A new horizon for neuroscience:terahertz biotechnology in brain research

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry.Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin deficit.In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases.Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications.However,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications.This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

The Role of Impulsivity and Addiction in Gambling Behaviors: How Applied Neuroscience Research Can Help in the Monitoring and Management of Mental Health Issues

One in five Americans experience symptoms associated with at least one mental health disorder every year. These include behavioral addictions, which have long been overlooked despite their similar neural bases with substance addictions. Gambling addiction, a type of behavioral addiction, deserves particular attention given the significant negative effects, this addiction has on financial and interpersonal health. The purpose of this paper is to review the available literature concerning the behavioral and neural processes involved in gambling addiction, including: the anticipation of reward, the role of dopamine, and the neural substrates of the decision-making processes involved in gambling addiction. Market research has also identified solutions that integrate applied neuroscience and self-tracking systems to monitor and manage mental health issues associated with gambling addiction. The authors then propose a gambling treatment-focused mobile app solution that addresses outstanding issues with a special design aimed at reversing plasticity in order to relieve the effects of gambling addiction. .

Integrative multi-omics and systems bioinformatics in translational neuroscience:A data mining perspective

Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed neuroinformatics.Data mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative diseases.Importantly,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain profile.In this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple sclerosis.We then discuss multi-omics integration approaches,including independent biological integration and unsupervised integration methods,for more intuitive and informative interpretation of the biological data obtained across different omics layers.We further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain networks.Finally,we recommend a combination of high dimensional bioinformatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease mechanisms.We conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personalized medicine.

对英文科技期刊约稿的初浅认识和尝试--以Journal of Translational Neuroscience为例

目的作为一本新创的英文期刊,Journal of Translational Neuroscience杂志需要尽快提升其学术水平,扩大其社会影响力,以期能迅速在国际专业学术期刊界占有一席之地,通过约稿获得高质量的学术论文就显得至关重要。方法笔者从找准期刊学术定位、采取灵活多样的约稿方式、分析解决约稿过程中可能存在的问题以及如何做好约稿后续服务工作等几个方面入手,初浅分析探讨了关于期刊约稿的方式方法。结果通过期刊定位准确锁定目标作者群,依托自身优势资源,参与学术会议,通过编委约稿以及提供优质的后续服务等方法获得稳定的高质量作者群,从而获得持续的优秀稿源。结论拥有持续的高质量稿件是促使期刊进入良性循环的重要保障,通过约稿可以解决新创办的期刊无稿可用和缺少优秀稿件的难题,推动期刊走出困境,渐入正轨。

Research trends, hot spots and prospects for necroptosis in the field of neuroscience

There are two types of cell death-apoptosis and necrosis. Apoptosis is cell death regulated by cell signaling pathways, while necrosis has until recently been considered a passive mechanism of cell death caused by environmental pressures. However, recent studies show that necrosis can also be regulated by specific cell signaling pathways. This mode of death, termed necroptosis, has been found to be related to the occurrence and development of many diseases. We used bibliometrics to analyze the global output of literature on necroptosis in the field of neuroscience published in the period 2007–2019 to identify research hotspots and prospects. We included 145 necroptosisrelated publications and 2239 references published in the Web of Science during 2007–2019. Visualization analysis revealed that the number of publications related to necroptosis has increased year by year, reaching a peak in 2019. China is the country with the largest number of publications. Key word and literature analyses demonstrated that mitochondrial function change, stroke, ischemia/reperfusion and neuroinflammation are likely the research hotspots and future directions of necroptosis research in the nervous system. The relationship between immune response-related factors, damage-associated molecular patterns, pathogen-associated molecular patterns and necroptosis may become a potential research hotspot in the future. Taken together, our findings suggest that although the inherent limitations of bibliometrics may affect the accuracy of the literature-based prediction of research hotspots, the results obtained from the included publications can provide a reference for the study of necroptosis in the field of neuroscience.

A bright future for the tree shrew in neuroscience research:Summary from the inaugural Tree Shrew Users Meeting

Tree shrews(Tupaia spp.)have been used in neuroscience research since the 1960s due to their evolutionary proximity to primates.The use of and interest in this animal model have recently increased,in part due to the adaptation of modern neuroscience tools in this species.These tools include quantitative behavioral assays,calcium imaging,optogenetics and transgenics.To facilitate the exchange and development of these new technologies and associated research findings,we organized the inaugural“Tree Shrew Users Meeting”which was held online due to the COVID-19 pandemic.Here,we review this meeting and discuss the history of tree shrews as an animal model in neuroscience research and summarize the current themes being investigated using this animal,as well as future directions.

Fluorescence Nanoscopy in Neuroscience

Fluorescence nanoscopy provides imaging techniques that overcome the diffraction-limited resolution barrier in light microscopy,thereby opening up a new area of research in biomedical imaging in fields such as neuroscience.Here,we review the foremost fluorescence nanoscopy techniques,including descriptions of their applications in elucidating protein architectures and mobility,the real-time determination of synaptic parameters involved in neural processes,three-dimensional imaging,and the tracking of nanoscale neural activity.We conclude by discussing the prospects of fluorescence nanoscopy,with a particular focus on its deployment in combination with related techniques(e.g.,machine learning)in neuroscience.

