Nanotechnologies Applied in Biomedical Vaccines

Vaccination, one of the most effective strategies to prevent infectious diseases, is the administration of antigenic materials to stimulate an individual＇s immune system to develop adaptive immunity to a specific pathogen. Though it is so advantageous for diseases control and prevention, vaccines still have some limitations. Nanotechnology is an approach to prepare a novel biomedicine-vaccine with the vaccine consumption and side effects significantly decreased. Regulation is the most important criterion for the development of nanovaccines. All marketing products have to meet the requirement of regulation. The fast track designation potentially aids in the development and expedites the review of nanovaccines that show promises in an unmet medical need. Here, some successful nanovaccine products are introduced---Inflexal^（R） V, Epaxal^（R）, Gardasil^TM and Cervarix^TM have been widely used for the clinical applications, which are delivered in the form of either virosomes or virus-like particles. Vaccines based on nanotechnology may overcome their original disadvantages and lead to the development of painless, safer and more effective products. In this study, nanotechnology is shown to be a good strategy to make a perfect vaccination system through advanced skills and strict regulation requirements.

Human Rights and Nanotechnologies： Limits and Possibilities Between Technological Innovation and Rights of the Human

Nanotechnology currently represents one of the most fascinating human discoveries. With creativity, nanotechnology looks for increasingly smaller spaces in nature to meet the needs and interests of the individuals and of the society. Considering that the researches aim to create techniques to move and combine atoms and molecules, a question arises, how will these atoms and molecules behave in the new arrangement. This is the great challenge and this article attempts to bring some benefits to the subiect. It also intends to bring the human sciences, particularly law, to the scenery of this scientific revolution. The lack of regulatory frameworks does not allow humans to search and produce anything without limits. Thus, human rights should be considered an ethical foundation for nanotechnology discoveries, as they represent the ＂rights＂ that, at least, humans should have respected.

Bridging bioengineering and nanotechnology: Bone marrow derived mesenchymal stem cell-exosome solutions for peripheral nerve injury

Peripheral nerve injury(PNI)is a common disease that is difficult to nerve regeneration with current therapies.Fortunately,Zou et al demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells(BMSCs)in promoting nerve regeneration,revealing broad prospects for BMSCs trans-plantation in alleviating PNI.We confirmed the fact that BMSCs significantly alleviate PNI,but there are shortcomings such as low cell survival rate and immune rejection,which limit the wide application of BMSCs.BMSCs-derived exosomes(Exos)are considered as a promising cell-free nanomedicine for PNI,avoiding the ethical issues of BMSCs.Exos in combination with bioengineering therapeutics(including extracellular matrix,hydrogel)brings new hope for PNI,provides a favorable microenvironment for neurological restoration and a therapeutic strategy with a favorable safety profile,significantly increases ex-pression of neurotrophic factors,promotes axonal and myelin regeneration,and demonstrates a strong potential to enhance neurogenesis.Therefore,engineered Exos exhibit better properties,such as stronger targeting and more beneficial components.This article briefly describes the role of nanotechnology and bioe-ngineering therapies for BMSCs in PNI,proposes clinical application prospects and challenges of nanotechnology and bioengineering BMSCs-derived Exos in PNI to improve the efficacy of BMSCs in the treatment of PNI.

Microbial resistance to nanotechnologies:An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants

Microbial resistance to current antibiotics therapies is a major cause of implant failure and adverse clinical outcomes in orthopaedic surgery.Recent developments in advanced antimicrobial nanotechnologies provide numerous opportunities to effective remove resistant bacteria and prevent resistance from occurring through unique mechanisms.With tunable physicochemical properties,nanomaterials can be designed to be bactericidal,antifouling,immunomodulating,and capable of delivering antibacterial compounds to the infection region with spatiotemporal accuracy.Despite its substantial advancement,an important,but under-explored area,is potential microbial resistance to nanomaterials and how this can impact the clinical use of antimicrobial nanotechnologies.This review aims to provide a better understanding of nanomaterial-associated microbial resistance to accelerate bench-to-bedside translations of emerging nanotechnologies for effective control of implant associated infections.

