The aim of the present investigation was to develop a biosensor for the detection of amino acids, Leucine, Isoleucine and Valine based on a quartz crystal nanobalance. leucine (Leu), isoleucine (Ile), and valine (Val)...The aim of the present investigation was to develop a biosensor for the detection of amino acids, Leucine, Isoleucine and Valine based on a quartz crystal nanobalance. leucine (Leu), isoleucine (Ile), and valine (Val) were selectively determined by quartz crystal nanobalance (QCN) sensor in conjunction with net analyte signal (NAS)-based method called HLA/GO. An orthogonal design was applied for the formation of calibration and prediction sets including Leu, Ile and Val compounds. The selection of the optimal time range involved the calculation of the net analyte sig-nal regression plot in any considered time window for each test sample. The searching of a region with maximum linearity of NAS regression plot (minimum error indicator) and minimum of PRESS value was carried out by applying a moving window strategy. On the base of obtained results, the differences on the adsorption profiles in the time range between 1 and 300 s were used to determine mixtures of compounds by HLA/GO method. The results showed that the method was successfully applied for the determina-tion of Leu, Ile and Val.展开更多
The Chinese iron pan can function as a nonstick pan even without a polytetrafluoroethylene(PTFE)coating after a“Kitchen God blessing”seasoning process.We simulate this process and disclose the science behind the“Ki...The Chinese iron pan can function as a nonstick pan even without a polytetrafluoroethylene(PTFE)coating after a“Kitchen God blessing”seasoning process.We simulate this process and disclose the science behind the“Kitchen God blessing,”finding that through repeated oil-coating and heating,the reversible insertion and extraction of oxygen atoms split the surface of the iron pan,gradually producing Fe 3 O 4 nanoballs.These balls give the iron pan a conditional hydrophobicity property,meaning the pan would be hydrophilic when the ingredients contain much water and hydrophobic when they contain less water.The former enables heat to be transferred rapidly through the nanoballs while the latter slows down the heat transference and prevents the pan from sticking.This discovery provides an approach of generating nanoballs on the surface of the metal and also discloses the secret of the fantastic taste produced by cooking with a Chinese iron pan.展开更多
Plasmonic nanostructure-mediated photothermal therapy(PTT) has proven to be a promising approach for cancer treatment,and new approaches for its effective delivery to tumor lesions are currently being developed.This s...Plasmonic nanostructure-mediated photothermal therapy(PTT) has proven to be a promising approach for cancer treatment,and new approaches for its effective delivery to tumor lesions are currently being developed.This study aimed to assess macrophage-mediated delivery of PTT using radioiodine-124-labeled gold nanoparticles with crushed gold shells(124I-Au@AuCBs) as a theranostic nanoplatform.124I-Au@AuCBs exhibited effective photothermal conversion effects both in vitro and in vivo and were efficiently taken up by macrophages without cytotoxicity.After the administration of 124I-Au@AuCB-labeled macrophages to colon tumors,intensive signals were observed at tumor lesions,and subsequent in vivo PTT with laser irradiation yielded potent antitumor effects.The results indicate the considerable potential of 124I-Au@AuCBs as novel theranostic nanomaterials and the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases.展开更多
A novel fullerene-styrene-maleic anhydride copolymer is reported. TEM analyses shows it is water- soluble nanoball of average diameter of about 83 nm. The tribological behavior is evaluated by foul-ball machine. It w...A novel fullerene-styrene-maleic anhydride copolymer is reported. TEM analyses shows it is water- soluble nanoball of average diameter of about 83 nm. The tribological behavior is evaluated by foul-ball machine. It was found that addition of fullerene copolymer to base stock (2%triethanolamine aqueous solution)resulted in a raise in load-carrying ability(F value)from 130 N to maximum 480 N, and a reduction in coefficient of friction from 0.235 to minimum 0. 063. SEM analyses indicates that the wear scare obtained with fullerene copolymer exhibited mild scratches, while sharp grooving and serious pull-out phenomnon were observed in the presence of base stock without additive .The improvements in friction, wear and load-carrying capacity are probably due to the presence of fullerene copolymer nanoballs, which may act as molecule ball bearings, which in turn lead to elastic rolling lubrication.展开更多
A novel Fullerene-ltaconic acid copolymer is synthesized via radical polymerization. It issoluble in polar solvents such as water, methanol, acetone and tetrahydrofuran etc.. The molecularstructure is identified and c...A novel Fullerene-ltaconic acid copolymer is synthesized via radical polymerization. It issoluble in polar solvents such as water, methanol, acetone and tetrahydrofuran etc.. The molecularstructure is identified and characterized by FTIR, UV-Vis and GPC. TEM analyses shows that itpresents an ideal spherical shape in water with an average diameter of about 48nm. Four-balltests show that the addition of a certain concentration of the Fullerene copolymer to the base stockcan effectively raise the load-carrying capacity (P_B Value) and the antiwear ability. JSM-35C modelscanning electron microscope (SEM) is used to examine the morphologies of the worn surfaces,which show that the additive results in a smaller wear scar diameter and a more shallow weargrooving.展开更多
A novel fullerene-acrylamide copolymer was synthesized via radical polymerization. It is soluble in polar sol- vents such as water, dimethyl sulfoxide etc. The product was characterized by FTIR, UV-Vis and GPC. TEM a...A novel fullerene-acrylamide copolymer was synthesized via radical polymerization. It is soluble in polar sol- vents such as water, dimethyl sulfoxide etc. The product was characterized by FTIR, UV-Vis and GPC. TEM analy- sis shows that the average particle diameter is about 46 nm. Four-ball tests show that the addition of a certain con- centration of the fullerene copolymer to base stock (2 wt% triethanolamine and 0.5 wt% OPZ aqueous solution) can effectively raise the load-carrying capacity (PB value) and the antiwear ability. SEM analysis shows that the addition results in reducing diameter of wear scar and decreasing wear.展开更多
文摘The aim of the present investigation was to develop a biosensor for the detection of amino acids, Leucine, Isoleucine and Valine based on a quartz crystal nanobalance. leucine (Leu), isoleucine (Ile), and valine (Val) were selectively determined by quartz crystal nanobalance (QCN) sensor in conjunction with net analyte signal (NAS)-based method called HLA/GO. An orthogonal design was applied for the formation of calibration and prediction sets including Leu, Ile and Val compounds. The selection of the optimal time range involved the calculation of the net analyte sig-nal regression plot in any considered time window for each test sample. The searching of a region with maximum linearity of NAS regression plot (minimum error indicator) and minimum of PRESS value was carried out by applying a moving window strategy. On the base of obtained results, the differences on the adsorption profiles in the time range between 1 and 300 s were used to determine mixtures of compounds by HLA/GO method. The results showed that the method was successfully applied for the determina-tion of Leu, Ile and Val.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.91834301,21606027,and 21436003).
