Four hitherto unknown aristolane-type sesquiterpenes,including one novel 8,9-secoaristolane,namely secoaristolenedioic acid(1),two aristolone derivatives,namely 1α,2β-dihydroxyaristolone(2),9-epidebilon(3),and one r...Four hitherto unknown aristolane-type sesquiterpenes,including one novel 8,9-secoaristolane,namely secoaristolenedioic acid(1),two aristolone derivatives,namely 1α,2β-dihydroxyaristolone(2),9-epidebilon(3),and one rare aristolane-chalcone hybrid,namely 3′-hydroxynardoaristolone A(4)were isolated from the ethanol extract of the roots and rhizomes of Nardostachys chinensis.Their structures were elucidated on the basis of extensive spectroscopic analysis.In addition,the structure of aristolanhydride,recently isolated from the same species,was corrected by reanalysis of the published NMR data.展开更多
目的探讨甘松不同提取成分对大鼠急性胃炎的预防作用,为临床用药提供依据。方法将W istar大鼠完全随机分成生理盐水组、甘松水提浸膏高剂量组、甘松水提浸膏高剂量加挥发油高剂量组、甘松水提浸膏高剂量与挥发油低剂量组、甘松水提浸膏...目的探讨甘松不同提取成分对大鼠急性胃炎的预防作用,为临床用药提供依据。方法将W istar大鼠完全随机分成生理盐水组、甘松水提浸膏高剂量组、甘松水提浸膏高剂量加挥发油高剂量组、甘松水提浸膏高剂量与挥发油低剂量组、甘松水提浸膏低剂量与挥发油低剂量组及西咪替丁对照组,连续5天,1次/天灌胃给药,末次给药后90分钟,所有动物均灌胃予95%乙醇1 m l只/,观察各药物组预防乙醇所致大鼠急性胃炎及胃溃疡的作用。结果甘松水提浸膏高剂量组、甘松水提浸膏高剂量加挥发油高剂量组、甘松水提浸膏高剂量与挥发油低剂量组、甘松水提浸膏低剂量与挥发油低剂量组在减少胃炎发生方面优于生理盐水组及西咪替丁对照组,其构成比之间差异具有显著的统计学意义(P<0.01);甘松水提浸膏高剂量组、甘松水提浸膏高剂量加挥发油高剂量组、甘松水提浸膏高剂量与挥发油低剂量组的溃疡抑制率分别为37.11%、95.06%、78.38%,高于西咪替丁对照组(35.99%),差异有统计学意义(P<0.05)。结论甘松不同提取成份组合给药对预防急性胃炎及抑制胃溃疡有明显的作用。展开更多
基金supported by the“Large-scale Compound Library”project of National Development and Reform Commission of China.
文摘Four hitherto unknown aristolane-type sesquiterpenes,including one novel 8,9-secoaristolane,namely secoaristolenedioic acid(1),two aristolone derivatives,namely 1α,2β-dihydroxyaristolone(2),9-epidebilon(3),and one rare aristolane-chalcone hybrid,namely 3′-hydroxynardoaristolone A(4)were isolated from the ethanol extract of the roots and rhizomes of Nardostachys chinensis.Their structures were elucidated on the basis of extensive spectroscopic analysis.In addition,the structure of aristolanhydride,recently isolated from the same species,was corrected by reanalysis of the published NMR data.
文摘目的探讨甘松不同提取成分对大鼠急性胃炎的预防作用,为临床用药提供依据。方法将W istar大鼠完全随机分成生理盐水组、甘松水提浸膏高剂量组、甘松水提浸膏高剂量加挥发油高剂量组、甘松水提浸膏高剂量与挥发油低剂量组、甘松水提浸膏低剂量与挥发油低剂量组及西咪替丁对照组,连续5天,1次/天灌胃给药,末次给药后90分钟,所有动物均灌胃予95%乙醇1 m l只/,观察各药物组预防乙醇所致大鼠急性胃炎及胃溃疡的作用。结果甘松水提浸膏高剂量组、甘松水提浸膏高剂量加挥发油高剂量组、甘松水提浸膏高剂量与挥发油低剂量组、甘松水提浸膏低剂量与挥发油低剂量组在减少胃炎发生方面优于生理盐水组及西咪替丁对照组,其构成比之间差异具有显著的统计学意义(P<0.01);甘松水提浸膏高剂量组、甘松水提浸膏高剂量加挥发油高剂量组、甘松水提浸膏高剂量与挥发油低剂量组的溃疡抑制率分别为37.11%、95.06%、78.38%,高于西咪替丁对照组(35.99%),差异有统计学意义(P<0.05)。结论甘松不同提取成份组合给药对预防急性胃炎及抑制胃溃疡有明显的作用。