Magnetic nanotechnologies for early cancer diagnostics with liquid biopsies:a review

Liquid biopsy has become an emerging technology in the detection of cancer related biomarkers as well as the continuous monitoring of cancer treatment.There has been extensive research on the applications of magnetic nanotechnologies in liquid biopsies from the separation of target analytes to the detection of cancer biomarkers.Magnetic separation plays an important role in increasing both the efficiency and sensitivity of the liquid biopsy process.The detection of cancer biomarkers through magnetic nanosensors also possesses many advantages such as low background noise,high sensitivity,short assay time,and the ability to detect multiple biomarkers at the same time.This review focuses on the recent advances of magnetic nanotechnologies in liquid biopsies for cancer detection and its future potential in comparison with other technologies.

Application of nanotechnologies in the energy sector： A brief and short review

Energy is of great because of its benefits as the importance in human life main resource for human activity. According to International Energy Agency （IEA）, energy demands are expected to continue increasing until 2030. Because energy demand will never decrease, it is necessary to develop modem technology, such as nano-based technology, in order to obtain a more effective and efficient process to produce more energy. The application of nano technology or nano material in the field of energy, which involves lithium-ion battery, fuel cell, light emitting diode （LED）, ultra-capacitor, and solar cell （including Graitzel cell）, is a hot topic in many scientific researches. Unfortunately, its current development is hampered by the expensive cost of production compared to conventional technologies. Therefore, priority should be given to nano technology in the energy sector order to obtain higher efficiency, lower production cost, and easier in its application.

Nano/Micro-Structural Supramolecular Biopolymers: Innovative Networks with the Boundless Potential in Sustainable Agriculture

Sustainable agriculture plays a crucial role in meeting the growing global demand for food while minimizing adverse environmental impacts from the overuse of synthetic pesticides and conventional fertilizers.In this context,renewable biopolymers being more sustainable offer a viable solution to improve agricultural sustainability and production.Nano/micro-structural supramolecular biopolymers are among these innovative biopolymers that are much sought after for their unique features.These biomaterials have complex hierarchical structures,great stability,adjustable mechanical strength,stimuli-responsiveness,and self-healing attributes.Functional molecules may be added to their flexible structure,for enabling novel agricultural uses.This overview scrutinizes how nano/micro-structural supramolecular biopolymers may radically alter farming practices and solve lingering problems in agricultural sector namely improve agricultural production,soil health,and resource efficiency.Controlled bioactive ingredient released from biopolymers allows the tailored administration of agrochemicals,bioactive agents,and biostimulators as they enhance nutrient absorption,moisture retention,and root growth.Nano/micro-structural supramolecular biopolymers may protect crops by appending antimicrobials and biosensing entities while their eco-friendliness supports sustainable agriculture.Despite their potential,further studies are warranted to understand and optimize their usage in agricultural domain.This effort seeks to bridge the knowledge gap by investigating their applications,challenges,and future prospects in the agricultural sector.Through experimental investigations and theoretical modeling,this overview aims to provide valuable insights into the practical implementation and optimization of supramolecular biopolymers in sustainable agriculture,ultimately contributing to the development of innovative and eco-friendly solutions to enhance agricultural productivity while minimizing environmental impact.

Smart agriculture and nanotechnology:Technology,challenges,and new perspective

In the recent past,much nanotechnology research has been done in an effort to increase agricultural productivity.The Green Revolution led to the careless use of pesticides and artificial fertilizers,which reduced soil biodiversity and led to the development of disease and insect resistance.This article highlights the worldwide development and status of precision agriculture.Precision agriculture utilizes technologies and principles to manage spatial and temporal variability in agricultural production to improve crop performance and environmental quality.In precision agriculture(PA),information technology(IT)is used to make sure that crops and soil receive exactly what they require for optimal productivity and health.Precision farming includes the use of hardware i.e.,a global positioning system(GPS)and geographic information system(GIS),different software of GIS,and traditional knowledge of agriculture management practices.The benefits of precision agriculture can be seen in both the economic and environmental aspects of agricultural production.Only nanoparticles or nanochips can transport materials to plants in a nanoparticle-mediated manner and create sophisticated biosensors for precision farming.Conventional fertilizers,insecticides,and herbicides can be nano encapsulated to provide exact doses to plants through a gradual,continuous release of nutrients and agrochemicals.The main topics included in this article are the variability of natural resources,variability management;administrative districts;the impact of precision farming technologies on farm profitability and the environment;innovations in sensors,controls,and remote sensing,information management;trends in global application and acceptance of precision farming technologies;potential and possibilities of technology along with challenges in agricultural modernization.Modern equipment and procedures based on nanotechnology have the ability to solve many of the issues in conventional agriculture and might transform this industry.There are many challenges in the implementation of smart agriculture equipment and approaches in thefield as this technique uses both hardware and software.The cost of labour for managing IoT devices and the cost-of-service registration are included in the system operational cost.Additionally,there are operating costs related to the use of energy,maintenance,and communication between IoT devices,gateways,and cloud servers.In this review,nanotechnology is explored as a potential tool in precision agriculture,as well as the advantages of nanoparticles in agriculture,such as the use of fertilizers.By using precision agriculture,the food production chain can be monitored and quality and quantity can be managed effectively.

Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

As a new form of regulated cell death,ferroptosis has unraveled the unsolicited theory of intrinsic apoptosis resistance by cancer cells.The molecular mechanism of ferroptosis depends on the induction of oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage the structural integrity of cells.Due to their high loading and structural tunability,nanocarriers can escort the delivery of ferro-therapeutics to the desired site through enhanced permeation or retention effect or by active targeting.This review shed light on the necessity of iron in cancer cell growth and the fascinating features of ferroptosis in regulating the cell cycle and metastasis.Additionally,we discussed the effect of ferroptosis-mediated therapy using nanoplatforms and their chemical basis in overcoming the barriers to cancer therapy.

Metal-organic frameworks in oral drug delivery

Metal-organic frameworks(MOFs)offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination of metal ions and organic ligands.This review systematically examines the structural properties and principles of MOFs,setting the stage for their application in drug delivery.It discusses various classes of MOFs,including those based on zirconium,iron,zinc,copper,titanium,aluminum,potassium,and magnesium,assessing their drug-loading capacities,biocompatibility,and controlled release mechanisms.The effectiveness of MOFs is illustrated through case studies that highlight their capabilities in enhancing drug solubility,providing protection against the harsh gastrointestinal environment,and enabling precise drug release.The review addresses potential challenges,particularly the toxicity concerns associated with MOFs,and calls for further research into their biocompatibility and interactions with biological systems.It concludes by emphasizing the potential of MOFs in revolutionizing oral drug delivery,highlighting the critical need for comprehensive research to harness their full potential in clinical applications.

Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

Cancer is a leading cause of death globally,with limited treatment options and several limitations.Chemotherapeutic agents often result in toxicity which long-term conventional treatment.Phytochemicals are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the resistance.These phytoconstituents act in several ways and deliver optimum effectiveness against cancer.Nevertheless,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and stability.Nanotechnology presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective effects.This holds significant potential for future advancements in cancer management.Herein,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in cancer.Moreover,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo settings.Lastly,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

Impact of nanoparticles on immune cells and their potential applications in cancer immunotherapy

Nanoparticles represent a heterogeneous collection of materials,whether natural or synthetic,with dimensions aligning in the nanoscale.Because of their intense manifestation with the immune system,they can be harvested for numerous bio-medical and biotechnological advancements mainly in cancer treatment.This review article aims to scrutinize various types of nanoparticles that interact differently with immune cells like macrophages,dendritic cells,T lymphocytes,and natural killer(NK)cells.It also underscores the importance of knowing how nanoparticles influence immune cell functions,such as the production of cytokines and the presentation of antigens which are crucial for effective cancer immunotherapy.Hence overviews of bio-molecular mechanisms are provided.Nanoparticles can improve antigen presentation,boost T-cell responses,and overcome the immunosuppressive tumor environment.The regulatory mechanisms,signaling pathways,and nanoparticle characteristics are also presented for a comprehensive understanding.We review the nanotechnology platform options and challenges in nanoparticlesbased immunotherapy,from an immunotherapy perspective including precise targeting,immune modulation,and potential toxicity,as well as personalized approaches based on individual patient and tumor characteristics.The development of emerging multifunctional nanoparticles and theranostic nanoparticles will provide new solutions for the precision and efficiency of cancer therapies in next-generation practice.

