Negatively thermo-responsive 2D membranes,which mimic the stomatal opening/closing of plants,have drawn substantial interest for tunable molecular separation processes.However,these membranes are still restricted sign...Negatively thermo-responsive 2D membranes,which mimic the stomatal opening/closing of plants,have drawn substantial interest for tunable molecular separation processes.However,these membranes are still restricted significantly on account of low water permeability and poor dynamic tunability of 2D nanochannels under temperature stimulation.Here,we present a biomimetic negatively thermo-responsive MXene membrane by covalently grafting poly(N-isopropylacrylamide)(PNIPAm)onto MXene nanosheets.The uniformly grafted PNIPAm polymer chains can enlarge the interlayer spacings for increasing water permeability while also allowing more tunability of 2D nanochannels for enhancing the capability of gradually separating multiple molecules of different sizes.As expected,the constructed membrane exhibits ultrahigh water permeance of 95.6 L m^(-2) h^(-1) bar^(-1) at 25℃,which is eight-fold higher than the state-of-the-art negatively thermoresponsive 2D membranes.Moreover,the highly temperature-tunable 2D nanochannels enable the constructed membrane to perform excellent graded molecular sieving for dye-and antibiotic-based ternary mixtures.This strategy provides new perspectives in engineering smart 2D membrane and expands the scope of temperature-responsive membranes,showing promising applications in micro/nanofluidics and molecular separation.展开更多
The atomic behavior of liquid-solid mixed-phase nanofluid flows inside nanochannels is investigated by a molecular dynamics simulation (MDS). The results of visual observation and statistic analysis show that when t...The atomic behavior of liquid-solid mixed-phase nanofluid flows inside nanochannels is investigated by a molecular dynamics simulation (MDS). The results of visual observation and statistic analysis show that when the nanoparticles reach near each other, the strong interatomic force will make them attach together. This aggrega- tion continues until all nanoparticles make a continuous cluster. The effect of altering the external force magnitude causes changes in the agglomeration rate and system enthalpy. The density and velocity profiles are shown for two systems, i.e., argon (Ar)-copper (Cu) nanofluid and simple Ar fluid between two Cu walls. The results show that using nanopar- ticles changes the base fluid particles ordering along the nanochannel and increases the velocity. Moreover, using nanoparticles in simple fluids can increase the slip length and push the near-wall fluid particles into the main flow in the middle of the nanochannel.展开更多
U-shaped micro-nanochannels can generate significant flow disturbance as well as locally amplified electric field, which gives itself potential to be microfluidic mixers, electrokinetic pumps,and even cell lysis proce...U-shaped micro-nanochannels can generate significant flow disturbance as well as locally amplified electric field, which gives itself potential to be microfluidic mixers, electrokinetic pumps,and even cell lysis process. Numerical simulation is utilized in this work to study the hidden characteristics of the U-shaped micro-nanochannel system, and the effects of key controlling parameters(the external voltage and pressure) on the device output metrics(current, maximum values of electric field, shear stress and flow velocity) were evaluated. A large portion of current flowing through the whole system goes through the nanochannels, rather than the middle part of the microchannel, with its value increasing linearly with the increase of voltage. Due to the local ion depletion near micro-nanofluidic junction, significantly enhanced electric field(as much as 15 fold at V=1 V and P_0=0) as well as strong shear stress(leading to electrokinetic flow) is generated.With increasing external pressure, both electric field and shear stress can be increased initially(due to shortening of depletion region length), but are suppressed eventually at higher pressure due to the destruction of ion depletion layer. Insights gained from this study could be useful for designing nonlinear electrokinetic pumps and other systems.展开更多
A novel mixed barium(II)/silver(I)/chromium(III) oxalate salt, Ba<sub>0.5</sub>Ag<sub>2</sub>[Cr(C<sub>2</sub>O<sub>4</sub>)<sub>3</sub>]·5H<sub>2...A novel mixed barium(II)/silver(I)/chromium(III) oxalate salt, Ba<sub>0.5</sub>Ag<sub>2</sub>[Cr(C<sub>2</sub>O<sub>4</sub>)<sub>3</sub>]·5H<sub>2</sub>O (1), with open architecture has been synthesized in water and characterized by elemental analysis, vibrational and electronic spectra, and single crystal X-ray structure determination. Compound 1 crystallizes in a monoclinic space group C2/c, with unit cell parameters a = 18.179(3), b = 14.743(2), c = 12.278(2)Å, β = 113.821(3), V = 3010.34(90) Å<sup>3</sup>, Z = 8. The structure is characterized by a network of anionic [Cr(C<sub>2</sub>O<sub>4</sub>)<sub>3</sub>]<sup>3-</sup> units connected through the O atoms of the oxalates to Ba<sup>2+</sup> and Ag<sup>+</sup> sites, forming a three-dimensional coordination polymer with one-dimensional isolated nanochannels parallel to the c axis, and encapsulating hydrogen-bonded guest water molecules. The bulk structure is consolidated by O–H···O bridgings within the nanochannels and by coulombic interactions.展开更多
