CBSD(Component Based Software Development)在嵌入式开发领域正逐步得到应用,软件构件的非功能属性(Non-FunctionalAttribute,NFA)对开发成功与否至关重要。现有的模型专注于构件复用框架的建立,通过建立一些框架模型进行定性的描述,...CBSD(Component Based Software Development)在嵌入式开发领域正逐步得到应用,软件构件的非功能属性(Non-FunctionalAttribute,NFA)对开发成功与否至关重要。现有的模型专注于构件复用框架的建立,通过建立一些框架模型进行定性的描述,缺乏量化的评定。该文通过建立一个层次分析模型,对影响嵌入式软件构件的NFA的各种不可度量的模糊描述,细分为每一个都可以进行测量的子属性,根据考察构件所应用领域的侧重点不同,赋予不同属性不同的影响权系数,进而计算出一个描述NFA的数值,在实际工程中可以作为构件NFA的考察指标。展开更多
Background Congenital heart disease （CHD） is a diverse group of diseases determined by genetic and environmental factors. Considerable research has been done on genes associated with the development of the heart. Re...Background Congenital heart disease （CHD） is a diverse group of diseases determined by genetic and environmental factors. Considerable research has been done on genes associated with the development of the heart. Recently, focus is on the role of transcription factor NFATcl in the development of proper valve and septa. As part of a larger study, high density single nucleotide polymorphism （SNP） scanning was used to explore the relationship between NFATcl gene polymorphism and susceptibility to ventricular septal defect （VSD） in the Chinese Hart population. Methods One hundred and ninety-two pediatric patients with congenital VSD and 192 matching healthy control subjects were studied. The haplotype reconstructions were calculated by PHASE2.0 software. Haploview software was used to perform linkage disequilibrium assessment and define haplotype blocks. The algorithm used for defining the blocks was the confidence interval method. Results The NFATcl gene region can be divided into 11 haplotype blocks. Strong linkage disequilibrium existed within blocks 6, 8, 9, and 11. Three SNPs （rs7240256, rs11665469, and rs754505） within the NFATcl gene had significant correlation with VSD by single marker association analysis. In addition, two haplotypes correlated with VSD. Conclusions NFATcl is associated with the occurrence of VSD and it may be a predisposing gene to CHD in Hart Chinese. This finding has set a direction for further genetic and functional studies.展开更多
文摘CBSD(Component Based Software Development)在嵌入式开发领域正逐步得到应用,软件构件的非功能属性(Non-FunctionalAttribute,NFA)对开发成功与否至关重要。现有的模型专注于构件复用框架的建立,通过建立一些框架模型进行定性的描述,缺乏量化的评定。该文通过建立一个层次分析模型,对影响嵌入式软件构件的NFA的各种不可度量的模糊描述,细分为每一个都可以进行测量的子属性,根据考察构件所应用领域的侧重点不同,赋予不同属性不同的影响权系数,进而计算出一个描述NFA的数值,在实际工程中可以作为构件NFA的考察指标。
基金This work was supported by a grant from the National Natural Science Foundation of China （No. 30872701）.
文摘Background Congenital heart disease （CHD） is a diverse group of diseases determined by genetic and environmental factors. Considerable research has been done on genes associated with the development of the heart. Recently, focus is on the role of transcription factor NFATcl in the development of proper valve and septa. As part of a larger study, high density single nucleotide polymorphism （SNP） scanning was used to explore the relationship between NFATcl gene polymorphism and susceptibility to ventricular septal defect （VSD） in the Chinese Hart population. Methods One hundred and ninety-two pediatric patients with congenital VSD and 192 matching healthy control subjects were studied. The haplotype reconstructions were calculated by PHASE2.0 software. Haploview software was used to perform linkage disequilibrium assessment and define haplotype blocks. The algorithm used for defining the blocks was the confidence interval method. Results The NFATcl gene region can be divided into 11 haplotype blocks. Strong linkage disequilibrium existed within blocks 6, 8, 9, and 11. Three SNPs （rs7240256, rs11665469, and rs754505） within the NFATcl gene had significant correlation with VSD by single marker association analysis. In addition, two haplotypes correlated with VSD. Conclusions NFATcl is associated with the occurrence of VSD and it may be a predisposing gene to CHD in Hart Chinese. This finding has set a direction for further genetic and functional studies.