文摘The Chinese iron pan can function as a nonstick pan even without a polytetrafluoroethylene(PTFE)coating after a“Kitchen God blessing”seasoning process.We simulate this process and disclose the science behind the“Kitchen God blessing,”finding that through repeated oil-coating and heating,the reversible insertion and extraction of oxygen atoms split the surface of the iron pan,gradually producing Fe 3 O 4 nanoballs.These balls give the iron pan a conditional hydrophobicity property,meaning the pan would be hydrophilic when the ingredients contain much water and hydrophobic when they contain less water.The former enables heat to be transferred rapidly through the nanoballs while the latter slows down the heat transference and prevents the pan from sticking.This discovery provides an approach of generating nanoballs on the surface of the metal and also discloses the secret of the fantastic taste produced by cooking with a Chinese iron pan.
基金supported by National Research Foundation of Korea(NRF) grants funded by the Korea Government(MSIP)a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI) funded by the Ministry of Health&Welfare,Republic of Korea(HI16C1501)+1 种基金a grant from the Medical Cluster R&D Support Project through the Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF) funded by the Ministry of Health and Welfare(HT16C0001,HT16C0002,HT17C0009)a National Research Foundation of Korea(NRF) Grant funded by the Korea Government(MSIP)(2014R1A1A1003323,2017R1D1A1B03028340,2018R1D1AB07047417)
文摘Plasmonic nanostructure-mediated photothermal therapy(PTT) has proven to be a promising approach for cancer treatment,and new approaches for its effective delivery to tumor lesions are currently being developed.This study aimed to assess macrophage-mediated delivery of PTT using radioiodine-124-labeled gold nanoparticles with crushed gold shells(124I-Au@AuCBs) as a theranostic nanoplatform.124I-Au@AuCBs exhibited effective photothermal conversion effects both in vitro and in vivo and were efficiently taken up by macrophages without cytotoxicity.After the administration of 124I-Au@AuCB-labeled macrophages to colon tumors,intensive signals were observed at tumor lesions,and subsequent in vivo PTT with laser irradiation yielded potent antitumor effects.The results indicate the considerable potential of 124I-Au@AuCBs as novel theranostic nanomaterials and the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases.
基金This project is supported by National Natural Science Foundation of China (29674010) and State Key Lab of Plastic Forming Simula
文摘A novel fullerene-styrene-maleic anhydride copolymer is reported. TEM analyses shows it is water- soluble nanoball of average diameter of about 83 nm. The tribological behavior is evaluated by foul-ball machine. It was found that addition of fullerene copolymer to base stock (2%triethanolamine aqueous solution)resulted in a raise in load-carrying ability(F value)from 130 N to maximum 480 N, and a reduction in coefficient of friction from 0.235 to minimum 0. 063. SEM analyses indicates that the wear scare obtained with fullerene copolymer exhibited mild scratches, while sharp grooving and serious pull-out phenomnon were observed in the presence of base stock without additive .The improvements in friction, wear and load-carrying capacity are probably due to the presence of fullerene copolymer nanoballs, which may act as molecule ball bearings, which in turn lead to elastic rolling lubrication.
文摘A novel Fullerene-ltaconic acid copolymer is synthesized via radical polymerization. It issoluble in polar solvents such as water, methanol, acetone and tetrahydrofuran etc.. The molecularstructure is identified and characterized by FTIR, UV-Vis and GPC. TEM analyses shows that itpresents an ideal spherical shape in water with an average diameter of about 48nm. Four-balltests show that the addition of a certain concentration of the Fullerene copolymer to the base stockcan effectively raise the load-carrying capacity (P_B Value) and the antiwear ability. JSM-35C modelscanning electron microscope (SEM) is used to examine the morphologies of the worn surfaces,which show that the additive results in a smaller wear scar diameter and a more shallow weargrooving.
基金Project supported by the National Natural Science Foundation of China (No. 20074012) and Anhui Provincial Universities Natural Science Founda-tion (No. 2002kj290).
文摘A novel fullerene-acrylamide copolymer was synthesized via radical polymerization. It is soluble in polar sol- vents such as water, dimethyl sulfoxide etc. The product was characterized by FTIR, UV-Vis and GPC. TEM analy- sis shows that the average particle diameter is about 46 nm. Four-ball tests show that the addition of a certain con- centration of the fullerene copolymer to base stock (2 wt% triethanolamine and 0.5 wt% OPZ aqueous solution) can effectively raise the load-carrying capacity (PB value) and the antiwear ability. SEM analysis shows that the addition results in reducing diameter of wear scar and decreasing wear.