Nonmechanical pumping of liquids is of key importance for applications from the biomedical microfluidic chip to drug delivery systems. In this paper, a new electrokinetic pump (EOP) system with polycarbonate nanoeha...Nonmechanical pumping of liquids is of key importance for applications from the biomedical microfluidic chip to drug delivery systems. In this paper, a new electrokinetic pump (EOP) system with polycarbonate nanoehannel membrane sandwiched between two membrane holders was constructed. The pump was tested with water and phosphate buffer at 1-6 V applied voltage, the maximum pressure and flow rate are 0.32 MPa (3.2 atm) and 4.2 μL/min for phosphate buffer, respectively. This proof-of-concept pump shows its potential use for drugs or chemical agents delivery by the usage of different membrane materials.展开更多
We consider an incompressible fluid in a rectangular nanochannel. We solve numerically the three dimensional Fourier heat equation to get the steady solution for the temperature. Then we set and solve the Langevin equ...We consider an incompressible fluid in a rectangular nanochannel. We solve numerically the three dimensional Fourier heat equation to get the steady solution for the temperature. Then we set and solve the Langevin equation for the temperature. We have developed equations in order to determine relaxation time of the temperature fluctuations, τT = 4.62 × 10-10s. We have performed a spectral analysis of the thermal fluctuations, with the result that temporal correlations are in the one-digit ps range, and the thermal noise excites the thermal modes in the two-digit GHz range. Also we observe long-range spatial correlation up to more than half the size of the cell, 600 nm;the wave number, q, is in the 106 m-1 range. We have also determined two thermal relaxation lengths in the z direction: l1 = 1.18 nm and l2 = 9.86 nm.展开更多
Reaction of Ba0.50[Ag2Cr(C2O4)3]·5H2O with Ag2SO4 in an aqueous solution of sulfuric acid (pH ≈ 3) yielded the silver(I)/chromium(III) oxalate salt H0.50[Ag2.50Cr(C2O4)3]·5H2O (1). Compound 1 can be best de...Reaction of Ba0.50[Ag2Cr(C2O4)3]·5H2O with Ag2SO4 in an aqueous solution of sulfuric acid (pH ≈ 3) yielded the silver(I)/chromium(III) oxalate salt H0.50[Ag2.50Cr(C2O4)3]·5H2O (1). Compound 1 can be best described as an anionic silver-deficient oxalatochromate(III) complex [Ag2.50Cr(C2O4)3]0.5- with nanochannels containing hydrogen-bonded water molecules and protons. Thermal analyses show significant weight losses corresponding to the elimination of water molecules of crystallization followed by the decomposition of the network.展开更多
Nanochannels have made great progress and are a promising platform for detecting a series of targets.However,most nanochannels are modified on the inner wall,while ignoring the outer surface.Here,we modified the outer...Nanochannels have made great progress and are a promising platform for detecting a series of targets.However,most nanochannels are modified on the inner wall,while ignoring the outer surface.Here,we modified the outer surface of nanochannels with hydrogel.Different from other reported outer-surface modification methods,we directly cover nanochannels with hydrogel to form heterogeneous membrane.The selected hydrogel hardly adsorbs other ions and shows specific adsorption for Cr(VI).The adsorption sites in hydrogel are homogeneous,and Cr(VI)adsorption onto hydrogel is endothermic and spontaneous.The charge in hydrogel changes after Cr(VI)adsorption,and the resulting current changes can be used for the detection of Cr(VI)with the detection limit of 10−11 mol/L.Our platform is expected to be used for Cr(VI)detection in living organisms,especially within cells.This work provides a new approach for outer-surface modification of nanochannels and offers a new choice for nanochannel detection platforms.展开更多
Cancers and chronic diseases have always been global health problems. The occurrence and development of such diseases are closely related to the abnormalities of proteins, nucleic acids, ions or small molecules in the...Cancers and chronic diseases have always been global health problems. The occurrence and development of such diseases are closely related to the abnormalities of proteins, nucleic acids, ions or small molecules in the body. Nowadays, nanopores/nanochannels have emerged as a powerful platform for detecting these biomolecules based on the electrical signal variation caused by biomolecules passing. However, detection relied on the electrical signal easily suffered from the clogging defects, low throughput, and strong background signals. Fortunately, the emergence of designing nanopores/nanochannels based on electrical and optical dual signal response has brought innovative impetus to biological detection, which can also identify the chemical compositions and conformations of the biomolecules. In this review, we summarize the reasonable preparation of nanopores/nanochannels with electrical and optical dual signal response and their application in biological detection. According to different biomolecules, we divide the targets into four types, including nucleic acids, small molecules, ions and proteins. In each section, the design of representative examples and the principle of dual signal generation are introduced and discussed. Finally, the prospects and challenges of nanopores/nanochannels based on electrical and optical dual signal response are also discussed.展开更多
