Background and Objective:Expression of Skp2 was related with the prognosis of several tumors.However,there was no intensive study on the relationship between Skp2 and extranodal NK/T-cell lymphoma.This study was to ex...Background and Objective:Expression of Skp2 was related with the prognosis of several tumors.However,there was no intensive study on the relationship between Skp2 and extranodal NK/T-cell lymphoma.This study was to explore the role of Skp2 in extranodal NK/T-cell lymphoma.Methods:The clinicopathological data of 39 patients with extranodal NK/T-cell lymphoma were analyzed.The expression of Skp2 was examined by immunohistochemistry on formalin-fixed,paraffin-embedded tissue sections.Results:Among the patients with high expression of Skp2,complete remission(CR) rate was only 14.3%(2/14).However,CR rate among the patients with low expression of Skp2 was 68.0%(17/25).Significant difference was shown between these two groups(P < 0.001).In the group of low expression,the median overall survival(OS) was 85.59 months(95% CI:35.83-135.34 months),the 1-and 2-year OS rates were 81% and 71%,respectively.However,in the group of high expression,the median OS was only 9.73 months(95% CI:2.05-17.40 months),the 1-and 2-year OS rates were 42% and 14%,respectively.There was statistical difference between these two groups(P < 0.001).Multivariate analysis showed that Skp2 expression(P <0.001),LDH(P = 0.026) and ECOG PS(P = 0.003) were dependent prognostic factors of extranodal NK/T-cell lymphoma.Conclusion:High expression of Skp2 is an independent unfavorite adverse prognostic factor of extranodal NK/T-cell lymphoma.展开更多
目的:探讨治疗前淋巴细胞与C反应蛋白比值(LCR)对结外NK/T细胞淋巴瘤(ENKTL)预后的判断价值。方法:回顾性分析郑州大学第一附属医院收治的203例初诊为ENKTL患者的临床资料,ROC曲线得到LCR预测5 a总生存期(OS)的最佳截断值,并根据截断值...目的:探讨治疗前淋巴细胞与C反应蛋白比值(LCR)对结外NK/T细胞淋巴瘤(ENKTL)预后的判断价值。方法:回顾性分析郑州大学第一附属医院收治的203例初诊为ENKTL患者的临床资料,ROC曲线得到LCR预测5 a总生存期(OS)的最佳截断值,并根据截断值将患者分为两组,绘制Kaplan-Meier生存曲线,采用Cox回归分析无进展生存期(PFS)和OS的影响因素。结果:LCR预测5 a OS的最佳截断值为0.19,低LCR组患者预后较差(P<0.001)。Cox回归分析结果表明,低LCR组ENKTL患者预后较差,PFS和OS的HR(95%CI)分别为0.462(0.336~0.636)和0.381(0.275~0.527)。结论:治疗前LCR可影响ENKTL预后,低LCR患者的预后较差。展开更多
基金Natural Science Foundation of Guangdong Province (No 05200178)Projects under Scientific and Technological Planning of Guangzhou City (No2006Z3-E0021)
文摘Background and Objective:Expression of Skp2 was related with the prognosis of several tumors.However,there was no intensive study on the relationship between Skp2 and extranodal NK/T-cell lymphoma.This study was to explore the role of Skp2 in extranodal NK/T-cell lymphoma.Methods:The clinicopathological data of 39 patients with extranodal NK/T-cell lymphoma were analyzed.The expression of Skp2 was examined by immunohistochemistry on formalin-fixed,paraffin-embedded tissue sections.Results:Among the patients with high expression of Skp2,complete remission(CR) rate was only 14.3%(2/14).However,CR rate among the patients with low expression of Skp2 was 68.0%(17/25).Significant difference was shown between these two groups(P < 0.001).In the group of low expression,the median overall survival(OS) was 85.59 months(95% CI:35.83-135.34 months),the 1-and 2-year OS rates were 81% and 71%,respectively.However,in the group of high expression,the median OS was only 9.73 months(95% CI:2.05-17.40 months),the 1-and 2-year OS rates were 42% and 14%,respectively.There was statistical difference between these two groups(P < 0.001).Multivariate analysis showed that Skp2 expression(P <0.001),LDH(P = 0.026) and ECOG PS(P = 0.003) were dependent prognostic factors of extranodal NK/T-cell lymphoma.Conclusion:High expression of Skp2 is an independent unfavorite adverse prognostic factor of extranodal NK/T-cell lymphoma.
文摘目的:探讨治疗前淋巴细胞与C反应蛋白比值(LCR)对结外NK/T细胞淋巴瘤(ENKTL)预后的判断价值。方法:回顾性分析郑州大学第一附属医院收治的203例初诊为ENKTL患者的临床资料,ROC曲线得到LCR预测5 a总生存期(OS)的最佳截断值,并根据截断值将患者分为两组,绘制Kaplan-Meier生存曲线,采用Cox回归分析无进展生存期(PFS)和OS的影响因素。结果:LCR预测5 a OS的最佳截断值为0.19,低LCR组患者预后较差(P<0.001)。Cox回归分析结果表明,低LCR组ENKTL患者预后较差,PFS和OS的HR(95%CI)分别为0.462(0.336~0.636)和0.381(0.275~0.527)。结论:治疗前LCR可影响ENKTL预后,低LCR患者的预后较差。
