Ethyl α-（dimethylaminomethylene）-2-cyanomethyl-4-phenylquinoline-3-carboxylate（2） as new synthons directed to 1-oxo-1,2-dihydrobenzo[b][1,6]naphthyridine-4-carbonitriles was obtained by the condensation of ethyl ...Ethyl α-（dimethylaminomethylene）-2-cyanomethyl-4-phenylquinoline-3-carboxylate（2） as new synthons directed to 1-oxo-1,2-dihydrobenzo[b][1,6]naphthyridine-4-carbonitriles was obtained by the condensation of ethyl 2-cyanomethyl-4-phenylquinoline-3-carboxylate（1） and N,N-dimethylformamide dimethyl acetal（DMFDMA）.Reaction of this enamine with primary amines（3） in HOAc-DMF at120 ℃then affords 2-substituted 1-oxo-1,2-dihydrobenzo[b][1,6]naphthyridine-4-carbonitrile derivatives（4） in good yields by a tandem addition-elimination-cyclization reaction.展开更多
基金financial support from the Science and Technology Department of Liaoning Province(No.2011220022)
文摘Ethyl α-（dimethylaminomethylene）-2-cyanomethyl-4-phenylquinoline-3-carboxylate（2） as new synthons directed to 1-oxo-1,2-dihydrobenzo[b][1,6]naphthyridine-4-carbonitriles was obtained by the condensation of ethyl 2-cyanomethyl-4-phenylquinoline-3-carboxylate（1） and N,N-dimethylformamide dimethyl acetal（DMFDMA）.Reaction of this enamine with primary amines（3） in HOAc-DMF at120 ℃then affords 2-substituted 1-oxo-1,2-dihydrobenzo[b][1,6]naphthyridine-4-carbonitrile derivatives（4） in good yields by a tandem addition-elimination-cyclization reaction.
