This paper expresses the efficient outputs of decisionmaking unit（DMU） as the sum of ＂average outputs＂ forecasted by a GM（1,N） model and ＂increased outputs＂ which reflect the difficulty to realize efficient ou...This paper expresses the efficient outputs of decisionmaking unit（DMU） as the sum of ＂average outputs＂ forecasted by a GM（1,N） model and ＂increased outputs＂ which reflect the difficulty to realize efficient outputs.The increased outputs are solved by linear programming using data envelopment analysis efficiency theories,wherein a new sample is introduced whose inputs are equal to the budget in the issue No.n ＋ 1 and outputs are forecasted by the GM（1,N） model.The shortcoming in the existing methods that the forecasted efficient outputs may be less than the possible actual outputs according to developing trends of input-output rate in the periods of pre-n is overcome.The new prediction method provides decision-makers with more decisionmaking information,and the initial conditions are easy to be given.展开更多
The genome characteristics and structural functions of coding proteins correlate with the genetic diversity of the H1N1 virus,which aids in the understanding of its underlying pathogenic mechanism.In this study,analys...The genome characteristics and structural functions of coding proteins correlate with the genetic diversity of the H1N1 virus,which aids in the understanding of its underlying pathogenic mechanism.In this study,analyses of the characteristic of the H1N1 virus infection-related genes,their biological functions,and infection-related reversal drugs were performed.Additionally,we used multi-dimensional bioinformatics analysis to identify the key genes and then used these to construct a diagnostic model for the H1N1 virus infection.There was a total of 169 differently expressed genes in the samples between 21 h before infection and 77 h after infection.They were used during the protein-protein interaction(PPI)analysis,and we obtained a total of 1725 interacting genes.Then,we performed a weighted gene co-expression network analysis(WGCNA)on these genes,and we identified three modules that showed significant potential for the diagnosis of the H1N1 virus infection.These modules contained 60 genes,and they were used to construct this diagnostic model,which showed an effective prediction value.Besides,these 60 genes were involved in the biological functions of this infectious virus,like the cellular response to type I interferon and in the negative regulation of the viral life cycle.However,20 genes showed an upregulated expression as the infection progressed.Other 36 upregulated genes were used to examine the relationship between genes,human influenza A virus,and infection-related reversal drugs.This study revealed numerous important reversal drug molecules on the H1N1 virus.They included rimantadine,interferons,and shikimic acid.Our study provided a novel method to analyze the characteristic of different genes and explore their corresponding biological function during the infection caused by the H1N1 virus.This diagnostic model,which comprises 60 genes,shows that a significant predictive value can be the potential biomarker for the diagnosis of the H1N1 virus infection.展开更多
Objective To evaluate the effect of the aluminum hydroxide （Al-OH） adjuvant on the 2009 pandemic influenza A/H1N1 （pH1N1） vaccine. Methods In a multicenter, double-blind, randomized, placebo-controlled trial, part...Objective To evaluate the effect of the aluminum hydroxide （Al-OH） adjuvant on the 2009 pandemic influenza A/H1N1 （pH1N1） vaccine. Methods In a multicenter, double-blind, randomized, placebo-controlled trial, participants received two doses of split-virion formulation containing 15 ug hemagglutinin antigen, with or without aluminum hydroxide （N-OH）. We classified the participants into six age categories （〉61 years, 41-60 years, 19-40 years, 13-18 years, 8-12 years, and 3-7 years） and obtained four blood samples from each participant on days 0, 21, 35, and 42 following the first dose of immunization. We assessed vaccine immunogenicity by measuring the geometric mean titer （GMT） of hemagglutination inhibiting antibody. We used a two-level model to evaluate the fixed effect of aluminum Al-OH and other factors, accounting for repeated measures. Results The predictions of repeated measurement on GMTs of formulations with or without Al-OH, were 80.35 and 112.72, respectively. Al-OH significantly reduced immunogenicity after controlling for time post immunization, age-group and gender. Conclusion The Al-OH adjuvant does not increase but actually reduces the immunogenicity of the split-virion pH1N1 vaccine.展开更多
