Kadsura belongs to the Schisandroideae subfamily of Magnoliaceae.Plants from genus Kadsura are widely distributed in the South and Southwest of China.The plants of the genus are widely used as folk medicine for a long...Kadsura belongs to the Schisandroideae subfamily of Magnoliaceae.Plants from genus Kadsura are widely distributed in the South and Southwest of China.The plants of the genus are widely used as folk medicine for a long time in history,with the functions of relieving pain,promoting 'qi' circulation,activating blood resolve stasis,and applications in the treatment of rheumatoid arthritis and gastroenteric disorders.Lignans are the primary characteristic constituents with various biological activities of plants from genus Kadsura.This paper summarized 81 lignans isolated from the plants of genus Kadsura over the past eight years(from 2014 to 2021),which belong to five types:dibenzocyclooctadienes,spirobenzofuranoid dibenzocyclooctadienes,aryltetralins,diarylbutanes and tetrahydrofurans.Each type of these lignans possess typical characteristics in proton magnetic resonance(^(1)H NMR) and carbon-13 nuclear magnetic resonance(^(13)C NMR) spectra,the NMR regularities of these types of lingans were summarized,which provided a useful reference for the structural analysis of lignans.The relationships between lignans and pharmacodynamics were also systematically analyzed,lignans were predicted to be the quality markers(Q-marker) of Kadsura genus.展开更多
The binding reaction between 10-hydroxycamptothecin (10-HCPT) and human serum albumins (HSA) is studied by means of fluorescence spectroscopy, UV-Vis absorption spectrum, IH NMR spectrum, and molecular simulation....The binding reaction between 10-hydroxycamptothecin (10-HCPT) and human serum albumins (HSA) is studied by means of fluorescence spectroscopy, UV-Vis absorption spectrum, IH NMR spectrum, and molecular simulation. The results indicate that the binding reaction of 10-HCPT and HSA is a single static quenching process, and the binding equilibrium constant for 10-HCPT binding with HSA is estimated K0-4.93×10^4 L · mol-I at 25 ℃ with the molar ratio of I : 1. The distance (r) and energy transfer efficiency(E) between donor (HSA) and acceptor (10-HCPT) are obtained as follows, r=3.51 nm; E-0.27. The enthalpy change (△Hφ) and entropy change (△Sφ) are calcu- lated at different temperatures, and the hydrophobic force and shidipole force are the functions in the reaction. The results show that 10-HCPT binds within the subdomain II A of HSA by the hydrophobic force, and the 10-OH and 20-OH of 10-HCPT bind with both residue Leu-238 of HSA and Ala 291 of HSA by hydrogen bonds.展开更多
基金financially supported by the National Natural Science Foundation of China (No.81703819, 81874369 and 82074122)Natural Science Foundation of Hunan Province (No.2020JJ4463 and 2020JJ4064)。
文摘Kadsura belongs to the Schisandroideae subfamily of Magnoliaceae.Plants from genus Kadsura are widely distributed in the South and Southwest of China.The plants of the genus are widely used as folk medicine for a long time in history,with the functions of relieving pain,promoting 'qi' circulation,activating blood resolve stasis,and applications in the treatment of rheumatoid arthritis and gastroenteric disorders.Lignans are the primary characteristic constituents with various biological activities of plants from genus Kadsura.This paper summarized 81 lignans isolated from the plants of genus Kadsura over the past eight years(from 2014 to 2021),which belong to five types:dibenzocyclooctadienes,spirobenzofuranoid dibenzocyclooctadienes,aryltetralins,diarylbutanes and tetrahydrofurans.Each type of these lignans possess typical characteristics in proton magnetic resonance(^(1)H NMR) and carbon-13 nuclear magnetic resonance(^(13)C NMR) spectra,the NMR regularities of these types of lingans were summarized,which provided a useful reference for the structural analysis of lignans.The relationships between lignans and pharmacodynamics were also systematically analyzed,lignans were predicted to be the quality markers(Q-marker) of Kadsura genus.
基金Supported by the Foundation of Shandong Province Educa-tion Bureau (J06060)
文摘The binding reaction between 10-hydroxycamptothecin (10-HCPT) and human serum albumins (HSA) is studied by means of fluorescence spectroscopy, UV-Vis absorption spectrum, IH NMR spectrum, and molecular simulation. The results indicate that the binding reaction of 10-HCPT and HSA is a single static quenching process, and the binding equilibrium constant for 10-HCPT binding with HSA is estimated K0-4.93×10^4 L · mol-I at 25 ℃ with the molar ratio of I : 1. The distance (r) and energy transfer efficiency(E) between donor (HSA) and acceptor (10-HCPT) are obtained as follows, r=3.51 nm; E-0.27. The enthalpy change (△Hφ) and entropy change (△Sφ) are calcu- lated at different temperatures, and the hydrophobic force and shidipole force are the functions in the reaction. The results show that 10-HCPT binds within the subdomain II A of HSA by the hydrophobic force, and the 10-OH and 20-OH of 10-HCPT bind with both residue Leu-238 of HSA and Ala 291 of HSA by hydrogen bonds.