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Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla 被引量:5
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作者 Xin Wei Li-Ping Jiang +11 位作者 Ying Guo Afsar Khan Ya-Ping Liu Hao-Fei Yu Bei Wang Cai-Feng Ding Pei-Feng Zhu Ying-Ying Chen Yun-Li Zhao Yong-Bing Chen Yi-Fen Wang Xiao-Dong Luo 《Natural Products and Bioprospecting》 CAS 2017年第5期413-419,共7页
Uncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness,cerebrovascular diseases,and nervous disorders in China.Previously,the neuro-protective activities of the alkaloids from U.rhyncho... Uncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness,cerebrovascular diseases,and nervous disorders in China.Previously,the neuro-protective activities of the alkaloids from U.rhynchophylla were intensively reported.In current work,three new indole alkaloids(1–3),identified as geissoschizic acid(1),geissoschizic acid N4-oxide(2),and 3b-sitsirikine N4-oxide(3),as well as 26 known analogues were isolated from U.rhynchophylla.However,in the neural stem cells(NSCs)proliferation assay for all isolated compounds,geissoschizic acid(1),geissoschizic acid N4-oxide(2),isocorynoxeine(6),isorhynchophylline(7),(4S)-akuammigine N-oxide(8),and(4S)-rhynchophylline N-oxide(10)showed unexpected inhibitory activities at 10 μM.Unlike previous neuro-protective reports,as a warning or caution,our finding showcased a clue for possible NSCs toxicity and the neural lesions risk of U.rhynchophylla,while the structure–activity relationships of the isolated compounds were discussed also. 展开更多
关键词 Uncaria rhynchophylla Indole alkaloids nscs proliferation
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