Some new results about the NBU(2) class of life distributions were obtained. Fir stly, it was proved that the decrease with time of the increasing concave orderi ng of the excess lifetime in a renewal process leads to...Some new results about the NBU(2) class of life distributions were obtained. Fir stly, it was proved that the decrease with time of the increasing concave orderi ng of the excess lifetime in a renewal process leads to the NBU(2) property of t he interarrival times. Secondly, the NBU(2) class of life distributions is prove d to be closed under the formation of series systems. Finally, it was also shown that the NBU(2) class is closed under convolution operation.展开更多
Objectives: In order to investigate the role of mono-cytes and human leukocyte antigen (HLA) class II an-tigen in herpes simplex virus-2 (HSV-2) infection, westudied the effect of HSV-2 infection in vitro on theexpres...Objectives: In order to investigate the role of mono-cytes and human leukocyte antigen (HLA) class II an-tigen in herpes simplex virus-2 (HSV-2) infection, westudied the effect of HSV-2 infection in vitro on theexpression of HLA class II antigen on monocytes.Methods: Monocytes were infected with HSV-2(Strain 333). Culture cells were collected 1, 3, 5 and 7days after infection. The levels of expression of HLAclass II antigen were measured by using alkaline phos-phatase antialkaline phosphatase method (APAAP).Results: The levels of the expression of HLA class IIantigen on monocytes significantly decreased on thefirst day of post-infection, and then gradually returnedto levels found in the controls by the 7th day post-infection.Conclusion: HLA class II antigen expression onmonocytes was inhibited with HSV-2 infection, whichmight be one means of virus escape at an early phase.The expression of HLA class II antigen may play animportant role in herpes simplex viurs-2 pathogenic-ity and immunity.展开更多
The scavenger receptor class B type I (SR-BI) is a high-density lipoprotein (HDL) receptor involved in reverse cholesterol transport. Some studies reported the association to be stronger in the presence of diabetes. T...The scavenger receptor class B type I (SR-BI) is a high-density lipoprotein (HDL) receptor involved in reverse cholesterol transport. Some studies reported the association to be stronger in the presence of diabetes. The full length gene encoding SR-BI is comprised in 13 exons that are alternatively spliced to produce two major transcripts: the full length SR-BI and the splice variant SR-BII, in which exon 12 is skipped. Considering that type 2 diabetes status is characterized by changes in the concentration of plasma lipids, modifications in lipoprotein size and composition, which may be important modulators of the SR-BI expression;the aims of the study were to examine the influence of SR-BI polymorphism (rs838895) on lipid profile and SR-BI mRNA expression in a population of diabetic patients living in Juana Koslay City. Blood samples were drawn from controls (n = 40) and Type 2 diabetic patients (n = 66) and DNA and total RNA were obtained. SR-BI mRNA expression was measured by RT-PCR and SR-BI polymorphism was detected by Tetra Primer ARMSPCR. Compared to controls, diabetic patients had higher fasting serum glucose, glycated hemoglobin, triglycerides, total cholesterol, lowdensity lipoprotein cholesterol, and lower highdensity lipoprotein cholesterol. SR-BI mRNA expression was lower in T2DM when compared to controls, suggesting that the hyperglycemia presents in T2DM patients down-regulates SR-BI mRNA expression. Interestingly, we found that decreased SR-BI expression resulted in markedly increased plasma LDL concentrations in T2DM subjects, and the overexpression of SRBII isoform is responsible for the markedly increased plasma LDL-c concentrations. The polymorphism (rs838895) did not modify the mRNA level of SR-BI in leucocytes from control and diabetic patients. This study provides novel evidence suggesting that hyperglycemia may affect reverse cholesterol transport by controlling SRBI expression in diabetic patients. LDL cholesterol levels are associated with low SR-BI mRNA expression in T2DM.展开更多
