Analysis of 80 Cases of Nasopharyngeal Carcinoma Treated by Intracavitary Brachytherapy Using A New-Type Applicator

OBJECTIVE To evaluate the results and complications associated with nasopharyngeal carcinoma (NPC) treated with combined external-beam radiotherapy (EBR) and intracavitary brachytherapy (IB) using a new-type applicator. METHODS Eighty patients with untreated NPC were divided into two groups based on therapy methods. An experimental group was treated with EBR plus IB and a control group was treated only with EBR. IB was given to the patients of the experimental group when the external radiotherapy dose amounted to more than 60～65 Gy. The total dose of IB was 6～20 Gy and the total dose of EBR of the control group was 70～75 Gy. RESULTS Follow-up was conducted for 97.5% of the patients with results as follows: the overall response rates (ORR) for the experimental and the control groups were 92.5% and 75.3% respectively (P<0.05); the 3 and 5-year survival rates for the experimental group were 87.5% and 74.2% and for the control group, 65.0% and 55.6% (P<0.05); for the experimental group, the 3 and 5-year disease-free survival rates were 72.5% and 64.5% and for the control group, 60.0% and 52.8% (P>0.05).Some complications following radiotherapy showed a signi fi cant difference. CONCLUSION External irradiation plus intracavitary brachytherapy using a new-type applicator may improve the ORR and survival rates, reduce radiation complications and increase the quality of life.

80例鼻咽癌应用新型施源器腔内后装治疗的疗效分析

目的:探讨鼻咽癌外照射联合新型施源器后装治疗与单纯外照射的疗效和并发症。方法:将80例初治鼻咽癌患者按治疗方法分为外照射联合腔内后装(综合治疗组)及单纯外照射(对照组)两组,综合治疗组外照射剂量DT60～65Gy,腔内后装在外照射后期进行,剂量DT6～20Gy,中位剂量12Gy。对照组外照射剂量DT70～75Gy。结果:全部病例随访至2006年5月,随访率97.5%,综合治疗组和对照组的近期有效率分别为92.5%、75.3%(P<0.05),3、5年生存率分别为87.5%、65.0%(P<0.05)及74.2%、55.6%(P>0.05);3、5年无瘤生存率分别为72.5%、60.0%及64.5%、52.8%(P>0.05)。两组并发症发生率有显著性差异。结论:鼻咽癌外照射联合新型施源器后装治疗提高肿瘤近期有效率和3、5年生存率,降低口咽干燥等放疗并发症发生,提高生活质量。

鼻咽癌不同方式放疗疗效分析

目的 分析比较鼻咽癌不同放疗方式的疗效。方法 回顾性分析1997年1月～2002年1月220例鼻咽癌初治患者临床资料。分别采用常规外照射放疗、体外照射联合腔内放疗、三维适形放疗治疗。常规外照射放疗患者72例，接受70～78Gy的根治放疗；体外照射联合腔内放疗92例，外照射60～65Gy（咽旁间隙浸润者予以65～70Gy），腔内放疗总剂量为8～22Gy，分1～3次，于1～3周完成；三维适形放疗56例，外照射40Gy后加三维适形放疗，剂量30～40Cy。统计分析各组3年生存率、3年局部控制率及并发症发生率，并比较其差异。结果 常规放疗组3年生存率、3年局部控制率为81．9％、77．8％；体外照射联合腔内放疗组及三维适形放疗组分别为80．9％、84、0％及78．6％、80．4％，组间比较差异无统计学意义（P〉0．05）；体外照射联合腔内放疗组及三维适形放疗组的各种并发症发生率明显低于常规放疗组（P〈0．05），而前两组间无明显差异（P〉0．05）。结论 三种方式放疗治疗鼻咽癌疗效无明显差异，但腔内放疗、三维适形放疗相对外照射剂量降低，减轻了正常组织器官的放射损伤，从而减少了放疗并发症的发生。