To test whether the novel tumor-suppressor candidate gene-ndr2 is also differentially expressed between osteoarthritis synovium cells (OASC) and rheumatoid arthritis synovium fibroblasts (RASF), and whether ndr2 can s...To test whether the novel tumor-suppressor candidate gene-ndr2 is also differentially expressed between osteoarthritis synovium cells (OASC) and rheumatoid arthritis synovium fibroblasts (RASF), and whether ndr2 can suppress the growth of RASF in vitro. Methods: Dot blotting, cell culture and gene transfection, cell cycle nalysis techniques were applied to investigate the effect of ndr2 on the cell phenotype and cell cycles. Results: ndr2 is expressed in OASC but absent in RASF. Transient transfection of ndr2 into RASF can suppress the growth of RASF from phenotype observation. Cell cycle analysis showed that apoptotic peaks can be detected in RASF cells transfected with ndr2 gene. Conclusion: Novel tumor suppressor candidate ndr2 is not only differentially expressed between OASC and RASF but also can induce the apoptosis of RASF in vitro.展开更多
目前共振隧穿二极管(RTD)多值逻辑电路研究采用多个MOSFETs组合,以逼近RTD特性,这是现有逻辑功能验证的不足。针对该问题,通过建立对称双势垒RTD电子输运的解析模型,进而采用SILVACO TCAD对Ga As/Al Ga As基对称DBS RTD器件的电学特性...目前共振隧穿二极管(RTD)多值逻辑电路研究采用多个MOSFETs组合,以逼近RTD特性,这是现有逻辑功能验证的不足。针对该问题,通过建立对称双势垒RTD电子输运的解析模型,进而采用SILVACO TCAD对Ga As/Al Ga As基对称DBS RTD器件的电学特性进行仿真实验研究。根据仿真实验的结果分析总结了势阱和势垒宽度对Ga As/Al Ga As基对称DBS RTD负阻特性影响的规律,并根据MVL电路设计应用的低压、低功耗、适当峰谷电流比和工艺可实现性等要求,通过大量的仿真优化实验提出采用Ga As/Al Ga As基对称DBS RTD实现多值逻辑电路设计所需的对称DBS RTD器件设计参数窗口。展开更多
文摘To test whether the novel tumor-suppressor candidate gene-ndr2 is also differentially expressed between osteoarthritis synovium cells (OASC) and rheumatoid arthritis synovium fibroblasts (RASF), and whether ndr2 can suppress the growth of RASF in vitro. Methods: Dot blotting, cell culture and gene transfection, cell cycle nalysis techniques were applied to investigate the effect of ndr2 on the cell phenotype and cell cycles. Results: ndr2 is expressed in OASC but absent in RASF. Transient transfection of ndr2 into RASF can suppress the growth of RASF from phenotype observation. Cell cycle analysis showed that apoptotic peaks can be detected in RASF cells transfected with ndr2 gene. Conclusion: Novel tumor suppressor candidate ndr2 is not only differentially expressed between OASC and RASF but also can induce the apoptosis of RASF in vitro.
文摘目前共振隧穿二极管(RTD)多值逻辑电路研究采用多个MOSFETs组合,以逼近RTD特性,这是现有逻辑功能验证的不足。针对该问题,通过建立对称双势垒RTD电子输运的解析模型,进而采用SILVACO TCAD对Ga As/Al Ga As基对称DBS RTD器件的电学特性进行仿真实验研究。根据仿真实验的结果分析总结了势阱和势垒宽度对Ga As/Al Ga As基对称DBS RTD负阻特性影响的规律,并根据MVL电路设计应用的低压、低功耗、适当峰谷电流比和工艺可实现性等要求,通过大量的仿真优化实验提出采用Ga As/Al Ga As基对称DBS RTD实现多值逻辑电路设计所需的对称DBS RTD器件设计参数窗口。
