Two new norditerpenoid alkaloids were isolated from the roots of Aconitum nagarum.Their structures were elucidated as 13-hydroxyfranchetine 1 and 10-dehydroxyflavaconitine 2,respectively, by 1D and 2D NMR experiments.
Four new diterpenoid alkaloids,nagaconitines A-D（1-4）,were isolated from the roots of Aconitum nagarum var.heterotrichum.Their structures were elucidated as 8-（4＇-hydroxylbutyryl） aconitine（1）,15-oxo-13-deoxylu...Four new diterpenoid alkaloids,nagaconitines A-D（1-4）,were isolated from the roots of Aconitum nagarum var.heterotrichum.Their structures were elucidated as 8-（4＇-hydroxylbutyryl） aconitine（1）,15-oxo-13-deoxyludaconitine（2）,15-hydroxyldelphisine（3）,and 14-hydroxyl-2- acetoxyspiradine C（4）based on extensive UV,IR,MS,1D NMR and 2D NMR analyses.Compounds 3-4 showed inhibition of cancer cell line SK-OV-3 with 31%（IC_（50） 43.78 μmol/L） and 24%（IC_（50） 32.14 μmol/L）,respectively.展开更多
文摘Two new norditerpenoid alkaloids were isolated from the roots of Aconitum nagarum.Their structures were elucidated as 13-hydroxyfranchetine 1 and 10-dehydroxyflavaconitine 2,respectively, by 1D and 2D NMR experiments.
基金supported by the National Natural Science Foundation of China (Nos. 21362045, 81560622)the project of Sciences and Technology Department of Yunnan Province (No. 2012CG007)
文摘Four new diterpenoid alkaloids,nagaconitines A-D（1-4）,were isolated from the roots of Aconitum nagarum var.heterotrichum.Their structures were elucidated as 8-（4＇-hydroxylbutyryl） aconitine（1）,15-oxo-13-deoxyludaconitine（2）,15-hydroxyldelphisine（3）,and 14-hydroxyl-2- acetoxyspiradine C（4）based on extensive UV,IR,MS,1D NMR and 2D NMR analyses.Compounds 3-4 showed inhibition of cancer cell line SK-OV-3 with 31%（IC_（50） 43.78 μmol/L） and 24%（IC_（50） 32.14 μmol/L）,respectively.