the widely discussed study of word class categorization has a long history of more than 2000 years,which is known as the study of the“God Particles”in language.As a typical analytic language,Modern Chinese,due to it...the widely discussed study of word class categorization has a long history of more than 2000 years,which is known as the study of the“God Particles”in language.As a typical analytic language,Modern Chinese,due to its lack of morphological changes,is challenged by a thorny problem of word classes especially when it comes to the criteria for word class identification and the treat⁃ment of multiple class membership.As such,all the controversies eventually give rise to some contradiction and confusion in word class labeling in Modern Chinese and Chinese-English dictionaries.As an important grammatical means in Chinese and the focus of lexicology and rhetorics,total reduplication lexemes serve as an essential part of Chinese-English dictionaries with complex and diverse word classes.Guided by the Two-level Word Class Categorization Theory,this thesis focuses on the word class labeling of total reduplication lexemes in New Century Chinese-English Dictionary(2nd edition)backed by large-scale balanced Modern Chi⁃nese corpora.With an innovative theoretical perspective,this study not only contributes to the word class labeling of total reduplica⁃tion lexemes and even sheds light on the compilation of Chinese-English dictionaries,but also drives the study of Modern Chinese word classes in the long term.展开更多
The statistical study of F2 layer critical frequency at Dakar station from 1971 to 1996 is carried out. This paper shows foF2 statistical diurnal for all geomagnetic activities and all seasons and that during solar ma...The statistical study of F2 layer critical frequency at Dakar station from 1971 to 1996 is carried out. This paper shows foF2 statistical diurnal for all geomagnetic activities and all seasons and that during solar maximum and minimum phases. It emerges that foF2 diurnal variation graphs at Dakar station exhibits the different types of foF2 profiles in African EIA regions. The type of profile depends on solar activity, season and solar phase. During solar minimum and under quiet time condition, data show?the signature of a strength electrojet that is coupled with intense counter electrojet in the afternoon. Under disturbed conditions,?mean intense electrojet is observed in winter?during fluctuating and recurrent activities. Intense counter electrojet is seen under fluctuating and shock activities in all seasons coupled with strength electrojet in autumn. In summer?and spring under all geomagnetic activity condition, there is intense counter electrojet. During solar maximum, in summer and spring there is no electrojet under geomagnetic activity conditions.?Winter shows a mean intense electrojet. Winter and autumn are marked by the signature of the reversal electric field.展开更多
克隆了乌骨鸡(BF2*SI)和珍珠鸡(BF2*NM)群主要组织相容性复合体I(MHC class I)和β微球蛋白(β2m)基因,分析了其分子特征与等位基因多态性。BF2*SI相互间氨基酸同源率为75.5%~93.9%,保留了人HLA-A2与抗原多肽结合的7个关键性氨基酸。BF2...克隆了乌骨鸡(BF2*SI)和珍珠鸡(BF2*NM)群主要组织相容性复合体I(MHC class I)和β微球蛋白(β2m)基因,分析了其分子特征与等位基因多态性。BF2*SI相互间氨基酸同源率为75.5%~93.9%,保留了人HLA-A2与抗原多肽结合的7个关键性氨基酸。BF2*NM相互间氨基酸同源率为81.1%~98.5%,保留了人HLA-A2与抗原多肽结合的6个关键性氨基酸。BF2*SI在α1和α2区(抗原多肽结合区,PBD)有24个高置换率位点,置换率最高的为69位和9位。BF2*NM在PBD区共有6个高置换率位点。BF2*SIPBD发生氨基酸置换的位点数大于来航鸡BF2,BF2*NMPBD区氨基酸置换的位点数和置换率则远远小于来航鸡BF2。根据同源率,将BF2*SIα1区分为4类,α2区分为3类,α3区分为3类,并由此聚类为5个系谱(A^E)。将BF2*NMα1区分为3类,α2区分为3类,α3区分为1类,并由此聚类为3个系谱(A^C)。比较发现BF2*03SI、BF2*04SI和BF2*05NM的α1区与抗马立克氏病的BF2*21同源率最高(分别为86.4%、86.4%和87.5%);BF2*05SI和BF2*05NM的α2区与BF2*21同源率最高(均为93.4%)。另外,根据成熟肽区的氨基酸序列可将乌骨、珍珠鸡β2m分为两类,第一类和来航鸡β2m(M84767)氨基酸序列完全相同,第二类与第一类相比,氨基酸序列相互间同源率为85.7%。结果揭示了各类鸡的MHCⅠ和β2m基因具有品种分子特征。展开更多
目的对混合牙列期与恒牙列早期安氏Ⅱ类2分类错下颌生长发育特点进行分析比较。方法研究样本包括95名安氏Ⅱ类2分类错青少年与75名正常青少年。对每个对象拍摄手腕骨片和头颅侧位片,进行X线片头影测量分析。结果混合牙列期到恒牙...目的对混合牙列期与恒牙列早期安氏Ⅱ类2分类错下颌生长发育特点进行分析比较。方法研究样本包括95名安氏Ⅱ类2分类错青少年与75名正常青少年。对每个对象拍摄手腕骨片和头颅侧位片,进行X线片头影测量分析。结果混合牙列期到恒牙列早期的变化如下。1)角度:对照组SNB、S-Ba-Go增大,Ar-Go-Me、SN-MP、NSGn减小;实验组SNB、Ar-Go-Me、Cd-Go-Me、SN-MP、S-Ar-Go、S-Ba-Go变化无显著性。实验组Y轴角、NSGn增大,对照组Y轴变化无显著性。2)颏部:实验组除了颏凹陷增大外,其余各项指标变化差异无统计学意义。对照组除颏曲度减小外,颏高、颏厚、颏凹陷、颏厚/颏高、SL、Pog to NB增大。3)线距:对照组Cd-Go、Gn-Cd、Go-Me、Ar-Pog、Ar-Go的生长量大于实验组。结论本研究提出的混合牙列期与恒牙列早期安氏Ⅱ类2分类错下颌的生长发育特点有助于临床医生治疗中作出合理的计划。展开更多
文摘Some new results about the NBU(2) class of life distributions were obtained. Fir stly, it was proved that the decrease with time of the increasing concave orderi ng of the excess lifetime in a renewal process leads to the NBU(2) property of t he interarrival times. Secondly, the NBU(2) class of life distributions is prove d to be closed under the formation of series systems. Finally, it was also shown that the NBU(2) class is closed under convolution operation.
