Information was obtained from the same questionnaire (23 risk factors listed) of cases and controls. We used a multivariate logistic model, which described variables significantly increased risk of birth defects....Information was obtained from the same questionnaire (23 risk factors listed) of cases and controls. We used a multivariate logistic model, which described variables significantly increased risk of birth defects. The risk factors included maternal educational levels, medicine taken during pregnancy and antenatal care. It was suggested to strengthen antenatal care was the main preventive measure against birth defects.展开更多
Mine accidents and injuries are complex and generally characterized by several factors starting from personal to technical, and technical to social characteristics.In this study, an attempt has been made to identify t...Mine accidents and injuries are complex and generally characterized by several factors starting from personal to technical, and technical to social characteristics.In this study, an attempt has been made to identify the various factors responsible for work related injuries in mines and to estimate the risk of work injury to mine workers.The prediction of work injury in mines was done by a step-by-step multivariate logistic regression modeling with an application to case study mines in India.In total, 18 variables were considered in this study.Most of the variables are not directly quantifiable.Instruments were developed to quantify them through a questionnaire type survey.Underground mine workers were randomly selected for the survey.Responses from 300 participants were used for the analysis.Four variables, age, negative affectivity, job dissatisfaction, and physical hazards, bear significant discriminating power for risk of injury to the workers, comparing between cases and controls in a multivariate situation while controlling all the personal and socio-technical variables.The analysis reveals that negatively affected workers are 2.54 times more prone to injuries than the less negatively affected workers and this factor is a more important risk factor for the case-study mines.Long term planning through identification of the negative individuals, proper counseling regarding the adverse effects of negative behaviors and special training is urgently required.Care should be taken for the aged and experienced workers in terms of their job responsibility and training requirements.Management should provide a friendly atmosphere during work to increase the confidence of the injury prone miners.展开更多
Background: Binary as well as polytomous logistic models are widely used for estimating odds ratios when the exposure of prime interest assumes unordered multiple levels under matched pairs case-control design. In our...Background: Binary as well as polytomous logistic models are widely used for estimating odds ratios when the exposure of prime interest assumes unordered multiple levels under matched pairs case-control design. In our previous studies, we have shown that the use of a polytomous logistic model for estimating cumulative odds ratios when the outcome (response) variable is ordinal (in addition to being polytomous) under matched pairs case-control design. The cumulative odds ratios were estimated based on separate fitting of the model at each of the cutpoint level as compared to less than equal to that level. In this paper we propose an alternative method of estimating the cumulative odds ratios and reanalyze the Los Angeles Endometrial Cancer data in the context of dose levels of conjugated oestrogen exposure and development of endometrial cancer under the matched pair case-control design. Methods: In the present study, the cumulative logit model is fitted using a single multinomial logit model for the data. For this, the full maximum likelihood estimation procedure is adopted. A test for equality of the cumulative odds ratios across the exposure levels is proposed. Results: The analysis revealed that there is a strong evidence of risk for developing endometrial cancer due to oestrogen exposure above each of the three dose level as compared to less than equal to that level. The estimated values at the three cutpoint levels were found to be 6.17, 3.60 and 5.16 respectively. Conclusions: The odds of developing endometrial cancer are very high for the users of any amount of oestrogen, even if it is the least dose, as compared to the non-users.展开更多
文摘Information was obtained from the same questionnaire (23 risk factors listed) of cases and controls. We used a multivariate logistic model, which described variables significantly increased risk of birth defects. The risk factors included maternal educational levels, medicine taken during pregnancy and antenatal care. It was suggested to strengthen antenatal care was the main preventive measure against birth defects.
文摘Mine accidents and injuries are complex and generally characterized by several factors starting from personal to technical, and technical to social characteristics.In this study, an attempt has been made to identify the various factors responsible for work related injuries in mines and to estimate the risk of work injury to mine workers.The prediction of work injury in mines was done by a step-by-step multivariate logistic regression modeling with an application to case study mines in India.In total, 18 variables were considered in this study.Most of the variables are not directly quantifiable.Instruments were developed to quantify them through a questionnaire type survey.Underground mine workers were randomly selected for the survey.Responses from 300 participants were used for the analysis.Four variables, age, negative affectivity, job dissatisfaction, and physical hazards, bear significant discriminating power for risk of injury to the workers, comparing between cases and controls in a multivariate situation while controlling all the personal and socio-technical variables.The analysis reveals that negatively affected workers are 2.54 times more prone to injuries than the less negatively affected workers and this factor is a more important risk factor for the case-study mines.Long term planning through identification of the negative individuals, proper counseling regarding the adverse effects of negative behaviors and special training is urgently required.Care should be taken for the aged and experienced workers in terms of their job responsibility and training requirements.Management should provide a friendly atmosphere during work to increase the confidence of the injury prone miners.
文摘Background: Binary as well as polytomous logistic models are widely used for estimating odds ratios when the exposure of prime interest assumes unordered multiple levels under matched pairs case-control design. In our previous studies, we have shown that the use of a polytomous logistic model for estimating cumulative odds ratios when the outcome (response) variable is ordinal (in addition to being polytomous) under matched pairs case-control design. The cumulative odds ratios were estimated based on separate fitting of the model at each of the cutpoint level as compared to less than equal to that level. In this paper we propose an alternative method of estimating the cumulative odds ratios and reanalyze the Los Angeles Endometrial Cancer data in the context of dose levels of conjugated oestrogen exposure and development of endometrial cancer under the matched pair case-control design. Methods: In the present study, the cumulative logit model is fitted using a single multinomial logit model for the data. For this, the full maximum likelihood estimation procedure is adopted. A test for equality of the cumulative odds ratios across the exposure levels is proposed. Results: The analysis revealed that there is a strong evidence of risk for developing endometrial cancer due to oestrogen exposure above each of the three dose level as compared to less than equal to that level. The estimated values at the three cutpoint levels were found to be 6.17, 3.60 and 5.16 respectively. Conclusions: The odds of developing endometrial cancer are very high for the users of any amount of oestrogen, even if it is the least dose, as compared to the non-users.