Two-dimensional(2D)material-based membrane separation has attracted increasing attention due to its promising performance compared with traditional membranes.However,in-depth understanding of water transportation beha...Two-dimensional(2D)material-based membrane separation has attracted increasing attention due to its promising performance compared with traditional membranes.However,in-depth understanding of water transportation behavior in such confined nanochannels is still lacking,which hinders the development of 2D nanosheets membranes.Herein,we investigated water confined in graphene or MoS_(2)nanochannels by molecular dynamics(MD)simulations and found water’s diffusivity always varied linearly with their mean square displacement along z direction(Δz^(2))when system variables(e.g.,water molecules’number,channel height,nonbonded interaction parameter,harmonic potential constraining water’s z-coordinate)changed.Such linear correlation applies to different water models and different force fields(FFs)of channel walls(e.g.,different Lennard–Jones parameters or even flexible FF),no matter whether water molecules form 3-,2-,or quasi-2-layer structure in the nanochannel.This indicates,though water molecules’motion along z direction(z-fluctuation,confined within 1 nm)and that in xy plane(xydiffusion)are entirely different,they are tightly coupled:Violent z-fluctuation would produce more transient void to facilitate xydiffusion,which is to the sharp contrary of bulk water,where motions in x,y,z directions are symmetric,but independent.Our work could help design high performance 2D nanochannels and discover more novel principles in nano-fluidics and membrane separation fields.展开更多
With the development of nanotechnology and materials science,bioinspired nanochannels appeared by mimicking the intelligent functions of biological ion channels.They have attracted a great deal of at-tention in recent...With the development of nanotechnology and materials science,bioinspired nanochannels appeared by mimicking the intelligent functions of biological ion channels.They have attracted a great deal of at-tention in recent years due to their controllable structure and tunable chemical properties.Inspired by the layered microstructure of nacre,2D layered materials as excellent matrix material of nanochannel come into our field of vision.Bionic nanochannels based on 2D materials have the advantages of facile preparation,tunable channel size and length,easy expansion,and modification,etc.Therefore,the 2D layered nanofluid system based on bionic nanochannels from 2D layered materials has great potential in biomimetic microsensors,membrane separations,energy conversion,and so on.In this paper,we focus on the construction and application of bionic nanochannels based on 2D layer materials.First,a basic understanding of nanochannels based on 2D materials is briefly introduced,we also present the property of the 2D materials and construction strategies of bionic nanochannels.Subsequently,the application of these nanochannels in responsive channels and energy conversion is discussed.The unsolved challenges and prospects of 2D materials-based nanochannels are proposed in the end.展开更多
A molecular dynamics (MD) model of the fluidic electrokinetic transport in a nano-scale channel with two bulk sinks was presented, and the process of ion transport in the nanochannel was simulated in this paper. The m...A molecular dynamics (MD) model of the fluidic electrokinetic transport in a nano-scale channel with two bulk sinks was presented, and the process of ion transport in the nanochannel was simulated in this paper. The model consists of two water sinks at the two ends and a pump in the middle, which is different from a single pump model in previous MD simulations. Simulation results show that the charged surfaces of the nanochannel result in the depletion of co-ions and the enrichment of counterions in the nanochannel. A stable current is induced because of the motion of ions when an external electric field is applied across the nanochannel, and the current in the pump region is mainly induced by the motion of counterions. In addition, the ion number in the pump region rapidly decreases as the external electric field is applied. In the equilibrated system, the electrically neutral character in the pump region is destroyed and this region displays a certain electrical character, which depends on the surface charge. The ion distribution is greatly different from the results predicted by the continuum theory, e.g. a smaller peak value of Na+ concentration appears near the wall. The transport efficiency of counterions (co-ions) can be effectively increased (decreased) by increasing the surface charge density. The simulation results demonstrate that the ion distribution in the electric double layer (EDL) of a nanochannel cannot be exactly described by the classical Gouy-Chapman-Stern (GCS) theory model. The mechanism of some special experimental phenomena in a nanochannel and the effect of the surface charge density on the ion-transport efficiency were also explored to provide some theoretical insights for the design and application of nano-scale fluidic pumps.展开更多
