Exploring the therapeutic potential of Qi Teng Mai Ning recipe in ischemic stroke and vascular cognitive impairment

Background:This study aims to explore the therapeutic effects of the Qi Teng Mai Ning recipe on ischemic stroke and vascular cognitive impairment through its potential to modulate cellular autophagy,with a focus on identifying its active ingredients and their target proteins.Methods:The study began with the identification of active ingredients in the Qi Teng Mai Ning recipe.It proceeded to screen the gene expression omnibus database for ischemic stroke and vascular cognitive impairment-associated differentially expressed mRNAs and to identify cellular autophagy-related proteins via the Human Autophagy Database.These proteins were annotated with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functions and subjected to molecular docking with the recipe’s core active ingredients.In vitro cell experiments were conducted on hypoxic HT22 cells,involving CCK8 assay,lentiviral transfection to silence autophagy related 9B(ATG9B),immunofluorescence staining,and qPCR validation to investigate the effects of the recipe on autophagy.Results:The analysis identified 104 active ingredients targeting 408 proteins and forming a complex ingredient-target network.Intersecting 55 ischemic stroke-related and 909 vascular cognitive impairment-related differentially expressed mRNAs revealed 14 co-expressed mRNAs.Molecular docking showed quercetin,kaempferol,myrcene,and conferone as key ingredients targeting autophagy-related proteins.Cellular experiments indicated that the recipe significantly enhanced cell viability under hypoxic conditions,reduced apoptosis,and modulated the expression of autophagy-related factors,thereby decreasing apoptosis rates in HT22 cells.Conclusion:The Qi Teng Mai Ning recipe offers protective effects against ischemic stroke and vascular cognitive impairment by modulating autophagy-related proteins.Its efficacy highlights the potential of traditional Chinese medicine in treating these conditions,though further research is needed to fully understand its mechanisms and clinical applications.

Analyzing Thermal Stratification and Nanoparticle Shapes Influence on an EMHD Ternary Nanofluid Flow amidst Two Spinning Disks

The present study examines the thermal distribution of ternary nanofluid flow amid two spinning disks influenced by electric and magnetic fields. Keeping in view the shape of the particles, the electrically conducting ternary nanofluid is analyzed with variable thermophysical features. Three types of nanoparticles namely Copper, Aluminum Oxide, and Graphene with spherical, cylindrical, and platelet shapes are taken respectively and are immersed in a (50-50)% ratio of water and ethylene glycol mixture which acts as a base fluid. The anticipated problem is addressed by employing a reliable and user-friendly numerical bvp4c built-in collocation scheme. This solution is then showcased through illustrations and tables. Strengthening the radiation results in an enhanced heat transfer rate. Radial and azimuthal velocities once rotation of disks is enhanced. The key findings provide a strong theoretical background in photovoltaic cells, solar collectors, radiators, solar water heaters, and many other applications.

SOME ALGORITHMS FOR NC MACHINING SIMULATION AND VERIFICATION

This paper presents an approximation method to display realistic pictures of numerical control (NC) machining simulation very quickly. T he tool movement envelope is divided into many small regions and the normal to t hese small regions is calculated. The system saves the calculated result in a fi le before starting animation display. When the system starts displaying machinin g animation, it does not need to calculate small triangular facets normal to the workpiece surface. It only needs to find out what part of the cutter cuts the w orkpiece surface and to read the normal from the file. A highly efficient NC cod e verification method is also presented in this paper. The method first detects the error in z direction. If some points are reported to be out of the tolerance , the system divides neighborhood of these points into smaller grids and calcula tes the normal surface at each grid intersection and the error in the normal ve ctor direction.

