This study aimed to compare the effects of bilateral cavernous nerve crushing(BCNC)and bilateral cavernous nerve resection(BCNR)on intracavernous pressure(ICP)and cavernous pathology in rats and to explore the optimal...This study aimed to compare the effects of bilateral cavernous nerve crushing(BCNC)and bilateral cavernous nerve resection(BCNR)on intracavernous pressure(ICP)and cavernous pathology in rats and to explore the optimal treatment time for the BCNC and BCNR models.Seventy-two male rats aged 12 weeks were randomly divided into three equal groups:Sham(both cavernous nerves exposed only),BCNC(BCN crushed for 2 min),and BCNR(5 mm of BCN resected).Erectile function was then measured at 1 week,3 weeks,and 5 weeks after nerve injury,and penile tissues were harvested for histological and molecular analyses by immunohistochemistry,immuno fluoresce nee,Western blot,and cytokine array.We found that erectile function parameters including the maximum,area,and slope of ICP/mean arterial pressure(MAP)significantly decreased after BCNR and BCNC at 1 week and 3 weeks.At 5 weeks,no significant differences were observed in ICP/MAP between the BCNC and Sham groups,whereas the ICP/MAP of the BCNR group remained significantly lower than that of the Sham group.After BCNC and BCNR,the amount of neuronal-nitric oxide synthase-positive fibers,smooth muscle cells,and endothelial cells decreased,whereas the amount of collage n III con tent increased.These pathological cha nges recovered over time,especially in the BCNC group.Our fin dings demonstrate that BCNC leads to acute and reversible erectile dysfunction,thus treatme nt time should be restricted to the first 3 weeks post-BCNC.In contrast,the self-healing ability of the BCNR model is poor,making it more suitable for long-term treatment research.展开更多
Today the cycle time of the product develop is requ ir ed to be shortened. At the same time the requirement of the customers becomes mo re and more diverse and complex. The capability of the develop unit is limited b ...Today the cycle time of the product develop is requ ir ed to be shortened. At the same time the requirement of the customers becomes mo re and more diverse and complex. The capability of the develop unit is limited b ecause of the existence of heterogeneous systems and distributed environments. I n this paper, we bring forward a new approach to solve the problem in product de velopment process. We also settle part key technologies in it. A great deal of information from all kinds of sources in the distributed develop ment process is interweaved. The solution to organize the workflow and manage th e information in the process is called for anxiously. We use a new approach that is asynchronous and synchronous coupling product development approach based on the network. The approach extends the develop process from the time axis. Then t he activities in the process are organized from the asynchronous and synchronous aspects. The state of every activity projects at the ASN (active semantic netwo rk). The ASN includes decision system, intelligent agent, user interface and net work. The ASN decides the types and states of the activities and deals with the couple relationship among them. The knowledge stored in ASN is open to all users through the relative interfaces. Every specialist keeps contact with their user s relying on collaborative platform implements CSCW (computer support collaborat ive work) that integrated product/process design and development. The lack of gl obal communication in product development process can be prevented in the most d egree. The key technologies that exist in the asynchronous and synchronous coupling pro duct develop approach include: integrated development structure, orderly organiz ation of information, transparent management of process, agile transfer of infor mation and rapid prototype. The development process can be completed quickly by these technologies. The technologies involve wide content. In this paper, we dis cuss some key technologies. We validate the approach by the projectrapid response manufacturing a pplication in the distributed environment. The expensive device, high technology and low using lead to RE (Rapid engineering) and RP (Rapid prototype) service a pplication by the network. RE and RP develop rapidly due to the accelerated prod uct development process. RE and RP application service platform is built in the project.展开更多
The relationship between infrared light （IR） and vacuum ultraviolet （VUV） emission in shadow mask plasma display panels （SMPDP） at high xenon content and high voltage is investigated. The respective ratios of VI...The relationship between infrared light （IR） and vacuum ultraviolet （VUV） emission in shadow mask plasma display panels （SMPDP） at high xenon content and high voltage is investigated. The respective ratios of VIS/IR-823 am, VIS/IR-828 nm and of efficacy/VIS/IR-823 nm, efficacy/VIS/IR-823 nm are calculated to determine the behavior of the xenon excitation efficiency and the electron excitation efficiency as a function of the driving voltage and xenon content. It is found that the xenon excitation efficiency is almost independent of the driving voltage, and increases approximately linearly with the xenon content. The values for efficacy/VIS/IR-828 nm increase rapidly with the xenon content, but saturate at a xenon ratio of about 30% while, on the other hand, the efficacy/VIS/IR-823 nm values decrease continuously with the xenon content.展开更多
This paper presents an original interpretation of the Upanishads that the inner self is located in the embryo brain region of the brain. This is the part of the brain already present in the embryo and consists of the ...This paper presents an original interpretation of the Upanishads that the inner self is located in the embryo brain region of the brain. This is the part of the brain already present in the embryo and consists of the brainstem, hypothalamus, thalamus, and midbrain. It is also the part of the brain that operates during dreaming and deep sleep and causes the transition from sleeping to waking states, and the Upanishads state unequivocally that the self is responsible for these mental states. With the self located in the embryo brain region, an entirely new interpretation of Aristotle＇s De Anima is presented which parallels the Upanishads in every respect; the inner self and Aristotle＇s ＂soul＂ have identical functions and attributes. An Aristotelian First Principle is presented： Biology is the source of Consciousness; DNA is the source of Biology; Ergo DNA is the source of Consciousness.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.81671450).