Biomimetic nanodevice is an important branch to expand the potential applications of artificial nanochannels. Here, we constructed nanochannels for cascade response of borate and cis-hydroxyl compounds by modifying th...Biomimetic nanodevice is an important branch to expand the potential applications of artificial nanochannels. Here, we constructed nanochannels for cascade response of borate and cis-hydroxyl compounds by modifying the nanochannels of track-etched polycarbonate (TEPC) membranes with polyvinyl alcohol (PVA). Firstly, borate bound to PVA and increased the negative charge density on the surface of the nanochannels, which obstructed the transport of 1,5-naphthalene disulfonate (NDS2-). Subsequently, the addition of cis-hydroxyl compounds induced leaving of borate due to the stronger binding affinities between borate and cis-hydroxyl compounds, which reduced the negative charge density on nanochannels and then enhanced the transport of NDS2-. The cascade response of the nanochannels also accord with the properties of IMP (implication) logic gate. In addition, such nanochannels showed good reproducibility and reversibility. Therefore, this cascade response model based on nanochannels has the potential to be used as switches in area of actuators and biosensors, and is also expected to be used to understand the interaction of substances in nanoscale and simulate the physiological functions of boron.展开更多
Imitating the signal transduction and transmembrane transport co ntrolled by biological channels in the cell membra ne,artificial nanochannels with a similar capability of sensing and transport are constructed as bion...Imitating the signal transduction and transmembrane transport co ntrolled by biological channels in the cell membra ne,artificial nanochannels with a similar capability of sensing and transport are constructed as bionic nanochannels.To accomplish selective sensing and transport of biological analyte(as "guest"),the bionic nanochannels are modified with the artificial receptor(as "host"),Based on selective recognition between host and guest,bionic nanochannels translate the stimulus of the guest to electrochemical signal as sensors,and further regulate the transmission of guest as transporters.Howeve r,throughout all kinds of guests,the selective sensing and transpo rt of ions and chiral molecules is a challenging problem.And throughout all hosts of ions and chiral molecules,the macrocyclic hosts with multisite of recognition show better selectivity,such as crown ethers,cyclodextrins,calixarenes,and pillararenes.In this article,we highlight recent advances in the macrocyclic host-based nanochannels for the selective sensing and transport of ionic and chiral guests,summarize the similarities and differences of different kinds of macrocyclic host-based nanochannels,and expect the research direction and application prospect.展开更多
With the increasing requirements of reliable and environmentally friendly energy resources, porous materials for sustainable energy conversion technologies have attracted intensive interest in the past decades. As an ...With the increasing requirements of reliable and environmentally friendly energy resources, porous materials for sustainable energy conversion technologies have attracted intensive interest in the past decades. As an important block of porous materials, biomimetic smart nanochannels (BSN) have been developed rapidly into an attractive field for their well-tunable geometry and chemistry. With inspiration from nature, many works have been reported to utilize BSN to harvest clean energy. In this review, we summarize recent progress in the BSN for power harvesting from four parts of brief introduction of BSN, biological prototypes for power harvesting, BSN-based energy conversion, and conclusion and outlook. Overall, by learning from nature, exploiting new avenues and improving the performance of BSN, a number of exciting developments in the near future may be anticipated.展开更多
Confinement can induce unusual behaviors of water. Inspired by the fabrication of carbon nanotubes with noncircular cross sections, we performed molecular dynamics simulations to investigate the mobilities of water co...Confinement can induce unusual behaviors of water. Inspired by the fabrication of carbon nanotubes with noncircular cross sections, we performed molecular dynamics simulations to investigate the mobilities of water confined in carbon nanochannels with circular, square, and equilateral triangular cross sections over a variety of dimensions. We find that water exhibits disparate mobilities across different types of channels below 0.796 nm(2). Notably, compared with the other two channels, water in equilateral triangular channels displays the greatest mobilities. Moreover, at 0.425 nm(2), different ordered structures are found in the three channels, and water inside the square channel exhibits an extremely low mobility. It is also found that above 0.796 nm(2), the mobilities along the tube axis of water converge to that of the bulk. These phenomena are understood by analyzing the structure, dynamics, and hydrogen bonding of water. Our work explores the mobilities of water across noncircular carbon nanochannels, which may expand the prospect of noncircular nanochannels in scientific studies and practical applications, such as desalination and drug delivery.展开更多
基金supported by the National Nature Science Foundation of China(No.22278179,U23A20688)the National Key Research and Development Program of China(2021YFB3802600)+3 种基金the Fundamental Research Funds for the Central Universities(JUSRP622035)National First-Class Discipline Program of Light Industry Technology and Engineering(LIFE2018-19)MOE&SAFEA for the 111 Project(B13025)Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01D030).
