Structural Characterization and NO Generation Characteristics of Coal Char under O_(2)/CO_(2)Atmosphere

The evolution of pore structure and functional groups of coal char in different stages of Shenhua coal combustion process in O_(2)/CO_(2)atmosphere was studied by the low temperature nitrogen adsorption method,the scanning electron microscopy and the FTIR method.The relationship between the pore structure,oxygen-containing functional groups and NO generation characteristics of coal char under different inlet oxygen concentrations was analyzed.The result shows that the overall pore structure and shape of pulverized coal particles change continuously with the combustion;and the oxygen-containing functional groups on the surface of coal char indicate multi-peak changes and are related to NO generation.The oxygen concentration poses a larger impact on the change in coal particle size,oxygen-containing functional groups and NO generation;and there is an oxygen concentration that optimizes the reduction effect of the oxygen-containing functional group on NO.

Nitric oxide-generating self-assembling peptide hydrogel coating for enhancing hemocompatibility of blood-contacting devices

Thrombosis is the major stumbling block to the clinical application of blood-contacting devices.Herein,a quick and easy surface engineering strategy of hydrogel coating with the therapeutic gas nitric oxide(NO)generation was reported to realize up-regulation of cyclic guanosine monophosphate(c GMP)and improve hemocompatibility for diverse metal materials.We first introduce the active centre selenocysteine of glutathione peroxidase(GPx)to the self-assembling peptide(RADA)4,obtaining a functionalized hydrogel.Then the hydrogel is directly coated on the 316L stainless steel(SS)for catalytically generating NO from endogenous s-nitrosothiols(RSNO).The generated NO endows the coated surface with regulation of platelet behavior and reduction of plasmatic coagulation activation and complement system activation,hence improving antithrombotic ability in vitro and ex vivo.Overall,our NO-generating hydrogel coating surface engineering strategy provides a novel solution to remove the obstacle about thrombosis of blood-contacting devices in clinic.