In this paper, based on the Science and Technology Statistics in Beijing Statistical Yearbook, grey theory is used to study the relationship among S&T (Science and Technology) activities personnel, R&D (resear...In this paper, based on the Science and Technology Statistics in Beijing Statistical Yearbook, grey theory is used to study the relationship among S&T (Science and Technology) activities personnel, R&D (research and development) personnel FTE (Full Time Equivalent), intramural expenditure for R&D and Patent Application Amount. According to the grey correlation coefficient, screening of grey GM(1,N) prediction variables, the grey prediction model is established. Meanwhile, time series model and GM(1,1) model are established for patent applications and R&D personnel equivalent FTE. By comparing the simulating results with the real data, the absolute relative error of prediction models is less than 10%. The results of the prediction model are tested. In order to improve the prediction accuracy, the mean values of the predicted values of the two models are brought into the GM(1,N) model to predict the number of scientific and technical personnel in Beijing during 2015-2025. Forecast results show that the number of science and technology personnel in Beijing will grow with exponential growth trend in the next ten years, which has a certain reference value for predicting the science and technology activities and formulating the policy in Beijing.展开更多
Through 40 years of reform and open-up,China’s system is no longer a monocentric one of centralized control and at the same time neither is it a polycentric one,but rather it is a"1+N"centric model of gover...Through 40 years of reform and open-up,China’s system is no longer a monocentric one of centralized control and at the same time neither is it a polycentric one,but rather it is a"1+N"centric model of governance.It is a model that combines polycentric with monocentric with several centers,all of which however are centering on a mono-center.展开更多
对未来R&D经费总量及其与GDP比值进行科学的预测是制定科技发展规划的重要组成部分.提出一种定量分析预测方法———利用多变量灰色MGM(1,n)模型(mu lti-variab le grey model),研究R&D投入与GDP所形成的复杂系统变量之间的相...对未来R&D经费总量及其与GDP比值进行科学的预测是制定科技发展规划的重要组成部分.提出一种定量分析预测方法———利用多变量灰色MGM(1,n)模型(mu lti-variab le grey model),研究R&D投入与GDP所形成的复杂系统变量之间的相互影响关系,对天津市相关数据资料进行实证分析与中长期预测,为政府相关部门制订科学的科技发展规划提供有益的指导作用.展开更多
基金supported by the Research Start Funds for Introducing High-level Talents of North China University of Water Resources and Electric Power
文摘This paper expresses the efficient outputs of decisionmaking unit（DMU） as the sum of ＂average outputs＂ forecasted by a GM（1,N） model and ＂increased outputs＂ which reflect the difficulty to realize efficient outputs.The increased outputs are solved by linear programming using data envelopment analysis efficiency theories,wherein a new sample is introduced whose inputs are equal to the budget in the issue No.n ＋ 1 and outputs are forecasted by the GM（1,N） model.The shortcoming in the existing methods that the forecasted efficient outputs may be less than the possible actual outputs according to developing trends of input-output rate in the periods of pre-n is overcome.The new prediction method provides decision-makers with more decisionmaking information,and the initial conditions are easy to be given.
基金supported by the major national S&T projects for infectious diseases(2018ZX10301401)the Key Research&Development Plan of Zhejiang Province(2019C04005)the National Key Research,and the Development Program of China(2018YFC2000500).