文摘Negatively thermo-responsive 2D membranes,which mimic the stomatal opening/closing of plants,have drawn substantial interest for tunable molecular separation processes.However,these membranes are still restricted significantly on account of low water permeability and poor dynamic tunability of 2D nanochannels under temperature stimulation.Here,we present a biomimetic negatively thermo-responsive MXene membrane by covalently grafting poly(N-isopropylacrylamide)(PNIPAm)onto MXene nanosheets.The uniformly grafted PNIPAm polymer chains can enlarge the interlayer spacings for increasing water permeability while also allowing more tunability of 2D nanochannels for enhancing the capability of gradually separating multiple molecules of different sizes.As expected,the constructed membrane exhibits ultrahigh water permeance of 95.6 L m^(-2) h^(-1) bar^(-1) at 25℃,which is eight-fold higher than the state-of-the-art negatively thermoresponsive 2D membranes.Moreover,the highly temperature-tunable 2D nanochannels enable the constructed membrane to perform excellent graded molecular sieving for dye-and antibiotic-based ternary mixtures.This strategy provides new perspectives in engineering smart 2D membrane and expands the scope of temperature-responsive membranes,showing promising applications in micro/nanofluidics and molecular separation.
文摘The atomic behavior of liquid-solid mixed-phase nanofluid flows inside nanochannels is investigated by a molecular dynamics simulation (MDS). The results of visual observation and statistic analysis show that when the nanoparticles reach near each other, the strong interatomic force will make them attach together. This aggrega- tion continues until all nanoparticles make a continuous cluster. The effect of altering the external force magnitude causes changes in the agglomeration rate and system enthalpy. The density and velocity profiles are shown for two systems, i.e., argon (Ar)-copper (Cu) nanofluid and simple Ar fluid between two Cu walls. The results show that using nanopar- ticles changes the base fluid particles ordering along the nanochannel and increases the velocity. Moreover, using nanoparticles in simple fluids can increase the slip length and push the near-wall fluid particles into the main flow in the middle of the nanochannel.
基金supported by the Intergovernmental International Science,Technology and Innovation Cooperation Key Project of the National Key R&D Programme(2016YFE0105900)the National Natural Science Foundation of China(21576130and 11372229)Kuwait Foundation for the Advancement of Sciences(Kuwait-MIT signature project,Project code:P31475EC01)
文摘U-shaped micro-nanochannels can generate significant flow disturbance as well as locally amplified electric field, which gives itself potential to be microfluidic mixers, electrokinetic pumps,and even cell lysis process. Numerical simulation is utilized in this work to study the hidden characteristics of the U-shaped micro-nanochannel system, and the effects of key controlling parameters(the external voltage and pressure) on the device output metrics(current, maximum values of electric field, shear stress and flow velocity) were evaluated. A large portion of current flowing through the whole system goes through the nanochannels, rather than the middle part of the microchannel, with its value increasing linearly with the increase of voltage. Due to the local ion depletion near micro-nanofluidic junction, significantly enhanced electric field(as much as 15 fold at V=1 V and P_0=0) as well as strong shear stress(leading to electrokinetic flow) is generated.With increasing external pressure, both electric field and shear stress can be increased initially(due to shortening of depletion region length), but are suppressed eventually at higher pressure due to the destruction of ion depletion layer. Insights gained from this study could be useful for designing nonlinear electrokinetic pumps and other systems.
文摘A novel mixed barium(II)/silver(I)/chromium(III) oxalate salt, Ba<sub>0.5</sub>Ag<sub>2</sub>[Cr(C<sub>2</sub>O<sub>4</sub>)<sub>3</sub>]·5H<sub>2</sub>O (1), with open architecture has been synthesized in water and characterized by elemental analysis, vibrational and electronic spectra, and single crystal X-ray structure determination. Compound 1 crystallizes in a monoclinic space group C2/c, with unit cell parameters a = 18.179(3), b = 14.743(2), c = 12.278(2)Å, β = 113.821(3), V = 3010.34(90) Å<sup>3</sup>, Z = 8. The structure is characterized by a network of anionic [Cr(C<sub>2</sub>O<sub>4</sub>)<sub>3</sub>]<sup>3-</sup> units connected through the O atoms of the oxalates to Ba<sup>2+</sup> and Ag<sup>+</sup> sites, forming a three-dimensional coordination polymer with one-dimensional isolated nanochannels parallel to the c axis, and encapsulating hydrogen-bonded guest water molecules. The bulk structure is consolidated by O–H···O bridgings within the nanochannels and by coulombic interactions.