文摘This study aimed to compare the effects of bilateral cavernous nerve crushing(BCNC)and bilateral cavernous nerve resection(BCNR)on intracavernous pressure(ICP)and cavernous pathology in rats and to explore the optimal treatment time for the BCNC and BCNR models.Seventy-two male rats aged 12 weeks were randomly divided into three equal groups:Sham(both cavernous nerves exposed only),BCNC(BCN crushed for 2 min),and BCNR(5 mm of BCN resected).Erectile function was then measured at 1 week,3 weeks,and 5 weeks after nerve injury,and penile tissues were harvested for histological and molecular analyses by immunohistochemistry,immuno fluoresce nee,Western blot,and cytokine array.We found that erectile function parameters including the maximum,area,and slope of ICP/mean arterial pressure(MAP)significantly decreased after BCNR and BCNC at 1 week and 3 weeks.At 5 weeks,no significant differences were observed in ICP/MAP between the BCNC and Sham groups,whereas the ICP/MAP of the BCNR group remained significantly lower than that of the Sham group.After BCNC and BCNR,the amount of neuronal-nitric oxide synthase-positive fibers,smooth muscle cells,and endothelial cells decreased,whereas the amount of collage n III con tent increased.These pathological cha nges recovered over time,especially in the BCNC group.Our fin dings demonstrate that BCNC leads to acute and reversible erectile dysfunction,thus treatme nt time should be restricted to the first 3 weeks post-BCNC.In contrast,the self-healing ability of the BCNR model is poor,making it more suitable for long-term treatment research.
文摘Today the cycle time of the product develop is requ ir ed to be shortened. At the same time the requirement of the customers becomes mo re and more diverse and complex. The capability of the develop unit is limited b ecause of the existence of heterogeneous systems and distributed environments. I n this paper, we bring forward a new approach to solve the problem in product de velopment process. We also settle part key technologies in it. A great deal of information from all kinds of sources in the distributed develop ment process is interweaved. The solution to organize the workflow and manage th e information in the process is called for anxiously. We use a new approach that is asynchronous and synchronous coupling product development approach based on the network. The approach extends the develop process from the time axis. Then t he activities in the process are organized from the asynchronous and synchronous aspects. The state of every activity projects at the ASN (active semantic netwo rk). The ASN includes decision system, intelligent agent, user interface and net work. The ASN decides the types and states of the activities and deals with the couple relationship among them. The knowledge stored in ASN is open to all users through the relative interfaces. Every specialist keeps contact with their user s relying on collaborative platform implements CSCW (computer support collaborat ive work) that integrated product/process design and development. The lack of gl obal communication in product development process can be prevented in the most d egree. The key technologies that exist in the asynchronous and synchronous coupling pro duct develop approach include: integrated development structure, orderly organiz ation of information, transparent management of process, agile transfer of infor mation and rapid prototype. The development process can be completed quickly by these technologies. The technologies involve wide content. In this paper, we dis cuss some key technologies. We validate the approach by the projectrapid response manufacturing a pplication in the distributed environment. The expensive device, high technology and low using lead to RE (Rapid engineering) and RP (Rapid prototype) service a pplication by the network. RE and RP develop rapidly due to the accelerated prod uct development process. RE and RP application service platform is built in the project.
基金supported by National Natural Science Foundation of China (No. 60571033)the National Hi'Tech projects of China (No. 2008AA03A308)Programme of Introducing Talents of Discipline to Universities of China (B07027)
文摘The relationship between infrared light （IR） and vacuum ultraviolet （VUV） emission in shadow mask plasma display panels （SMPDP） at high xenon content and high voltage is investigated. The respective ratios of VIS/IR-823 am, VIS/IR-828 nm and of efficacy/VIS/IR-823 nm, efficacy/VIS/IR-823 nm are calculated to determine the behavior of the xenon excitation efficiency and the electron excitation efficiency as a function of the driving voltage and xenon content. It is found that the xenon excitation efficiency is almost independent of the driving voltage, and increases approximately linearly with the xenon content. The values for efficacy/VIS/IR-828 nm increase rapidly with the xenon content, but saturate at a xenon ratio of about 30% while, on the other hand, the efficacy/VIS/IR-823 nm values decrease continuously with the xenon content.
文摘This paper presents an original interpretation of the Upanishads that the inner self is located in the embryo brain region of the brain. This is the part of the brain already present in the embryo and consists of the brainstem, hypothalamus, thalamus, and midbrain. It is also the part of the brain that operates during dreaming and deep sleep and causes the transition from sleeping to waking states, and the Upanishads state unequivocally that the self is responsible for these mental states. With the self located in the embryo brain region, an entirely new interpretation of Aristotle＇s De Anima is presented which parallels the Upanishads in every respect; the inner self and Aristotle＇s ＂soul＂ have identical functions and attributes. An Aristotelian First Principle is presented： Biology is the source of Consciousness; DNA is the source of Biology; Ergo DNA is the source of Consciousness.