基于GA-Q-learning算法的虚拟维修作业规划模型

针对虚拟维修环境中任务执行过程存在的不确定性和随机性问题,提出了一种基于Q学习算法的作业策略规划模型,该方法将虚拟维修过程转化为选取不同动作参与状态转移的过程。在该过程中,采用试错机制和逆向求解的方法求解动作策略规划问题,并将任务特征匹配机制和顺序约束机制作为启发机制,保证策略学习过程中持续进化可行策略;在进化过程中,将动作因子赋予概率值,并采用遗传算法(GA)进化动作因子的概率分布,避免了策略学习过程中强化早期Q值较高的动作,为求解虚拟维修的最佳作业流程提供了一种行之有效的解决方法。将该方法应用于轮式挖掘机虚拟维修训练系统中,仿真结果表明,正确的动作在作业策略迭代过程中均能够获得较高的Q值,验证了方法的可行性和实用性。

大电流密度放电中钾的Penning电离观测

本文叙述了自制的大电流密度、快脉冲放电电源，及用该放电装置激励Ｈｅ／Ｋ混合蒸气，观测到Ｈｅ／Ｋ间能量传递产生的钾的Ｐｅｎｎｉｎｇ电离。

Influence of confi ning pressure and impact loading on mechanical properties of amphibolite and sericite-quartz schist

In order to investigate the dynamic mechanical properties of amphibolite and sericite-quartz schist under confi ning pressure, two rocks are subjected to impact loadings with different strain rates and confi ning pressures by using split Hopkinson pressure bar equipment with a confi ning pressure device. Based on the experimental results, the stress-strain curves are analyzed and the effects of confi ning pressure and strain rates on the dynamic compressive strength, peak strain and failure mode are summarized. The results show that:(1) The characteristics of two rocks in the ascent stage of the stressstrain curve are basically the same, but in the descent stage, the rocks gradually show plastic deformation characteristics as the confi ning pressure increases.(2) The dynamic compressive strength and peak strain of two rocks increase as the strain rate increases and the confi ning pressure effects are obvious.(3) Due to the effect of confi ning pressure, the normal stress on the damage surface of the rock increases correspondingly, the bearing capacity of the crack friction exceeds the material cohesion and the slippage of the fractured rock is controlled, which all lead to the compression and shear failure mode of rock. The theoretical analysis and experimental methods to study the dynamic failure mode and other related characteristics of rock are useful in developing standards for engineering practice.

Properties of a new type Al/Pb-0.3%Ag alloy composite anode for zinc electrowinning

An A1/Pb-0.3%Ag alloy composite anode was produced via composite casting. Its electrocatalytic activity for the oxygen evolution reaction and corrosion resistance was evaluated by anodic polarization curves and accelerated corro- sion test, respectively. The microscopic morphologies of the anode section and anodic oxidation layer during accelerated corrosion test were obtained by scanning electron microscopy. It is found that the composite anode （hard anodizing） dis- plays a more compact interracial combination and a better adhesive strength than plating tin. Compared with industrial Pb-0.3%Ag anodes, the oxygen evolution overpotentials of A1/Pb-0.3%Ag alloy （hard anodizing） and A1/Pb-0.3%Ag alloy （plating tin） at 500 A.m-2 were lower by 57 and 14 mV, respectively. Furthermore, the corrosion rates of Pb-0.3%Ag alloy, A1/Pb-0.3%Ag alloy （hard anodizing）, and A1/Pb-0.3%Ag alloy （plating tin） were 13.977, 9.487, and 11.824 g.m-2.h-1, respectively, in accelerated corrosion test for 8 h at 2000 A-m-2. The anodic oxidation layer of A1/Pb-0.3%Ag alloy （hard anodizing） is more compact than Pb-0.3%Ag alloy and A1/Pb-0.3%Ag alloy （plating tin） after the test.

Water Extraction Process of Chinese Herbal Compound Man Gan Ning

[Objectives]To optimize the water extraction process of Chinese Herbal Compound Man Gan Ning and establish a method for its extraction and content determination.[Methods]The L9(34)orthogonal test was carried out,the comprehensive scores of ginsenoside Rb1 content,notoginsenoside R1 content,tanshinone I content and saikosaponin A content in the compound extract were used as evaluation indicators to explore the effects of water addition,the water addition,decoction time and decoction times on the water extraction process,and verification tests were carried out.[Results]The optimized water extraction process was as follows:adding 9 times of water in the first extraction,and extracting for 90 min;adding 7 times of water in the second extraction,and extracting for 60 min;adding 7 times of water in the third extraction,and extracting for 60 min.[Conclusions]The optimized water extraction process is stable and feasible,and can be used for the extraction of various herbs in Compound Man Gan Ning.It can also provide experimental basis for the formulation development of Compound Man Gan Ning sustained release tablet.