文摘Nonmechanical pumping of liquids is of key importance for applications from the biomedical microfluidic chip to drug delivery systems. In this paper, a new electrokinetic pump (EOP) system with polycarbonate nanoehannel membrane sandwiched between two membrane holders was constructed. The pump was tested with water and phosphate buffer at 1-6 V applied voltage, the maximum pressure and flow rate are 0.32 MPa (3.2 atm) and 4.2 μL/min for phosphate buffer, respectively. This proof-of-concept pump shows its potential use for drugs or chemical agents delivery by the usage of different membrane materials.
文摘We consider an incompressible fluid in a rectangular nanochannel. We solve numerically the three dimensional Fourier heat equation to get the steady solution for the temperature. Then we set and solve the Langevin equation for the temperature. We have developed equations in order to determine relaxation time of the temperature fluctuations, τT = 4.62 × 10-10s. We have performed a spectral analysis of the thermal fluctuations, with the result that temporal correlations are in the one-digit ps range, and the thermal noise excites the thermal modes in the two-digit GHz range. Also we observe long-range spatial correlation up to more than half the size of the cell, 600 nm;the wave number, q, is in the 106 m-1 range. We have also determined two thermal relaxation lengths in the z direction: l1 = 1.18 nm and l2 = 9.86 nm.
文摘Reaction of Ba0.50[Ag2Cr(C2O4)3]·5H2O with Ag2SO4 in an aqueous solution of sulfuric acid (pH ≈ 3) yielded the silver(I)/chromium(III) oxalate salt H0.50[Ag2.50Cr(C2O4)3]·5H2O (1). Compound 1 can be best described as an anionic silver-deficient oxalatochromate(III) complex [Ag2.50Cr(C2O4)3]0.5- with nanochannels containing hydrogen-bonded water molecules and protons. Thermal analyses show significant weight losses corresponding to the elimination of water molecules of crystallization followed by the decomposition of the network.
基金supported by the National Natural Science Foundation of China(No.22090050)the National Key R&D Program of China(No.2021YFA1200403)the Joint National Natural Science Foundation of China-Israel Science Foundation(NSFC-ISF)Research Grant Program(No.22161142020).
文摘Nanochannels have made great progress and are a promising platform for detecting a series of targets.However,most nanochannels are modified on the inner wall,while ignoring the outer surface.Here,we modified the outer surface of nanochannels with hydrogel.Different from other reported outer-surface modification methods,we directly cover nanochannels with hydrogel to form heterogeneous membrane.The selected hydrogel hardly adsorbs other ions and shows specific adsorption for Cr(VI).The adsorption sites in hydrogel are homogeneous,and Cr(VI)adsorption onto hydrogel is endothermic and spontaneous.The charge in hydrogel changes after Cr(VI)adsorption,and the resulting current changes can be used for the detection of Cr(VI)with the detection limit of 10−11 mol/L.Our platform is expected to be used for Cr(VI)detection in living organisms,especially within cells.This work provides a new approach for outer-surface modification of nanochannels and offers a new choice for nanochannel detection platforms.
基金financial support by the National Key R&D Program of China(2021YFA1200403,2020YFA0211200)the National Natural Science Foundation of China(22090050,21974128,21874121,52003257,22104040)+2 种基金the Joint NSFC-ISF Research Grant Program(Grant No:22161142020)the Hubei Provincial Natural Science Foundation of China(2020CFA037)the Zhejiang Provincial Natural Science Foundation of China under Grant No.LD21B050001.
文摘Cancers and chronic diseases have always been global health problems. The occurrence and development of such diseases are closely related to the abnormalities of proteins, nucleic acids, ions or small molecules in the body. Nowadays, nanopores/nanochannels have emerged as a powerful platform for detecting these biomolecules based on the electrical signal variation caused by biomolecules passing. However, detection relied on the electrical signal easily suffered from the clogging defects, low throughput, and strong background signals. Fortunately, the emergence of designing nanopores/nanochannels based on electrical and optical dual signal response has brought innovative impetus to biological detection, which can also identify the chemical compositions and conformations of the biomolecules. In this review, we summarize the reasonable preparation of nanopores/nanochannels with electrical and optical dual signal response and their application in biological detection. According to different biomolecules, we divide the targets into four types, including nucleic acids, small molecules, ions and proteins. In each section, the design of representative examples and the principle of dual signal generation are introduced and discussed. Finally, the prospects and challenges of nanopores/nanochannels based on electrical and optical dual signal response are also discussed.