文摘Objectives: In order to investigate the role of mono-cytes and human leukocyte antigen (HLA) class II an-tigen in herpes simplex virus-2 (HSV-2) infection, westudied the effect of HSV-2 infection in vitro on theexpression of HLA class II antigen on monocytes.Methods: Monocytes were infected with HSV-2(Strain 333). Culture cells were collected 1, 3, 5 and 7days after infection. The levels of expression of HLAclass II antigen were measured by using alkaline phos-phatase antialkaline phosphatase method (APAAP).Results: The levels of the expression of HLA class IIantigen on monocytes significantly decreased on thefirst day of post-infection, and then gradually returnedto levels found in the controls by the 7th day post-infection.Conclusion: HLA class II antigen expression onmonocytes was inhibited with HSV-2 infection, whichmight be one means of virus escape at an early phase.The expression of HLA class II antigen may play animportant role in herpes simplex viurs-2 pathogenic-ity and immunity.
文摘The scavenger receptor class B type I (SR-BI) is a high-density lipoprotein (HDL) receptor involved in reverse cholesterol transport. Some studies reported the association to be stronger in the presence of diabetes. The full length gene encoding SR-BI is comprised in 13 exons that are alternatively spliced to produce two major transcripts: the full length SR-BI and the splice variant SR-BII, in which exon 12 is skipped. Considering that type 2 diabetes status is characterized by changes in the concentration of plasma lipids, modifications in lipoprotein size and composition, which may be important modulators of the SR-BI expression;the aims of the study were to examine the influence of SR-BI polymorphism (rs838895) on lipid profile and SR-BI mRNA expression in a population of diabetic patients living in Juana Koslay City. Blood samples were drawn from controls (n = 40) and Type 2 diabetic patients (n = 66) and DNA and total RNA were obtained. SR-BI mRNA expression was measured by RT-PCR and SR-BI polymorphism was detected by Tetra Primer ARMSPCR. Compared to controls, diabetic patients had higher fasting serum glucose, glycated hemoglobin, triglycerides, total cholesterol, lowdensity lipoprotein cholesterol, and lower highdensity lipoprotein cholesterol. SR-BI mRNA expression was lower in T2DM when compared to controls, suggesting that the hyperglycemia presents in T2DM patients down-regulates SR-BI mRNA expression. Interestingly, we found that decreased SR-BI expression resulted in markedly increased plasma LDL concentrations in T2DM subjects, and the overexpression of SRBII isoform is responsible for the markedly increased plasma LDL-c concentrations. The polymorphism (rs838895) did not modify the mRNA level of SR-BI in leucocytes from control and diabetic patients. This study provides novel evidence suggesting that hyperglycemia may affect reverse cholesterol transport by controlling SRBI expression in diabetic patients. LDL cholesterol levels are associated with low SR-BI mRNA expression in T2DM.
