The objective of the current study is to investigate the importance of entropy generation and thermal radiation on the patterns of velocity,isentropic lines,and temperature contours within a thermal energy storage dev...The objective of the current study is to investigate the importance of entropy generation and thermal radiation on the patterns of velocity,isentropic lines,and temperature contours within a thermal energy storage device filled with magnetic nanoencapsulated phase change materials(NEPCMs).The versatile finite element method(FEM)is implemented to numerically solve the governing equations.The effects of various parameters,including the viscosity parameter,ranging from 1 to 3,the thermal conductivity parameter,ranging from 1 to 3,the Rayleigh parameter,ranging from 102 to 3×10^(2),the radiation number,ranging from 0.1 to 0.5,the fusion temperature,ranging from 1.0 to 1.2,the volume fraction of NEPCMs,ranging from 2%to 6%,the Stefan number,ranging from 1 to 5,the magnetic number,ranging from 0.1 to 0.5,and the irreversibility parameter,ranging from 0.1 to 0.5,are examined in detail on the temperature contours,isentropic lines,heat capacity ratio,and velocity fields.Furthermore,the heat transfer rates at both the cold and hot walls are analyzed,and the findings are presented graphically.The results indicate that the time taken by the NEPCMs to transition from solid to liquid is prolonged inside the chamber region as the fusion temperatureθf increases.Additionally,the contours of the heat capacity ratio Cr decrease with the increase in the Stefan number Ste.展开更多
This Article presents a three dimensional numerical model investigating thermal performance and hydrodynamics features of the confined slot jet impingement using slurry of Nano Encapsulated Phase Change Material(NEPCM...This Article presents a three dimensional numerical model investigating thermal performance and hydrodynamics features of the confined slot jet impingement using slurry of Nano Encapsulated Phase Change Material(NEPCM)as a coolant.The slurry is composed of water as a base fluid and n-octadecane NEPCM particles with mean diameter of 100 nm suspended in it.A single phase fluid approach is employed to model the NEPCM slurry.The thermo physical properties of the NEPCM slurry are computed using modern approaches being proposed recently and governing equations are solved with a commercial Finite Volume based code.The effects of jet Reynolds number varying from 100 to 600 and particle volume fraction ranging from 0% to 28% are considered.The computed results are validated by comparing Nusselt number values at stagnation point with the previously published results with water as working fluid.It was found that adding NEPCM to the base fluid results with considerable amount of heat transfer enhancement.The highest values of heat transfer coefficients are observed at H/W=4 and C_m=0.28.However,due to the higher viscosity of slurry compared with the base fluid,the slurry can produce drastic increase in pressure drop of the system that increases with NEPCM particle loading and jet Reynolds number.展开更多
Short in vivo circulation is a major hindrance to the widespread adoption of protein therapeutics. Protein nanocapsules generated by encapsulating proteins with a thin layer of phosphorylcholine-based polymer via a tw...Short in vivo circulation is a major hindrance to the widespread adoption of protein therapeutics. Protein nanocapsules generated by encapsulating proteins with a thin layer of phosphorylcholine-based polymer via a two-step encapsulation process exhibited significantly prolonged plasma half-life. Furthermore, by constructing nanocapsules with similar sizes but different surface charges and chemistry, we demonstrated a generic strategy for prolonging the plasma half-life of therapeutic proteins. In an in vitro experiment, four types of bovine serum albumin (BSA) nanocapsules were incubated with fetal bovine serum (FBS) in phosphate buffer saline (PBS); the cell uptake by HeLa cells was monitored to systematically evaluate the characteristics of the surface chemistry during drculation. Single positron emission tomography-computed tomography (SPECT) was employed to allow real-time observation of the BSA nanoparticle distribution in vivo, as well as quantification of the plasma concentration after intravenous administration. This study offers a practical method for translating a broad range of proteins for clinical use.展开更多
文摘The objective of the current study is to investigate the importance of entropy generation and thermal radiation on the patterns of velocity,isentropic lines,and temperature contours within a thermal energy storage device filled with magnetic nanoencapsulated phase change materials(NEPCMs).The versatile finite element method(FEM)is implemented to numerically solve the governing equations.The effects of various parameters,including the viscosity parameter,ranging from 1 to 3,the thermal conductivity parameter,ranging from 1 to 3,the Rayleigh parameter,ranging from 102 to 3×10^(2),the radiation number,ranging from 0.1 to 0.5,the fusion temperature,ranging from 1.0 to 1.2,the volume fraction of NEPCMs,ranging from 2%to 6%,the Stefan number,ranging from 1 to 5,the magnetic number,ranging from 0.1 to 0.5,and the irreversibility parameter,ranging from 0.1 to 0.5,are examined in detail on the temperature contours,isentropic lines,heat capacity ratio,and velocity fields.Furthermore,the heat transfer rates at both the cold and hot walls are analyzed,and the findings are presented graphically.The results indicate that the time taken by the NEPCMs to transition from solid to liquid is prolonged inside the chamber region as the fusion temperatureθf increases.Additionally,the contours of the heat capacity ratio Cr decrease with the increase in the Stefan number Ste.
基金supported by the National Natural Science Foundation of China(No.51322604)
文摘This Article presents a three dimensional numerical model investigating thermal performance and hydrodynamics features of the confined slot jet impingement using slurry of Nano Encapsulated Phase Change Material(NEPCM)as a coolant.The slurry is composed of water as a base fluid and n-octadecane NEPCM particles with mean diameter of 100 nm suspended in it.A single phase fluid approach is employed to model the NEPCM slurry.The thermo physical properties of the NEPCM slurry are computed using modern approaches being proposed recently and governing equations are solved with a commercial Finite Volume based code.The effects of jet Reynolds number varying from 100 to 600 and particle volume fraction ranging from 0% to 28% are considered.The computed results are validated by comparing Nusselt number values at stagnation point with the previously published results with water as working fluid.It was found that adding NEPCM to the base fluid results with considerable amount of heat transfer enhancement.The highest values of heat transfer coefficients are observed at H/W=4 and C_m=0.28.However,due to the higher viscosity of slurry compared with the base fluid,the slurry can produce drastic increase in pressure drop of the system that increases with NEPCM particle loading and jet Reynolds number.
基金This work is supported by the National Natural Science Foundation of China (NSFC, Nos. 51343007, 81271612 and 81401439), Shanghai Pujiang Program (No. 13PJD022), and Shanghai Health Bureau Fund (No. 20124016).
文摘Short in vivo circulation is a major hindrance to the widespread adoption of protein therapeutics. Protein nanocapsules generated by encapsulating proteins with a thin layer of phosphorylcholine-based polymer via a two-step encapsulation process exhibited significantly prolonged plasma half-life. Furthermore, by constructing nanocapsules with similar sizes but different surface charges and chemistry, we demonstrated a generic strategy for prolonging the plasma half-life of therapeutic proteins. In an in vitro experiment, four types of bovine serum albumin (BSA) nanocapsules were incubated with fetal bovine serum (FBS) in phosphate buffer saline (PBS); the cell uptake by HeLa cells was monitored to systematically evaluate the characteristics of the surface chemistry during drculation. Single positron emission tomography-computed tomography (SPECT) was employed to allow real-time observation of the BSA nanoparticle distribution in vivo, as well as quantification of the plasma concentration after intravenous administration. This study offers a practical method for translating a broad range of proteins for clinical use.