The natural product, neoclausenamide was synthesized through the 'biomimetic' route and the stereoselective reduction of the ketone group wherein were described.
An intramolecular nucleophilic substitution of carbon anion to cyclic sulfate was first employed in asymmetric synthesis of (+)-(3R, 4S, 5R, 7S)-neoclausenamide 1 which is a novel hepatoprotective lactam isolated from...An intramolecular nucleophilic substitution of carbon anion to cyclic sulfate was first employed in asymmetric synthesis of (+)-(3R, 4S, 5R, 7S)-neoclausenamide 1 which is a novel hepatoprotective lactam isolated from the dry leaves of Chinese folk medicine Clausena lansium (Lour) Skeel. The regioselectivity of beta-attack to this cyclic sulfate, just like its epoxide counterpart was attributed to the increased reactivity of beta-position by the phenyl group.展开更多
Neoclausenamide with lowering effect on the elevated SGPT levels was isolated from leaves of Clausena Lansium (lour) Skeels. Its content in the plant is less than 0.01%. For more intense pharmacological studies, large...Neoclausenamide with lowering effect on the elevated SGPT levels was isolated from leaves of Clausena Lansium (lour) Skeels. Its content in the plant is less than 0.01%. For more intense pharmacological studies, larger amount of展开更多
文摘The natural product, neoclausenamide was synthesized through the 'biomimetic' route and the stereoselective reduction of the ketone group wherein were described.
文摘An intramolecular nucleophilic substitution of carbon anion to cyclic sulfate was first employed in asymmetric synthesis of (+)-(3R, 4S, 5R, 7S)-neoclausenamide 1 which is a novel hepatoprotective lactam isolated from the dry leaves of Chinese folk medicine Clausena lansium (Lour) Skeel. The regioselectivity of beta-attack to this cyclic sulfate, just like its epoxide counterpart was attributed to the increased reactivity of beta-position by the phenyl group.
文摘Neoclausenamide with lowering effect on the elevated SGPT levels was isolated from leaves of Clausena Lansium (lour) Skeels. Its content in the plant is less than 0.01%. For more intense pharmacological studies, larger amount of