文摘the widely discussed study of word class categorization has a long history of more than 2000 years,which is known as the study of the“God Particles”in language.As a typical analytic language,Modern Chinese,due to its lack of morphological changes,is challenged by a thorny problem of word classes especially when it comes to the criteria for word class identification and the treat⁃ment of multiple class membership.As such,all the controversies eventually give rise to some contradiction and confusion in word class labeling in Modern Chinese and Chinese-English dictionaries.As an important grammatical means in Chinese and the focus of lexicology and rhetorics,total reduplication lexemes serve as an essential part of Chinese-English dictionaries with complex and diverse word classes.Guided by the Two-level Word Class Categorization Theory,this thesis focuses on the word class labeling of total reduplication lexemes in New Century Chinese-English Dictionary(2nd edition)backed by large-scale balanced Modern Chi⁃nese corpora.With an innovative theoretical perspective,this study not only contributes to the word class labeling of total reduplica⁃tion lexemes and even sheds light on the compilation of Chinese-English dictionaries,but also drives the study of Modern Chinese word classes in the long term.
文摘The statistical study of F2 layer critical frequency at Dakar station from 1971 to 1996 is carried out. This paper shows foF2 statistical diurnal for all geomagnetic activities and all seasons and that during solar maximum and minimum phases. It emerges that foF2 diurnal variation graphs at Dakar station exhibits the different types of foF2 profiles in African EIA regions. The type of profile depends on solar activity, season and solar phase. During solar minimum and under quiet time condition, data show?the signature of a strength electrojet that is coupled with intense counter electrojet in the afternoon. Under disturbed conditions,?mean intense electrojet is observed in winter?during fluctuating and recurrent activities. Intense counter electrojet is seen under fluctuating and shock activities in all seasons coupled with strength electrojet in autumn. In summer?and spring under all geomagnetic activity condition, there is intense counter electrojet. During solar maximum, in summer and spring there is no electrojet under geomagnetic activity conditions.?Winter shows a mean intense electrojet. Winter and autumn are marked by the signature of the reversal electric field.
文摘克隆了乌骨鸡(BF2*SI)和珍珠鸡(BF2*NM)群主要组织相容性复合体I(MHC class I)和β微球蛋白(β2m)基因,分析了其分子特征与等位基因多态性。BF2*SI相互间氨基酸同源率为75.5%~93.9%,保留了人HLA-A2与抗原多肽结合的7个关键性氨基酸。BF2*NM相互间氨基酸同源率为81.1%~98.5%,保留了人HLA-A2与抗原多肽结合的6个关键性氨基酸。BF2*SI在α1和α2区(抗原多肽结合区,PBD)有24个高置换率位点,置换率最高的为69位和9位。BF2*NM在PBD区共有6个高置换率位点。BF2*SIPBD发生氨基酸置换的位点数大于来航鸡BF2,BF2*NMPBD区氨基酸置换的位点数和置换率则远远小于来航鸡BF2。根据同源率,将BF2*SIα1区分为4类,α2区分为3类,α3区分为3类,并由此聚类为5个系谱(A^E)。将BF2*NMα1区分为3类,α2区分为3类,α3区分为1类,并由此聚类为3个系谱(A^C)。比较发现BF2*03SI、BF2*04SI和BF2*05NM的α1区与抗马立克氏病的BF2*21同源率最高(分别为86.4%、86.4%和87.5%);BF2*05SI和BF2*05NM的α2区与BF2*21同源率最高(均为93.4%)。另外,根据成熟肽区的氨基酸序列可将乌骨、珍珠鸡β2m分为两类,第一类和来航鸡β2m(M84767)氨基酸序列完全相同,第二类与第一类相比,氨基酸序列相互间同源率为85.7%。结果揭示了各类鸡的MHCⅠ和β2m基因具有品种分子特征。
文摘目的对混合牙列期与恒牙列早期安氏Ⅱ类2分类错下颌生长发育特点进行分析比较。方法研究样本包括95名安氏Ⅱ类2分类错青少年与75名正常青少年。对每个对象拍摄手腕骨片和头颅侧位片,进行X线片头影测量分析。结果混合牙列期到恒牙列早期的变化如下。1)角度:对照组SNB、S-Ba-Go增大,Ar-Go-Me、SN-MP、NSGn减小;实验组SNB、Ar-Go-Me、Cd-Go-Me、SN-MP、S-Ar-Go、S-Ba-Go变化无显著性。实验组Y轴角、NSGn增大,对照组Y轴变化无显著性。2)颏部:实验组除了颏凹陷增大外,其余各项指标变化差异无统计学意义。对照组除颏曲度减小外,颏高、颏厚、颏凹陷、颏厚/颏高、SL、Pog to NB增大。3)线距:对照组Cd-Go、Gn-Cd、Go-Me、Ar-Pog、Ar-Go的生长量大于实验组。结论本研究提出的混合牙列期与恒牙列早期安氏Ⅱ类2分类错下颌的生长发育特点有助于临床医生治疗中作出合理的计划。