基金the National Natural Science Foundation of China(Nos.22078104,22022805,and 22078107)the National Key Research and Development Program(No.2021YFB3802500)+2 种基金the financial support from the Science and Technology Key Project of Guangdong Province(No.2020B010188002)State Key Laboratory of Pulp and Paper Engineering(No.2022PY04)Fundamental Research Funds for the Central Universities(No.2022ZYGXZR010).
文摘Two-dimensional(2D)material-based membrane separation has attracted increasing attention due to its promising performance compared with traditional membranes.However,in-depth understanding of water transportation behavior in such confined nanochannels is still lacking,which hinders the development of 2D nanosheets membranes.Herein,we investigated water confined in graphene or MoS_(2)nanochannels by molecular dynamics(MD)simulations and found water’s diffusivity always varied linearly with their mean square displacement along z direction(Δz^(2))when system variables(e.g.,water molecules’number,channel height,nonbonded interaction parameter,harmonic potential constraining water’s z-coordinate)changed.Such linear correlation applies to different water models and different force fields(FFs)of channel walls(e.g.,different Lennard–Jones parameters or even flexible FF),no matter whether water molecules form 3-,2-,or quasi-2-layer structure in the nanochannel.This indicates,though water molecules’motion along z direction(z-fluctuation,confined within 1 nm)and that in xy plane(xydiffusion)are entirely different,they are tightly coupled:Violent z-fluctuation would produce more transient void to facilitate xydiffusion,which is to the sharp contrary of bulk water,where motions in x,y,z directions are symmetric,but independent.Our work could help design high performance 2D nanochannels and discover more novel principles in nano-fluidics and membrane separation fields.
基金supported by the National Natural Science Foundation of China (No. 22005162)the Natural Science Foundation of Shandong Province (No. ZR2020QE093)+1 种基金the China Postdoctoral Science Foundation (No. 2019M652319)the Special Financial Aid to Post-doctor Research Fellow (No. 2020T130330)
文摘With the development of nanotechnology and materials science,bioinspired nanochannels appeared by mimicking the intelligent functions of biological ion channels.They have attracted a great deal of at-tention in recent years due to their controllable structure and tunable chemical properties.Inspired by the layered microstructure of nacre,2D layered materials as excellent matrix material of nanochannel come into our field of vision.Bionic nanochannels based on 2D materials have the advantages of facile preparation,tunable channel size and length,easy expansion,and modification,etc.Therefore,the 2D layered nanofluid system based on bionic nanochannels from 2D layered materials has great potential in biomimetic microsensors,membrane separations,energy conversion,and so on.In this paper,we focus on the construction and application of bionic nanochannels based on 2D layer materials.First,a basic understanding of nanochannels based on 2D materials is briefly introduced,we also present the property of the 2D materials and construction strategies of bionic nanochannels.Subsequently,the application of these nanochannels in responsive channels and energy conversion is discussed.The unsolved challenges and prospects of 2D materials-based nanochannels are proposed in the end.
基金the National Basic Research Program of China (Grant No. 2006CB300404)the National Natural Science Foundation of China (Grant Nos. 50475077, 50676019, 50506008)+1 种基金the Natural Science Foundation of Jiangsu Province (Grant No. BK2006510)the Foundation of Education Ministry of China (Grant No. 20050286019)
文摘A molecular dynamics (MD) model of the fluidic electrokinetic transport in a nano-scale channel with two bulk sinks was presented, and the process of ion transport in the nanochannel was simulated in this paper. The model consists of two water sinks at the two ends and a pump in the middle, which is different from a single pump model in previous MD simulations. Simulation results show that the charged surfaces of the nanochannel result in the depletion of co-ions and the enrichment of counterions in the nanochannel. A stable current is induced because of the motion of ions when an external electric field is applied across the nanochannel, and the current in the pump region is mainly induced by the motion of counterions. In addition, the ion number in the pump region rapidly decreases as the external electric field is applied. In the equilibrated system, the electrically neutral character in the pump region is destroyed and this region displays a certain electrical character, which depends on the surface charge. The ion distribution is greatly different from the results predicted by the continuum theory, e.g. a smaller peak value of Na+ concentration appears near the wall. The transport efficiency of counterions (co-ions) can be effectively increased (decreased) by increasing the surface charge density. The simulation results demonstrate that the ion distribution in the electric double layer (EDL) of a nanochannel cannot be exactly described by the classical Gouy-Chapman-Stern (GCS) theory model. The mechanism of some special experimental phenomena in a nanochannel and the effect of the surface charge density on the ion-transport efficiency were also explored to provide some theoretical insights for the design and application of nano-scale fluidic pumps.
