超声波提取,采用Aglient HP ULTRA 2色谱柱进行分离,质谱分析采用电子轰击离子源(EI),选择离子监测(SIM)模式。数据显示,二丁基胺在甲醇中的含量与其特征离子峰面积呈线性关系。空白样品中的平均回收率为95.3%~100.2%,相对标准偏差(RSD,n=7)为0.8%~2.6%,测定低限为0.085 mg/kg。测试洗衣机观察窗样品中二丁基胺含量,测试结果显示含量较高,在室内使用存在空气污染的风险隐患,高温下烘烤更为严重,长期以往影响人体健康。
基金Project supported the National Natural Science Foundation of China.
文摘In this paper, it is evidenced by the quantitative structu re-carcinogenic activity relation-ship (QSCAR) and the pattern recognition treatment of N-nitroso compounds (NNC) that thekey step of carcinogenesis induced by NNC is the cross-linking on the complementary basepair of DNA, through the bifunctional alkylation between α-carbon and another carbonwithin the same chain. The alkylation by the α-carbon atom is through the diazonium salt,but that by the atom other than the α-position is through the active ester formed from thehydroxylated metabolite of the chain. Therefore, the alkylation by the β-position of NNC,or by its γ-position under suitable conditions, of which the distances from the α-positionboth approach 2. 80-3. 00 A, would be the most favourable positions along with the α-posi-tion for the cross-linking to occur between the complementary base pairs of DNA, whichwill yield the carcinogenic activity of NNC. The above conception of bifunctional alkyla-tion can reduce the QSCAR of NNC