The Lost-Wax Process in the Pre-Qin Period: A Bronze Appendage with Hollow Snake Patterns from the Tomb of Duke Ning of Xu

This paper discusses the most recent case of the lost-wax process,namely,a bronze appendage with hollow snake patterns excavated in 2002 at the tomb of Duke Ning of Xu(許公寧)(a state in the Spring and Autumn period)in Ye County,Henan Province.Various physical and chemical analyses indicate that this artifact was cast as a whole in 547 BCE or slightly later in a high tin bronze alloy using the lost-wax process.No traces of cast joints or soldering were found.This research provides further proof that the lost-wax process was a significant technical development achieved by casters in the Pre-Qin period.

Jian Nao Ning for Treatment of Memory Impairment in Patients with Mild or Moderate Multi-infarct Dementia

Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at baseline and endpoint using memory subscales of a battery of New Psychometric Tests (Chinese version) including mini-mental state examination (MMSE), verbal memory, and non-verbal memory, etc. After treatment, the mean scores of verbal memory in the Hopkins Verbal Learning Test (P<0.05) and total memory scores of memory items (P<0.001) in JNN group increased significantly; and improvement in episodic memory function including story recall (immediate and delayed), delayed word recall, verbal learning and verbal recognition and visual recognition in the JNN group was better than that in the duxil control group, suggesting that JNN can obviously improve memory function for the patients with mild or moderate multi-infarct dementia.

Research on the Accurate Location of the 2007 M_S6.4 Ning'er, Yunnan Earthquake

Five mobile digital seismic stations were set up by the Earthquake Administration of Yunnan Province near the epicenter of the main shock after the Ning＇er M6. 4 earthquake on June 3, 2007. In this paper, the aftershock sequence of the Ning＇er M6. 4 earthquake is relocated by using the double difference earthquake location method. The data is from the 5 mobile digital seismic stations and the permanent Simao seismic station. The results show that the length of the aftershock sequence is 40kin and the width is 30km, concentrated obviously at the lateral displacement area between the Pu＇er fault and the NNE-trending faults, with the majority occurring on the Pu＇er fault around the main shock. The depths of aftershocks are from 2kin to 12km, and the predominant distribution is in the depth of 8 ~ 10km. The mean depth is 7. 9kin. The seismic fault dips to the northwest revealed from the profile parallel to this aftershock sequence, which is identical to the dip of the secondary fault of the NE-trending Menglian-Mojiang fault in the earthquake area. There are more earthquakes concentrated in the northwest segment than in the southeast segment, which is perhaps related to the underground medium and faults. The depth profile of the earthquake sequence shows that the relocated earthquakes are mainly located near the Pu＇er fault and the seismic faults dip to the southwest, consistent with the dip of the west branch of the Pu＇er fault. In all, the fault strike revealed by earthquake relocations matches well with the strike in the focal mechanism solutions. The main shock is in the top of the aftershock sequence and the aftershocks are symmetrically distributed, showing that faulting was complete in both the NE and SW directions.

血栓心脉宁片通过调控TGF-β_(1)和Runx2表达抑制血管平滑肌细胞钙化的研究

目的探讨血栓心脉宁片是否可通过调控转化生长因子β_(1)(TGF-β_(1))和Runt相关转录因子2(Runx2)表达抑制血管平滑肌细胞的钙化。方法取对数生长期大鼠血管平滑肌细胞,实验分为5组:阴性组细胞加入DMEM培养液培养;钙化组加入β-磷酸甘油(β-GP)作用24 h诱导血管平滑肌细胞钙化;血栓心脉宁低、中、高剂量组先分别加入125 mg/L、250 mg/L、500 mg/L的血栓心脉宁片培养24 h后再给予β-GP作用24 h。采用CCK-8法检测各组细胞活力,酶标仪检测各组细胞中钙含量、碱性磷酸酶(ALP)活性及TGF-β_(1)含量,Western blot法检测细胞中Runx2蛋白表达情况。结果与阴性组比较,钙化组细胞活力明显下降(P<0.05),细胞中钙含量、ALP活性、TGF-β_(1)含量及Runx2蛋白相对表达量均明显升高(P均<0.05);与钙化组比较,血栓心脉宁各组细胞活力均明显提高(P均<0.05),细胞中钙含量、ALP活性、TGF-β_(1)含量及Runx2蛋白相对表达量均明显降低(P均<0.05),且各指标均呈浓度依赖性变化。结论血栓心脉宁片可能通过调控TGF-β_(1)和Runx2的表达,抑制大鼠血管平滑肌细胞的钙化。

