Background:Carcinosarcomas are rare,aggressive malignancies that can arise in the nasal cavity and paranasal sinuses.There are limited outcome data available.Accordingly,we sought to use the National Cancer Database(N...Background:Carcinosarcomas are rare,aggressive malignancies that can arise in the nasal cavity and paranasal sinuses.There are limited outcome data available.Accordingly,we sought to use the National Cancer Database(NCDB)to characterize patient demographics and outcomes.Method:A retrospective analysis of the NCDB from 2004 to 2016 for patients with sinonasal carcinosarcoma was conducted.Results:Thirty patients were included.The patients were predominantly male(n=20),white(n=23),and privately insured(n=15),with an average age of 62.4 years.The nasal cavity was the most common subsite(n=14),followed by the maxillary sinus(n=8).Most patient were treated with surgery followed by radiation(n=23),with the remaining undergoing surgery alone(n=4),radiation alone(n=2),or no treatment(n=1).One-third(n=10)received adjuvant chemotherapy.The 1-and 5-year overall survival(OS)in the cohort were 79.2%and 43.3%,respectively.Univariate log-rank testing showed OS varied based on intervention(P<0.029),sex(P<0.042),and age(P<0.025),while on multivariate analysis none of these factors independently predicted OS.Conclusions:We describe the demographics and presenting features of a national cohort of sinonasal carcinosarcoma patients.Future research is needed to identify predictors of overall survival,and to assess the optimal roles for radiation and systemic chemotherapy.展开更多
近年来,我国肺癌的发病率和死亡率持续增高,严重危害国民健康。随着计算机信息技术、数据挖掘的高速发展,世界各地建立大量临床数据库,已收集、存储和管理数量日益庞大、种类日益繁多的肺癌相关资料,为肺癌研究提供宝贵而丰富的数据来...近年来,我国肺癌的发病率和死亡率持续增高,严重危害国民健康。随着计算机信息技术、数据挖掘的高速发展,世界各地建立大量临床数据库,已收集、存储和管理数量日益庞大、种类日益繁多的肺癌相关资料,为肺癌研究提供宝贵而丰富的数据来源。本研究介绍了目前全球部分常用的肿瘤数据库,并列举其在肺癌研究方面的应用,为肺癌研究应用数据库提供思路。比较美国国立癌症研究所的"监测,流行病学和结果"数据库(surveillance, epidemiology and end results database, SEER)和美国国家癌症数据库(National Cancer Data Base, NCDB)的不同点,介绍了我国肿瘤数据库的发展现状,为我国乃至全球的肿瘤数据的发展提出展望。展开更多
文摘Background:Carcinosarcomas are rare,aggressive malignancies that can arise in the nasal cavity and paranasal sinuses.There are limited outcome data available.Accordingly,we sought to use the National Cancer Database(NCDB)to characterize patient demographics and outcomes.Method:A retrospective analysis of the NCDB from 2004 to 2016 for patients with sinonasal carcinosarcoma was conducted.Results:Thirty patients were included.The patients were predominantly male(n=20),white(n=23),and privately insured(n=15),with an average age of 62.4 years.The nasal cavity was the most common subsite(n=14),followed by the maxillary sinus(n=8).Most patient were treated with surgery followed by radiation(n=23),with the remaining undergoing surgery alone(n=4),radiation alone(n=2),or no treatment(n=1).One-third(n=10)received adjuvant chemotherapy.The 1-and 5-year overall survival(OS)in the cohort were 79.2%and 43.3%,respectively.Univariate log-rank testing showed OS varied based on intervention(P<0.029),sex(P<0.042),and age(P<0.025),while on multivariate analysis none of these factors independently predicted OS.Conclusions:We describe the demographics and presenting features of a national cohort of sinonasal carcinosarcoma patients.Future research is needed to identify predictors of overall survival,and to assess the optimal roles for radiation and systemic chemotherapy.
文摘近年来,我国肺癌的发病率和死亡率持续增高,严重危害国民健康。随着计算机信息技术、数据挖掘的高速发展,世界各地建立大量临床数据库,已收集、存储和管理数量日益庞大、种类日益繁多的肺癌相关资料,为肺癌研究提供宝贵而丰富的数据来源。本研究介绍了目前全球部分常用的肿瘤数据库,并列举其在肺癌研究方面的应用,为肺癌研究应用数据库提供思路。比较美国国立癌症研究所的"监测,流行病学和结果"数据库(surveillance, epidemiology and end results database, SEER)和美国国家癌症数据库(National Cancer Data Base, NCDB)的不同点,介绍了我国肿瘤数据库的发展现状,为我国乃至全球的肿瘤数据的发展提出展望。