Exploring Metal Based Nanoparticles for Boosting Plant Tolerance to Heavy Metals and Trace Element Contamination

Heavy metal pollution in agricultural soils is a significant challenge for global food production and human health with the increasing industrialization and urbanization.There is a concern about introducing innovative techni-ques that are eco-friendly,cost-effective,and have the potential to alleviate metals,enhance crop growth,and pro-tect plants against various environmental threats.For this,nanotechnology is one of the promising solutions having various applications in almost everyfield of life.This review explores various nano-based strategies that use nanoparticles(NPs)to lessen the harmful effects that heavy metals have on plants.Incorporated literature including published research and review papers from the year 2015 to 2023.This review paper gives a thorough review of the current situation regarding heavy metal contamination in agricultural soils and how it affects plant health.The necessity offinding practical and eco-friendly ways to address these issues is emphasized,paving the way for the introduction of NPs.Then,it highlighted the mechanistic route of heavy metal toxicity alleviation in plants by their application as well as their long-term efficiency and prospects.This review also elaborated on var-ious synthesis methods(physical,chemical,and green),but the emphasis on the green synthesis of NPs by utiliz-ing plant extract offers dependable and sustainable benefits over traditional physicochemical techniques.Under trace element stress,NPs application enhances plant antioxidant defense system,ameliorating structural changes,immobilizing trace elements in growth media,and improving the physio-chemical properties of soil as well.How-ever,there are still numerous limitations present on how these materials are synthesized,applied,and appropri-ately absorbed by plant cells.It is recommended to promote and fund long-term research to assess the long-term effects of using NPs on plant development,soil health,and possible environmental repercussions.

Orthopedic revolution:The emerging role of nanotechnology

This review summarizes the latest progress in orthopedic nanotechnology,ex-plores innovative applications of nanofibers in tendon repair,and evaluates the potential of selenium and cerium oxide nanoparticles in osteoarthritis and osteo-blast differentiation.This review also describes the emerging applications of inje-ctable hydrogels in cartilage engineering,emphasizing the critical role of inter-disciplinary research and highlighting the challenges and future prospects of in-tegrating nanotechnology into orthopedic clinical practice.This comprehensive approach provides a holistic perspective on the transformative impact of nanote-chnology in orthopedics,offering valuable insights for future research and clinical applications.

Nanotechnology in Nuclear Reactors: Innovations in Fusion and Fission Power Generation

This article explores the transformative potential of nanotechnology and MMs(memory metals)in enhancing the design and operation of nuclear reactors,encompassing both fission and fusion technologies.Nanotechnology,with its ability to engineer materials at the atomic scale,offers significant improvements in reactor safety,efficiency,and longevity.In fission reactors,nanomaterials enhance fuel rod integrity,optimize thermal management,and improve in-core instrumentation.Fusion reactors benefit from nanostructured materials that bolster containment and heat dissipation,addressing critical challenges in sustaining fusion reactions.The integration of SMAs(shape memory alloys),or MMs,further amplifies these advancements.These materials,characterized by their ability to revert to a pre-defined shape under thermal conditions,provide self-healing capabilities,adaptive structural components,and enhanced magnetic confinement.The synergy between nanotechnology and MMs represents a paradigm shift in nuclear reactor technology,promising a future of cleaner,more efficient,and safer nuclear energy production.This innovative approach positions the nuclear industry to meet the growing global energy demand while addressing environmental and safety concerns.

Rapid Green Synthesis of Silver Nanoparticles by Reishi and Their Antibacterial Activity and Mechanisms

Nanotechnology is a rapidly growing field in biomedical engineering with references to efficiency, safety, and cost-effective approaches. Herein, the objective of this study was to examine an innovative approach to rapidly synthesis silver nanoparticles from an aqueous extract of medicinal mushroom Ganoderma lucidum (also known as reishi). The structural and dimensional dispersion of the biosynthesized silver nanoparticles from reishi was confirmed by UV-Vis spectrophotometer (UV-Vis) and Scanning Electron Microscopy (SEM) analysis. Additionally, the biosynthesized silver nanoparticles from resihi were used to explore their potential antimicrobial activity against Staphylococcus aureus and Micrococcus luteus and Escherichia coli and Klebsiella pneumoniae. The results from this study revealed that the silver nanoparticles mediated by reishi adopted a spherical shape morphology with sizes, less than 100 nm and revealed strong absorption plasmon band at 440 nm. Furthermore, the biosynthesized silver nanoparticles from reishi exhibited antibacterial activity against the tested S. aureus and M. luteus and E. coli and K. pneumoniae by altering their morphology which signifies their biomedical potential.