Pinning sampled-data synchronization for complex networks with probabilistic coupling delay

We deal with the problem of pinning sampled-data synchronization for a complex network with probabilistic time-varying coupling delay. The sampling period considered here is assumed to be less than a given bound. Without using the Kronecker product, a new synchronization error system is constructed by using the property of the random variable and input delay approach. Based on the Lyapunov theory, a delay-dependent pinning sampled-data synchronization criterion is derived in terms of linear matrix inequalities （LMIs） that can be solved effectively by using MATLAB LMI toolbox. Numerical examples are provided to demonstrate the effectiveness of the proposed scheme.

Ning Yuhua:An Expert on Wheat Breeding

ＮｉｎｇＹｕｈｕａ：ＡｎＥｘｐｅｒｔｏｎＷｈｅａｔＢｒｅｅｄｉｎｇＤｅｖｏｔｅｄｂｏｔｈｔｏｗｈｅａｔａｎｄｔｏｔｈｅｆａｒｍｅｒｓｗｈｏｇｒｏｗｉｔ，ａｎａｇｒｉｃｕｔｕｒｉｓｔｍａｋｅｓｇｒｅａｔｃｏｎｔｒｉｂｕｔｉｏｎｓ．ＰｒｏｆｅｓｓｏｒＮｉ...

ETUDE DE ENCEPHALE ATLAS DANSPRE - TRAITEMENT ET POST - TRAITEMENT DE MALADIE CEREBROVASCULAIRE ISCHEMIQUE PAR "PIAN TAN NING

为了进行国际交流,本刊除刊登一些英文稿件外,从本期开始也将刊登些其他外文稿件,如法文或日文稿等。本期刊登一篇法文稿,供大家参考。

从多音字“宁”姓氏用法的收录谈规范型工具书与语言规范

工具书中多音字姓氏用法的收录,一直是广大读者非常关注的问题,也是辞书编纂修订工作的难点之一。“宁”是现代常见的姓氏,由于“宁”是多音字,有níng和nìng两个声调不同的读音,并且与姓氏用字“甯nìng”存在比较复杂的关系,目前常见的工具书,包括专门的姓氏辞典,在收录“宁níng”“宁nìng”“甯nìng”姓氏时存在分歧,有的工具书前后版本对“宁”作为姓氏的收录也有调整。本文梳理目前常见工具书的收录情况,从“寜”“甯”“宁”的历史渊源、相关语言规范和应用实际等方面分析收录差异,进而阐述了现代汉语规范型工具书如何落实语言规范、反哺规范的问题。

STUDY AND PREPARATION ON "PAIN TAN NING" AND ITS CLINICAL APPLICATION AND STUDY ON BRAIN ATLAS

Objective: To observe clinical effect of combined mixture of traditional chineses and western medicine "PIAN TAN NING" in treatment of ischemic cerebrovascular diseases and change of brain atlas. Methods:In 6660 patients with ischemic cerebrovascular disease, the curative effect of "PIAN TAN NING" and brain atlas were observed and other 30 cases were compared with treatment of Dextran. Results:After treatment, patient's clinical symptoms and recovered degree of myodynamia and brain atlas improved significantly. Total effective rate was 96. 7%. But the contral group was 80. 0%. There was a significant difference between them ( p ＜ 0. 05 ). Conclusion: The "PIAN TAN NING" produced a good clinical curative effect in treatment of ischemic cerebrovascular diseases and the side effect was only a few. So it can be applied very well in patients with ischemic cerebrovascular disease. The applied value of brain atlas was very good.