基金the financial support from the National Natural Science Foundation of China(Nos. 21675047, 21735002 and 21521063)the Key Point Research and Invention Program of Hunan Province(No. 2017DK2011)
文摘Biomimetic nanodevice is an important branch to expand the potential applications of artificial nanochannels. Here, we constructed nanochannels for cascade response of borate and cis-hydroxyl compounds by modifying the nanochannels of track-etched polycarbonate (TEPC) membranes with polyvinyl alcohol (PVA). Firstly, borate bound to PVA and increased the negative charge density on the surface of the nanochannels, which obstructed the transport of 1,5-naphthalene disulfonate (NDS2-). Subsequently, the addition of cis-hydroxyl compounds induced leaving of borate due to the stronger binding affinities between borate and cis-hydroxyl compounds, which reduced the negative charge density on nanochannels and then enhanced the transport of NDS2-. The cascade response of the nanochannels also accord with the properties of IMP (implication) logic gate. In addition, such nanochannels showed good reproducibility and reversibility. Therefore, this cascade response model based on nanochannels has the potential to be used as switches in area of actuators and biosensors, and is also expected to be used to understand the interaction of substances in nanoscale and simulate the physiological functions of boron.
基金financially supported by the National Key Research and Development Program of China (No.2018YFD0200102)the National Natural Science Foundation of China (Nos.21911530178 and 21772055)+1 种基金the 111 Project (No.B17019)Self-determined research funds of CCNU from the colleges’ basic research and operation of MOE。
文摘Imitating the signal transduction and transmembrane transport co ntrolled by biological channels in the cell membra ne,artificial nanochannels with a similar capability of sensing and transport are constructed as bionic nanochannels.To accomplish selective sensing and transport of biological analyte(as "guest"),the bionic nanochannels are modified with the artificial receptor(as "host"),Based on selective recognition between host and guest,bionic nanochannels translate the stimulus of the guest to electrochemical signal as sensors,and further regulate the transmission of guest as transporters.Howeve r,throughout all kinds of guests,the selective sensing and transpo rt of ions and chiral molecules is a challenging problem.And throughout all hosts of ions and chiral molecules,the macrocyclic hosts with multisite of recognition show better selectivity,such as crown ethers,cyclodextrins,calixarenes,and pillararenes.In this article,we highlight recent advances in the macrocyclic host-based nanochannels for the selective sensing and transport of ionic and chiral guests,summarize the similarities and differences of different kinds of macrocyclic host-based nanochannels,and expect the research direction and application prospect.
基金This work was supported by the National Natural Science Foundation of China (Nos. 21171171, 21434003, and 91427303), and the Key Research Program of the Chinese Academy of Sciences (No. KJZD-EW-M03).
文摘With the increasing requirements of reliable and environmentally friendly energy resources, porous materials for sustainable energy conversion technologies have attracted intensive interest in the past decades. As an important block of porous materials, biomimetic smart nanochannels (BSN) have been developed rapidly into an attractive field for their well-tunable geometry and chemistry. With inspiration from nature, many works have been reported to utilize BSN to harvest clean energy. In this review, we summarize recent progress in the BSN for power harvesting from four parts of brief introduction of BSN, biological prototypes for power harvesting, BSN-based energy conversion, and conclusion and outlook. Overall, by learning from nature, exploiting new avenues and improving the performance of BSN, a number of exciting developments in the near future may be anticipated.
文摘Confinement can induce unusual behaviors of water. Inspired by the fabrication of carbon nanotubes with noncircular cross sections, we performed molecular dynamics simulations to investigate the mobilities of water confined in carbon nanochannels with circular, square, and equilateral triangular cross sections over a variety of dimensions. We find that water exhibits disparate mobilities across different types of channels below 0.796 nm(2). Notably, compared with the other two channels, water in equilateral triangular channels displays the greatest mobilities. Moreover, at 0.425 nm(2), different ordered structures are found in the three channels, and water inside the square channel exhibits an extremely low mobility. It is also found that above 0.796 nm(2), the mobilities along the tube axis of water converge to that of the bulk. These phenomena are understood by analyzing the structure, dynamics, and hydrogen bonding of water. Our work explores the mobilities of water across noncircular carbon nanochannels, which may expand the prospect of noncircular nanochannels in scientific studies and practical applications, such as desalination and drug delivery.