Triterpene acids components in leaves of Rosmarinus officinalis Linn.were separated and identified by HPLC,silica gel column chromatography and reversed-phase C18 semi-preparative liquid chromatography method.And taki...Triterpene acids components in leaves of Rosmarinus officinalis Linn.were separated and identified by HPLC,silica gel column chromatography and reversed-phase C18 semi-preparative liquid chromatography method.And taking the minimum inhibitory concentration(MIC)as the index,the inhibitory activity of each compound was determined.The results show that 4 triterpene acids compounds are isolated from ethanol extracts of leaves of R.officinalis;according to the peak characteristics of reference substances,compound 2,3 and 4 are identified as betulinic acid,oleanolic acid and ursolic acid,respectively;based on physicochemical constants and spectral data,compound 1 is identified asΔ^20(30)-ene-ursolic acid.Ursolic acid,Δ^20(30)-ene-ursolic acid and oleanolic acid have a certain inhibitory activity to Gram-positive strains(methicillin-resistant Staphylococcus aureus,MRSA),in which,the MIC value of ursolic acid to MRSA is 8.000-128.000μg·mL-1,and its inhibitory activity is the strongest;however,none of 4 compounds shows inhibitory activity to Gram-negative strain(Escherichia coli S002).展开更多
AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori-neg...AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was perform- ed on the day of treatment. Blood samples were also collected after the administration of each drug. RESULTS: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. CONCLUSION: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg.展开更多
目的探究不同起始浓度氧复苏方案对足月新生儿窒息抢救的效果。方法选取2018年7月~2019年12月我院收入治疗的60例足月新生儿窒息患儿的临床资料,按照起始浓度氧复苏的不同分为对照组与观察组,每组各30例。对照组采用21%氧浓度复苏治疗,...目的探究不同起始浓度氧复苏方案对足月新生儿窒息抢救的效果。方法选取2018年7月~2019年12月我院收入治疗的60例足月新生儿窒息患儿的临床资料,按照起始浓度氧复苏的不同分为对照组与观察组,每组各30例。对照组采用21%氧浓度复苏治疗,观察组采用30%氧浓度复苏治疗。比较两组首次啼哭时间、自主呼吸时间、复苏抢救5 min时的心率、增氧复苏率、脑损伤发生率、复苏成功率、氧中毒发生率及治疗后的1、5、10 min的新生儿Apgar评分。结果两组脑损伤发生率、复苏成功率及复苏抢救5 min时的心率比较,差异无统计学意义(P>0.05);观察组增氧复苏率(3.33%)、氧中毒发生率(0.00%)低于对照组(26.66%、20.00%),差异有统计学意义(P<0.05);观察组首次啼哭时间、自主呼吸时间均短于对照组,差异有统计学意义(P<0.05);两组1 min Apgar评分比较,差异无统计学意义(P>0.05),而观察组5、10 min Apgar评分高于对照组,差异有统计学意义(P<0.05)。结论对足月新生儿窒息抢救治疗效果而言,采用30%氧浓度与21%氧浓度进行复苏治疗效果相当,且安全可靠,但采用30%氧浓度复苏治疗足月新生儿窒息可有效降低患儿脑损伤率,缩短患儿自主呼吸与首次啼哭时间,提高Apgar评分,值得临床推广应用。展开更多
文摘Triterpene acids components in leaves of Rosmarinus officinalis Linn.were separated and identified by HPLC,silica gel column chromatography and reversed-phase C18 semi-preparative liquid chromatography method.And taking the minimum inhibitory concentration(MIC)as the index,the inhibitory activity of each compound was determined.The results show that 4 triterpene acids compounds are isolated from ethanol extracts of leaves of R.officinalis;according to the peak characteristics of reference substances,compound 2,3 and 4 are identified as betulinic acid,oleanolic acid and ursolic acid,respectively;based on physicochemical constants and spectral data,compound 1 is identified asΔ^20(30)-ene-ursolic acid.Ursolic acid,Δ^20(30)-ene-ursolic acid and oleanolic acid have a certain inhibitory activity to Gram-positive strains(methicillin-resistant Staphylococcus aureus,MRSA),in which,the MIC value of ursolic acid to MRSA is 8.000-128.000μg·mL-1,and its inhibitory activity is the strongest;however,none of 4 compounds shows inhibitory activity to Gram-negative strain(Escherichia coli S002).
文摘AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was perform- ed on the day of treatment. Blood samples were also collected after the administration of each drug. RESULTS: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. CONCLUSION: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg.
文摘目的探究不同起始浓度氧复苏方案对足月新生儿窒息抢救的效果。方法选取2018年7月~2019年12月我院收入治疗的60例足月新生儿窒息患儿的临床资料,按照起始浓度氧复苏的不同分为对照组与观察组,每组各30例。对照组采用21%氧浓度复苏治疗,观察组采用30%氧浓度复苏治疗。比较两组首次啼哭时间、自主呼吸时间、复苏抢救5 min时的心率、增氧复苏率、脑损伤发生率、复苏成功率、氧中毒发生率及治疗后的1、5、10 min的新生儿Apgar评分。结果两组脑损伤发生率、复苏成功率及复苏抢救5 min时的心率比较,差异无统计学意义(P>0.05);观察组增氧复苏率(3.33%)、氧中毒发生率(0.00%)低于对照组(26.66%、20.00%),差异有统计学意义(P<0.05);观察组首次啼哭时间、自主呼吸时间均短于对照组,差异有统计学意义(P<0.05);两组1 min Apgar评分比较,差异无统计学意义(P>0.05),而观察组5、10 min Apgar评分高于对照组,差异有统计学意义(P<0.05)。结论对足月新生儿窒息抢救治疗效果而言,采用30%氧浓度与21%氧浓度进行复苏治疗效果相当,且安全可靠,但采用30%氧浓度复苏治疗足月新生儿窒息可有效降低患儿脑损伤率,缩短患儿自主呼吸与首次啼哭时间,提高Apgar评分,值得临床推广应用。
