Aging is a complex issue due to its nature in progressive physiological and functional decay. As better medicine, technology, and living conditions became accessible to many people, the longevity of human beings incre...Aging is a complex issue due to its nature in progressive physiological and functional decay. As better medicine, technology, and living conditions became accessible to many people, the longevity of human beings increased during the past centuries. Recent research established vital roles for NAD＋ and its precursors in protecting and maintaining the redox homeostasis in cells, which might be applicable therapeutically to prevent cell degeneration. Notably, the contribution of NAD＋ metabolites to lifespan extension in model systems indicates that the potential beneficial effects of NAD＋ precursors. In this mini review, by introducing the background of NAD＋-consuming enzymes in ＂caloric restriction＂, we focus on NAD＋ and its precursors in diet, with further emphasis on its association with health and diseases. We also provide insights in future utilization ofNAD＋ and its precursors as nutrition supplement for lifespan extension.展开更多
基金We gratefully acknowledge the National Natural Science Foundation of China （No. 21502026）, Shenzhen Science and Technology Innovation Committee （JCYJ20140411112047887） for their support to Yanchao Pan. We thank Dr. Zhen Xie for comments on the manuscript.
文摘Aging is a complex issue due to its nature in progressive physiological and functional decay. As better medicine, technology, and living conditions became accessible to many people, the longevity of human beings increased during the past centuries. Recent research established vital roles for NAD＋ and its precursors in protecting and maintaining the redox homeostasis in cells, which might be applicable therapeutically to prevent cell degeneration. Notably, the contribution of NAD＋ metabolites to lifespan extension in model systems indicates that the potential beneficial effects of NAD＋ precursors. In this mini review, by introducing the background of NAD＋-consuming enzymes in ＂caloric restriction＂, we focus on NAD＋ and its precursors in diet, with further emphasis on its association with health and diseases. We also provide insights in future utilization ofNAD＋ and its precursors as nutrition supplement for lifespan extension.