文摘The genome characteristics and structural functions of coding proteins correlate with the genetic diversity of the H1N1 virus,which aids in the understanding of its underlying pathogenic mechanism.In this study,analyses of the characteristic of the H1N1 virus infection-related genes,their biological functions,and infection-related reversal drugs were performed.Additionally,we used multi-dimensional bioinformatics analysis to identify the key genes and then used these to construct a diagnostic model for the H1N1 virus infection.There was a total of 169 differently expressed genes in the samples between 21 h before infection and 77 h after infection.They were used during the protein-protein interaction(PPI)analysis,and we obtained a total of 1725 interacting genes.Then,we performed a weighted gene co-expression network analysis(WGCNA)on these genes,and we identified three modules that showed significant potential for the diagnosis of the H1N1 virus infection.These modules contained 60 genes,and they were used to construct this diagnostic model,which showed an effective prediction value.Besides,these 60 genes were involved in the biological functions of this infectious virus,like the cellular response to type I interferon and in the negative regulation of the viral life cycle.However,20 genes showed an upregulated expression as the infection progressed.Other 36 upregulated genes were used to examine the relationship between genes,human influenza A virus,and infection-related reversal drugs.This study revealed numerous important reversal drug molecules on the H1N1 virus.They included rimantadine,interferons,and shikimic acid.Our study provided a novel method to analyze the characteristic of different genes and explore their corresponding biological function during the infection caused by the H1N1 virus.This diagnostic model,which comprises 60 genes,shows that a significant predictive value can be the potential biomarker for the diagnosis of the H1N1 virus infection.
基金supported by the Infectious Disease Prevention and Control Major Research plan from the Ministry of Science and Technology of China-the Platform of Construction of Clinical Trial of Vaccine. (Project number 2009ZX0004-806)
文摘Objective To evaluate the effect of the aluminum hydroxide （Al-OH） adjuvant on the 2009 pandemic influenza A/H1N1 （pH1N1） vaccine. Methods In a multicenter, double-blind, randomized, placebo-controlled trial, participants received two doses of split-virion formulation containing 15 ug hemagglutinin antigen, with or without aluminum hydroxide （N-OH）. We classified the participants into six age categories （〉61 years, 41-60 years, 19-40 years, 13-18 years, 8-12 years, and 3-7 years） and obtained four blood samples from each participant on days 0, 21, 35, and 42 following the first dose of immunization. We assessed vaccine immunogenicity by measuring the geometric mean titer （GMT） of hemagglutination inhibiting antibody. We used a two-level model to evaluate the fixed effect of aluminum Al-OH and other factors, accounting for repeated measures. Results The predictions of repeated measurement on GMTs of formulations with or without Al-OH, were 80.35 and 112.72, respectively. Al-OH significantly reduced immunogenicity after controlling for time post immunization, age-group and gender. Conclusion The Al-OH adjuvant does not increase but actually reduces the immunogenicity of the split-virion pH1N1 vaccine.
文摘In this paper, based on the Science and Technology Statistics in Beijing Statistical Yearbook, grey theory is used to study the relationship among S&T (Science and Technology) activities personnel, R&D (research and development) personnel FTE (Full Time Equivalent), intramural expenditure for R&D and Patent Application Amount. According to the grey correlation coefficient, screening of grey GM(1,N) prediction variables, the grey prediction model is established. Meanwhile, time series model and GM(1,1) model are established for patent applications and R&D personnel equivalent FTE. By comparing the simulating results with the real data, the absolute relative error of prediction models is less than 10%. The results of the prediction model are tested. In order to improve the prediction accuracy, the mean values of the predicted values of the two models are brought into the GM(1,N) model to predict the number of scientific and technical personnel in Beijing during 2015-2025. Forecast results show that the number of science and technology personnel in Beijing will grow with exponential growth trend in the next ten years, which has a certain reference value for predicting the science and technology activities and formulating the policy in Beijing.
文摘Through 40 years of reform and open-up,China’s system is no longer a monocentric one of centralized control and at the same time neither is it a polycentric one,but rather it is a"1+N"centric model of governance.It is a model that combines polycentric with monocentric with several centers,all of which however are centering on a mono-center.
文摘对未来R&D经费总量及其与GDP比值进行科学的预测是制定科技发展规划的重要组成部分.提出一种定量分析预测方法———利用多变量灰色MGM(1,n)模型(mu lti-variab le grey model),研究R&D投入与GDP所形成的复杂系统变量之间的相互影响关系,对天津市相关数据资料进行实证分析与中长期预测,为政府相关部门制订科学的科技发展规划提供有益的指导作用.
