Objective The Yanshan Fold Belt is located within the northern margin of the North China platform and contains welldeveloped and widespread Neoproterozoic and Mesoproterozoic sedimentary units with a total thickness o...Objective The Yanshan Fold Belt is located within the northern margin of the North China platform and contains welldeveloped and widespread Neoproterozoic and Mesoproterozoic sedimentary units with a total thickness of up to 9000 m.Previous studies identified many oil seedlings as well as asphalt and ancient hydrocarbon reservoirs in Northern Hebei depression and western Liaoning depression.This research indicates that the Mesoproterozoic and Neoproterozoic sedimentary units are ideally suited for the formation of significant oil and gas resources.The Niu D1 well was drilled by the China Geological Survey(CGS)in the Niuyingzi area and intercepted oil immersions and oil-and gas-bearing units within a limestone reservoir in the middle Proterozoic Gaoyuzhuang Formation(Fig.1).This study presents new biomarker compound and carbon isotope data that indicate that the oil within this formation was derived from hydrocarbon source rocks of the Hongshuizhuang Formation,part of the Mesoproterozoic Jixian Series,and the reservoir type is overthrust fault fractured anticline hydrocarbon reservoir.The oil reservoir within the Gaoyuzhuang Formation limestone might represent the oldest oil reservoir discovered to date within the Yanliao faulted depression zone.展开更多
Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(...Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(TCM) has its unique advantage in targeting multiple signaling pathways with multiple components. Many TCM formulas have the potential for neuroprotection and neurogenesis, but well-designed clinical trials are insufficient and underlying mechanisms unclear. Herein, we introduce the commonly used TCM formulas for stroke treatment and selectively introduce two classic formulas, An Gong Niu Huang(AGNH) pill and Bu Yang Huan Wu Decoction(BYHWD) for neuroprotection and neurogenesis, respectively. Current scientific evidence and clinical trials indicate AGNH pill could be an effective neuroprotective formula as adjunct therapy with relative safety. On the other hand, as a representative TCM formula for post stroke disability, BYHWD could improve the neurological outcome with its neuroprotective and neurogenic effects. The underlying mechanisms could be attributed to the modulation of multiple molecular targets with its multiple components. In conclusion, TCM formulas could be potential adjunct therapies for stroke treatment. The clinical efficacies and molecular mechanisms of promoting neuroprotection and neurogenesis remain to be further studies.展开更多
The yield and stereoselectivity of the Diels-Alder reactions between furan(or 2-methylfuran)and different dienophiles are markedly enhanced by the catalysis of anhydrous YbCl_3.
The Mac-Millan's equation for the non-linear non-holongmic system in one order is derived by using only principle of differential variation of Jourdain. Therefore definition of Niu Qinping for the virtual displace...The Mac-Millan's equation for the non-linear non-holongmic system in one order is derived by using only principle of differential variation of Jourdain. Therefore definition of Niu Qinping for the virtual displacentent is unnecessary. This is the natural deduetion of the method in this paper and so with the non-linear and non holonomic system in high order.展开更多
According to the Chinese lunar cal-endar, every year corresponds to an animal, and there are 12 animals-rat, ox, tiger, rabbit, dragon, snake, horse, sheep, monkey, rooster,
"My father established our company 22 years ago. For me, a 29-year-old woman, the company is like my younger brother," says Niu Ruiyi, managing director of Herbal Heaven Cultural Ornaments Co., Ltd., an ente..."My father established our company 22 years ago. For me, a 29-year-old woman, the company is like my younger brother," says Niu Ruiyi, managing director of Herbal Heaven Cultural Ornaments Co., Ltd., an enterprise dedicated to designing, producing and selling leather products in Shijiazhuang, capital of North China's Hebei Province.展开更多
基金funded by the China Geological Survey Project(Grant No.DD20190098).
文摘Objective The Yanshan Fold Belt is located within the northern margin of the North China platform and contains welldeveloped and widespread Neoproterozoic and Mesoproterozoic sedimentary units with a total thickness of up to 9000 m.Previous studies identified many oil seedlings as well as asphalt and ancient hydrocarbon reservoirs in Northern Hebei depression and western Liaoning depression.This research indicates that the Mesoproterozoic and Neoproterozoic sedimentary units are ideally suited for the formation of significant oil and gas resources.The Niu D1 well was drilled by the China Geological Survey(CGS)in the Niuyingzi area and intercepted oil immersions and oil-and gas-bearing units within a limestone reservoir in the middle Proterozoic Gaoyuzhuang Formation(Fig.1).This study presents new biomarker compound and carbon isotope data that indicate that the oil within this formation was derived from hydrocarbon source rocks of the Hongshuizhuang Formation,part of the Mesoproterozoic Jixian Series,and the reservoir type is overthrust fault fractured anticline hydrocarbon reservoir.The oil reservoir within the Gaoyuzhuang Formation limestone might represent the oldest oil reservoir discovered to date within the Yanliao faulted depression zone.
基金funding support from the Hong Kong Innovation and Technology Commission ITF grant (UIM/289)Grant from National Natural Science Foundation of China (No. 31570855)Contract Research Project of Beijing Tong Ren Tang Chinese Medicine Co. Ltd.
文摘Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(TCM) has its unique advantage in targeting multiple signaling pathways with multiple components. Many TCM formulas have the potential for neuroprotection and neurogenesis, but well-designed clinical trials are insufficient and underlying mechanisms unclear. Herein, we introduce the commonly used TCM formulas for stroke treatment and selectively introduce two classic formulas, An Gong Niu Huang(AGNH) pill and Bu Yang Huan Wu Decoction(BYHWD) for neuroprotection and neurogenesis, respectively. Current scientific evidence and clinical trials indicate AGNH pill could be an effective neuroprotective formula as adjunct therapy with relative safety. On the other hand, as a representative TCM formula for post stroke disability, BYHWD could improve the neurological outcome with its neuroprotective and neurogenic effects. The underlying mechanisms could be attributed to the modulation of multiple molecular targets with its multiple components. In conclusion, TCM formulas could be potential adjunct therapies for stroke treatment. The clinical efficacies and molecular mechanisms of promoting neuroprotection and neurogenesis remain to be further studies.
文摘The yield and stereoselectivity of the Diels-Alder reactions between furan(or 2-methylfuran)and different dienophiles are markedly enhanced by the catalysis of anhydrous YbCl_3.
文摘The Mac-Millan's equation for the non-linear non-holongmic system in one order is derived by using only principle of differential variation of Jourdain. Therefore definition of Niu Qinping for the virtual displacentent is unnecessary. This is the natural deduetion of the method in this paper and so with the non-linear and non holonomic system in high order.
文摘According to the Chinese lunar cal-endar, every year corresponds to an animal, and there are 12 animals-rat, ox, tiger, rabbit, dragon, snake, horse, sheep, monkey, rooster,
文摘"My father established our company 22 years ago. For me, a 29-year-old woman, the company is like my younger brother," says Niu Ruiyi, managing director of Herbal Heaven Cultural Ornaments Co., Ltd., an enterprise dedicated to designing, producing and selling leather products in Shijiazhuang, capital of North China's Hebei Province.