Neuroscience for Architecture:How Building Design Can Influence Behaviors and Performance

The purpose of this paper is to discuss recent findings in neuroscience that can be useful to architecture.Knowing the working patterns of the brain and how space affects cerebral functions can help architects design buildings that improve the user’s behavior,performance and well-being.The built environment has a direct impact on the human brain.Social relations,focus,cognition,creativity,memory and well-being can be influenced by the surrounding physical space.Although it is not possible to create the perfect room,the space can be used in a strategic way,depending on the task that individuals are supposed to do there and depending on the people(age,gender,culture)who will make use of the space.Schools can be designed in a way to improve cognition,learning and memorization;hospital buildings can help improving recovery;workspaces can improve performance,creativity and collaboration.Above all,all spaces of long occupation should be designed in a way to improve well-being.How can architecture change automatic behaviors and nudge people to behave in a healthier way?Can architects create buildings and cities that improve socialization and happiness?Can criminality levels drop due to changes on the way the environments are designed?These are some of the questions that will be discussed in this paper.

Decision-Making of Enterprise Leaders From the Perspective of Organizational Neuroscience

Organizational neuroscience(ON)is an emerging discipline that provides effective interpretations and greater understanding of modern organizational operation.ON covers a variety of disciplines,including physiological psychology,cognitive psychology,and neuropsychology,as well as the study of management,industrial/organizational psychology,and consultants.So far,ON has made many contributions to organization studies.Given the rapid development of neuroscience,many scholars have studied the leadership behaviors of organizational leaders from this emerging perspective.However,not all neuroscience studies investigate the differences between specific leaders.In particular,previous neuroscience studies have not touched on the neuroscientific effects found during the issue of and response to instructions between leaders and followers.This study extends previous ON studies to other organizational factors,including leadership style,organizational atmosphere,and job performance.In the future,an empirical study will be conducted to guide the practical applications of ON.

The Effects of Pain Neuroscience Education with Conventional Physical Therapy on Chronic Plantar Fasciitis: A Case Study

Background and Purpose: Plantar Fasciitis (PF) is a condition that affects the foot and causes complaints such as pain and stiffness. The most common symptom of this condition is pain. There are many treatment options to deal with this condition, such as conservative therapy, medications, and surgical interventions in rare cases. This case study aims to investigate the potential impact of pain neuroscience education (PNE), combined with a conventional Physical Therapy (PT) program on a 37-year-old-patient with chronic plantar fasciitis. Case description: A 37-year-old male health care professional presented to an outpatient physical therapy clinic with a diagnosis of chronic PF for around two years. The participant had tried several treatment options with no improvement of his symptoms. After undergoing a physical therapy evaluation, he was given a plan of care for twelve sessions by a skilled physical therapist for a six-week period, with each session consisting of 30 minutes of conventional PT, followed by 5 to 15 minutes of PNE. Results: After completing the prescribed plan of care, the patient reported a reduction in subjective symptoms via the Visual Analog Scale (VAS). He also reported improvement with symptoms and functional independence via the Foot Function Index (FFI). The patient reported no change in the quality of sleep via Pittsburg Sleep Quality Index (PSQI). Lastly, he demonstrated no objective improvement in foot pressure with the Navicular Drop Test. Discussion: This case report indicates that PNE, combined with conventional PT for PF can have a positive impact on subjective pain and foot function. PNE should involve many topics about the physiology of pain and the nervous system and should be administered by a certified therapeutic pain specialist. Further studies are recommended to investigate the impact of this intervention in combination with traditional PT for PF in larger populations.

Anatomizing the “King of Neurosciences”

The human nucleus accumbens(NA), a major part of the ventral striatum, is the area of continuity between the putamen and head of the caudate nucleus. It consists of two parts, a shell laterally and a core medially. The first is mainly connected to the limbic system and the second to the extrapyramidal motor system. The NA, a major pleasure center of the human brain, acts as a limbic-motor interface and is involved in several cognitive, emotional and psychomotor functions. It has a modulating function in the amygdala-basal gangliaprefrontal cortex circuit. It is considered as the neural interface between motivation and action. Further, it is a principal modulator of the reward circuits and supplies motor expression to emotional responses. Such a clinical significance could easily explain the intense work taking place in the respective field of basic research. Its exceptional clinical importance justifies the title of the "King of Neurosciences" for this nucleus. Purpose of this editorial is to review the "informational paths" left behind by the few researchers who tried to explore the architecture(gross anatomy) of this ‘kingdom'. The first anatomical study focused on this nucleus came from Neto et al. The most extensive study of the NA gross, imaging, stereotactic and neurosurgical anatomy so far,came from the research efforts of Mavridis et al.

Chinese Society of Neuroscience & Psychiatry (CSNP) Notifications of the 16^th National Academic Conference

"The 16^th Chinese Society of Neuroscience & Psychiatry (CSNP)National Academic Conference", sponsored by Chinese Society of Neuroscience & Psychiatry, co-sp on sored by Shanghai Mentai Health Center Affiliated to Shanghai Jiao Tong Un iversity School of Medicine,Harbin First Specialized Hospital, will be held on June 27-29, 2019 at Rong Chuang Wanda Vista Hotel, Harbin. The conference will bring communication of the latest advances of mental disorders through keynote talks, forums, symposiums, oral reports, and poster presentations.

Neuroscience Events in September

April 20-21, 2010, Roche Forum Buonas, Switzerland The third Roche-Nature Medicine Translational Neuroscience Symposium brings together leading scientists from around the world to present novel technologies that are expected to revolutionise translational neuroscience. The

NEUROSCIENCE BULLETIN

The Official Journal of The Chinese Neuroscience SocietySubmit NowNeuroscience Bulletin publishes papers of various topics on neuroscience and focuses on potential disease implications on the nervous system,and molecula r,cellular,or developmental neuroscience using multidisciplinary approaches and functional strategies.