Betamethasone Dipropionate Loaded in Nanoliposomes vs Conventional Betamethasone Dipropionate: Comparative Study of Permeability and Penetrability in Vitro and ex Vivo

A betamethasone dipropionate (BD) liposomal cream was developed to treat rheumatological, inflammatory, allergic diseases and psoriasis. BD is a corticosteroid, anti-inflammatory, and immunosuppressant. However, adverse effects are associated with prolonged topical use. For this reason, liposomes were loaded with BD because they offer excellent biocompatibility, bio adhesiveness, and penetrability that improve the effects caused by the conventional drug. Liposomal dispersions were prepared by emulsification using phospholipid 90 (lipid) and Tween 80 (surfactant). The particle size, polydispersity index (PDI), and zeta potential were measured using a particle analyzer. The betamethasone (BM) percentage of encapsulated active (EA) ingredient was also determined through High Performance Liquid Chromatography (HPLC). The Franz cell and tape stripping characterized these in vitro and ex vivo. Then the final formulation reached a particle size of 70.80 ± 3.31 nm, a PDI of 0.242 ± 0.038, a zeta potential of −11.68 ± 0.77 mv and encapsulate active of 83.1% ± 2.4, complying with the parameters of a nanotechnological formulation. In vitro and ex vivo studies confirmed significantly efficacy of the cream over the commercial product, through the greater penetration into the pig ear skin, resulting in an improved drug. Finally, the liposomal cream demonstrated significant potential for enhanced percutaneous absorption, attributed to its nanometric size. This innovative nanotechnology approach aims to reduce the frequency of topical applications, thereby minimizing the side effects associated with psoriasis treatment.

Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

In accordance with the World Health Organization data,cancer remains at the forefront of fatal diseases.An upward trend in cancer incidence and mortality has been observed globally,emphasizing that efforts in developing detection and treatment methods should continue.The diagnostic path typically begins with learning the medical history of a patient;this is followed by basic blood tests and imaging tests to indicate where cancer may be located to schedule a needle biopsy.Prompt initiation of diagnosis is crucial since delayed cancer detection entails higher costs of treatment and hospitalization.Thus,there is a need for novel cancer detection methods such as liquid biopsy,elastography,synthetic biosensors,fluorescence imaging,and reflectance confocal microscopy.Conventional therapeutic methods,although still common in clinical practice,pose many limitations and are unsatisfactory.Nowadays,there is a dynamic advancement of clinical research and the development of more precise and effective methods such as oncolytic virotherapy,exosome-based therapy,nanotechnology,dendritic cells,chimeric antigen receptors,immune checkpoint inhibitors,natural product-based therapy,tumor-treating fields,and photodynamic therapy.The present paper compares available data on conventional and modern methods of cancer detection and therapy to facilitate an understanding of this rapidly advancing field and its future directions.As evidenced,modern methods are not without drawbacks;there is still a need to develop new detection strategies and therapeutic approaches to improve sensitivity,specificity,safety,and efficacy.Nevertheless,an appropriate route has been taken,as confirmed by the approval of some modern methods by the Food and Drug Administration.

Nano-controlled release of phytohormones will broaden its application on plant protection

Phytohormone is a key regulator of plant growth and development.It has important effects on plant under biotic and abiotic stresses.However,the dose control of phytohormone is always a difficult problem in the application process,which limits the application range of phytohormone.Nanotechnology,because of its characteristics of controlled release,targeted therapy,non-pollution,high adsorption,lower volatilization of active substances,and low dosage of drug,comes into researchers’vision.Nanomaterials were directly applicated on crops at the early stage,and then active substances,such as pesticides,were encapsulated with nanomaterials,also achieved good results in the field.Currently,more and more attentions have been paid to nano-enabled delivery of phytohormones to plants,and formed a new field in agriculture.In present work,we reviewed the existing literatures,focused on the important regulatory roles of phytohormones in plant growth and development and their application potential,and the development and application prospect of nanomaterials combined with phytohormones were also have been discussed.

Research Progress of Solid Hydrogen Storage Materials for Hydrogen Energy Storage and Transportation

With the rapid development of hydrogen energy, hydrogen storage alloys have attracted wide attention owing to their key advantages, such as high volume density, proper plateau pressure, environmental friendliness and good safety. In the present review, the research progress of the improvement in hydrogen storage alloys, including rare-earth-based alloys, Mg-based alloys, Ti/Zr-based alloys, V-based alloys and high entropy alloys are systematically summarized. The influences of elemental substitution, catalyst doping, preparation methods and nanotechnology on the crystal structure, hydrogen storage properties as well as their affecting mechanisms, are discussed. Furthermore, the development trend and future research directions are proposed, which are expected to bring novel research ideas and potentially applicable methods for the development of high-performance hydrogen storage alloys.