The interactions between four high bioactive diperoxovanadate complexes Kn[OV(O2)2L]mH2O (n = 1~3, m = 1~5, L = oxalate (abbr. oxa), picolinate (abbr. pic), bipyridine (abbr. bipy) and 1,10-phenanthroline (abbr. phen)...The interactions between four high bioactive diperoxovanadate complexes Kn[OV(O2)2L]mH2O (n = 1~3, m = 1~5, L = oxalate (abbr. oxa), picolinate (abbr. pic), bipyridine (abbr. bipy) and 1,10-phenanthroline (abbr. phen); their corresponding complexes abbreviated as bpV(oxa), bpV(pic), bpV(bipy) and bpV(phen), respectively) and imidazole (abbr. imi) in solution were studied by several NMR techniques: multinuclear (1H, 13C and 51V) and variable temperature 51V NMR. Competitive coordination interactions were observed and the order of the interaction strength of the four complexes with imidazole is as follows: bpV(oxa) > bpV(pic) > bpV(bipy) > bpV(phen), which is deeply affected by the identity of the ligands and has the same order as their inhibition effect toward bovine heart phosphotyrosyl protein phosphatase. The species [OV- (O2)2(imi)]- was formed in all cases. Both of the NMR data and equilibrium constants of the interaction systems were reported. The experimental results indicate that the species of bpV(oxa) and [OV(O2)2(imi)]- are six-coordinated, while bpV(pic), bpV(bipy) and bpV(phen) are seven- coordinated in solution. ESI-MS results support the conclusions obtained by NMR.展开更多
基金NNSFC (Nos. 10234070 and 10104011) NSF of Fujian Province (No. E0110003) and State Key Laboratory of Structural Chemistry (020058)
文摘The interactions between four high bioactive diperoxovanadate complexes Kn[OV(O2)2L]mH2O (n = 1~3, m = 1~5, L = oxalate (abbr. oxa), picolinate (abbr. pic), bipyridine (abbr. bipy) and 1,10-phenanthroline (abbr. phen); their corresponding complexes abbreviated as bpV(oxa), bpV(pic), bpV(bipy) and bpV(phen), respectively) and imidazole (abbr. imi) in solution were studied by several NMR techniques: multinuclear (1H, 13C and 51V) and variable temperature 51V NMR. Competitive coordination interactions were observed and the order of the interaction strength of the four complexes with imidazole is as follows: bpV(oxa) > bpV(pic) > bpV(bipy) > bpV(phen), which is deeply affected by the identity of the ligands and has the same order as their inhibition effect toward bovine heart phosphotyrosyl protein phosphatase. The species [OV- (O2)2(imi)]- was formed in all cases. Both of the NMR data and equilibrium constants of the interaction systems were reported. The experimental results indicate that the species of bpV(oxa) and [OV(O2)2(imi)]- are six-coordinated, while bpV(pic), bpV(bipy) and bpV(phen) are seven- coordinated in solution. ESI-MS results support the conclusions obtained by NMR.
基金supported by Key Project of Health and Science and Technology of Xiamen(3502Z20051027)Science Research Foundation of Ministry of Health & United Fujian Provincial Health and Education Project for Tackiling the Key Research ( WKJ2008-2-36)National Natu-ral Science Foundation of China (20803020)
