Based on the special users of baby sunscreen cosmetics, the review shows how to choose forms, UV filters and how to match UV filters emphatically according to the characteristics of baby skin. Then the choosing of emo...Based on the special users of baby sunscreen cosmetics, the review shows how to choose forms, UV filters and how to match UV filters emphatically according to the characteristics of baby skin. Then the choosing of emollient, emulsifier, soothing, the design of water-resistance and the using of controversial ingredients were introduced. The review shows guidance for cosmetic formulator to design baby sunscreen cosmetics.展开更多
OBJECTIVE:To evaluate the efficacy of Renshen Sanqi Chuanxiong formula(RSCF)for preventing vascular aging,and to investigate the possible molecular mechanism underlying the actions of RSCF.METHODS:Potentially active c...OBJECTIVE:To evaluate the efficacy of Renshen Sanqi Chuanxiong formula(RSCF)for preventing vascular aging,and to investigate the possible molecular mechanism underlying the actions of RSCF.METHODS:Potentially active components and their relatively direct targets were identified by combining drug-likeness(DL)screening using a target identification process.Vascular aging-associated targets for RSCF were obtained by selecting common genes not only from potential targets but also from human vascular aging-associated genes.Cytoscape 3.2.1 software was employed to visualize the complex compound-target and target-function networks.Biological process and molecular function were assessed,and the Kyoto Encyclopedia of Genes and Genomes and pathway enrichment analyses were performed using Clue GO.Pathways directly associated with vascular aging were integrated into a"vascular aging-related"pathway.RESULTS:Altogether,122 potentially active components of RSCF were identified through DL screening,and their corresponding 692 direct targets were retrieved via target prediction and identification.We identified 49 vascular aging-associated targets for RSCF by overlapping the 692 potential targets with 146 human vascular aging-associated genes.The results from the compound-target network indicated that most components acted on common targets and displayed synergistic action,which showed that the magnifying effects of RSCF were based on these common targets.The target-function network revealed that each target was involved in multiple function modules,suggesting that RSCF was multi-functional during treatment of vascular aging.The results of the Clue GO analysis indicated that most of the targets were associated with the hypoxia-inducible factor 1(HIF-1)signaling pathway.The results from the pathway analysis also indicated that an integrative vascular aging-related pathway mainly included an angiogenesis regulation module,cell-survival module,and oxidative stress-resistance module.CONCLUSION:Our results suggested that many components act synergistically on common targets to delay vascular aging,and each target is involved in multiple functional modules.The Clue GO analysis indicated that most of the targets were connected to the HIF-1 signaling pathway,FOXO signaling pathway,and thyroid hormone signaling pathway.展开更多
目的利用可视化文献分析方法,对AI数字人的发展脉络与研究现状进行归纳与总结,并结合现阶段数字人在数字化空间中应用情况的分析,尝试推断出未来研究与发展方向。方法应用CiteSpace软件,以中国知网和Web of Science核心数据库为基础,通...目的利用可视化文献分析方法,对AI数字人的发展脉络与研究现状进行归纳与总结,并结合现阶段数字人在数字化空间中应用情况的分析,尝试推断出未来研究与发展方向。方法应用CiteSpace软件,以中国知网和Web of Science核心数据库为基础,通过发文趋势研究、核心作者分析、聚类分析和发文机构分析等方法,探索AI数字人领域的研究热点和趋势。结果AI数字人以虚拟角色形象,通过“具象化”的方式进行互动性表现,无论对数字空间的构建,还是数字交互智能化发展均具有积极的市场前景。结论国内外对AI数字人研究呈上升趋势,作者与科研机构之间的合作不断发展紧密,研究侧重点主要包括生命政治、人工智能、人机交互、媒体融合、数字乡村建设、深度学习等,将通过发展趋势分析尝试为未来研究AI数字人多样性构建提供更多思路。展开更多
文摘Based on the special users of baby sunscreen cosmetics, the review shows how to choose forms, UV filters and how to match UV filters emphatically according to the characteristics of baby skin. Then the choosing of emollient, emulsifier, soothing, the design of water-resistance and the using of controversial ingredients were introduced. The review shows guidance for cosmetic formulator to design baby sunscreen cosmetics.
基金Supported by the National Nature Science Foundation of China(the Mechamism research of Vascular Aging Induced by High Glucose from AMPK/m TOR Pathway and the Interfering Effects of Yiqi Huoxue Chinese Herbal Medicine,No.81673822,the Molecular Mechamism Research of Yiqi Huoxue Fang Postponing Vascular Endothelial Cell Senescence by SIRT1-autophagy Pathway,No.81503448)the Independent Topic Program of China Academy of Chinese Medical Sciences(Effect of Intestinal Microflora on High Glucose-induced Vascular Aging and Internention of Extracts from Radix Ginseng Radix Notoginseng and Rhizoma Chanxiong,No.ZZ2017011)
文摘OBJECTIVE:To evaluate the efficacy of Renshen Sanqi Chuanxiong formula(RSCF)for preventing vascular aging,and to investigate the possible molecular mechanism underlying the actions of RSCF.METHODS:Potentially active components and their relatively direct targets were identified by combining drug-likeness(DL)screening using a target identification process.Vascular aging-associated targets for RSCF were obtained by selecting common genes not only from potential targets but also from human vascular aging-associated genes.Cytoscape 3.2.1 software was employed to visualize the complex compound-target and target-function networks.Biological process and molecular function were assessed,and the Kyoto Encyclopedia of Genes and Genomes and pathway enrichment analyses were performed using Clue GO.Pathways directly associated with vascular aging were integrated into a"vascular aging-related"pathway.RESULTS:Altogether,122 potentially active components of RSCF were identified through DL screening,and their corresponding 692 direct targets were retrieved via target prediction and identification.We identified 49 vascular aging-associated targets for RSCF by overlapping the 692 potential targets with 146 human vascular aging-associated genes.The results from the compound-target network indicated that most components acted on common targets and displayed synergistic action,which showed that the magnifying effects of RSCF were based on these common targets.The target-function network revealed that each target was involved in multiple function modules,suggesting that RSCF was multi-functional during treatment of vascular aging.The results of the Clue GO analysis indicated that most of the targets were associated with the hypoxia-inducible factor 1(HIF-1)signaling pathway.The results from the pathway analysis also indicated that an integrative vascular aging-related pathway mainly included an angiogenesis regulation module,cell-survival module,and oxidative stress-resistance module.CONCLUSION:Our results suggested that many components act synergistically on common targets to delay vascular aging,and each target is involved in multiple functional modules.The Clue GO analysis indicated that most of the targets were connected to the HIF-1 signaling pathway,FOXO signaling pathway,and thyroid hormone signaling pathway.
文摘目的利用可视化文献分析方法,对AI数字人的发展脉络与研究现状进行归纳与总结,并结合现阶段数字人在数字化空间中应用情况的分析,尝试推断出未来研究与发展方向。方法应用CiteSpace软件,以中国知网和Web of Science核心数据库为基础,通过发文趋势研究、核心作者分析、聚类分析和发文机构分析等方法,探索AI数字人领域的研究热点和趋势。结果AI数字人以虚拟角色形象,通过“具象化”的方式进行互动性表现,无论对数字空间的构建,还是数字交互智能化发展均具有积极的市场前景。结论国内外对AI数字人研究呈上升趋势,作者与科研机构之间的合作不断发展紧密,研究侧重点主要包括生命政治、人工智能、人机交互、媒体融合、数字乡村建设、深度学习等,将通过发展趋势分析尝试为未来研究AI数字人多样性构建提供更多思路。
