Antifungal efficacy of natamycin in experimental fusarium solani keratitis

AIM: To evaluate the efficacy of topical administration Natamycin, which is produced by China, in an experimental rabbit model of Fusarium solani keratitis, to provide experimental basis for the application of clinical safety. · METHODS: Fusarium solani was induced in the right eye of 30 New Zealand rabbits. Forty-eight hours after inoculation, the animals were divided into 3 different treatment groups, 10 rabbit eyes of each group: Group 1 (Natamycin) treated with topical Natamycin, group 2 (Natacyn) treated with topical Natacyn, group 3 (control) treated with topical saline solution. The eyes of each group was examined clinically with slit lamp using ulcer scoring system on day 4, 10, 15, and 21 for status of healing, corneal vascularisation, iritis, hypopyon and macular nebula. The findings were recorded on day 10 and day 21. · RESULTS: Ulcer score on day 10, day 15, day 21: The score of Natamycin group are 1.45±0.16, 1.08±0.11, 0.70±0.40. The score of Natacyn group are 1.35±0.12, 1.10±0.12, 0.65±0.35. the score of control group are 1.30±0.08, 3.63±0.28, 3.80±0.16. Natamycin group and Natacyn group were different from control group(P <0.01). There is no difference between Natamycin group and Natacyn group. Status of healing on day 10 and day 21: The cure rate of the Natamycin group is 90% on day 10, and 100% on day 21. The cure rate of the Natacyn group is 80% on day 10, and 100% on day 21.Natamycin group and Natacyn group were different from control group (P <0.01). There is no difference between Natamycin group and Natacyn group. Corneal vascularisation, iritis, hypopyon and macular nebula on day 10 and day 21: in Natamycin group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 2,0,0,2. In Natacyn group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 1,0,0,2. In control group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 9,9,8,9.Natamycin group and Natacyn group were different from control group (P< 0.01). There is no difference between Natamycin group and Natacyn group. · CONCLUSION: Natamycin was found to be effective in fungal keratitis, similar to Natacyn, and it can stop the corner vascularisation, iritis, hypopyon and macular nebula to happen. Natamyin manufactured in China is effective against fungal keratitis, with esay availability and low toxicity in its use.

局部碘酊烧灼联合氟康唑及那特真治疗真菌性角膜溃疡临床护理

目的：探讨局部烧灼联合氟康唑及那特真治疗真菌性角膜溃疡的疗效及护理方法。方法：将107例（109眼）真菌性角膜溃疡患者分为治疗组58例（60眼）与对照组49例（49眼）。治疗组应用氟康唑及那特真治疗，对照组单纯应用氟康唑治疗，并给予精心护理。比较两组治愈率。结果：治疗组治愈率为86．67％，治愈时间为6．0～43．0d，平均16．1d；对照组治愈率为71．43％，治愈时间为17．0～69．0d，平均28．9d。两组比较有显著性差异（P〈0．05）。结论：采用局部碘酊烧灼联合氟康唑及那特真治疗真菌性角膜溃疡，同时施以系统护理，可取得满意效果。

联合治疗真菌性角膜溃疡的效果观察

目的观察角膜溃疡清创、碘酊烧灼联合那他霉素滴眼液和氟康唑滴眼液点眼治疗真菌性角膜溃疡的效果。方法收集真菌性角膜溃疡病人180例,将病人按治疗方法分为A组(75例)、B组(70例)及C组(35例)。所有病人均先行角膜溃疡清创、碘酊烧灼,然后A组采用那他霉素滴眼液和氟康唑滴眼液联合点眼,B组采用那他霉素滴眼液点眼,C组采用氟康唑滴眼液点眼。比较3组病人治愈率、治愈病例的治愈时间和视力变化。结果 A、B组的治愈率高于C组,差异有统计学意义(χ2=9.444、6.285,P<0.05);3组治愈病例的治愈时间分别为(25±4)、(26±5)、(30±12)d,差异无统计学意义(P>0.05);治愈病人视力有不同程度提高。结论角膜溃疡清创、碘酊烧灼联合那他霉素滴眼液及氟康唑滴眼液点眼是治疗真菌性角膜溃疡的一种非常有效的方法。

那特真联合结膜遮盖术治疗真菌性角膜炎

目的:探讨那特真联合结膜遮盖术治疗真菌性角膜炎的疗效.方法:全部病例均先采用那特真滴眼液点眼,对重症角膜溃疡的患者联合结膜瓣遮盖术治疗.结果:21例患者角膜溃疡完全愈合.结论:那特真对真菌性角膜炎有较好的疗效,重症角膜溃疡的患者尽早联合结膜瓣遮盖术,可明显提高治愈率.

纳他霉素滴眼剂对兔眼的刺激性研究

目的探讨纳他霉素滴眼剂对正常兔眼的刺激性。方法将20只新西兰白兔随机均分为那特真组、生理盐水组、纳他霉素滴眼剂组、赋形剂组。每组10只兔眼,每天用药8～10次,每次1滴,连续应用至第21天,停药后观察2 d。采用双盲法用裂隙灯观察兔眼刺激情况并评分。结果各实验组药物对正常兔眼均无刺激性,与生理盐水组比较,均无显著差异。结论纳他霉素滴眼剂对兔眼无刺激性,有着良好的发展前景。