OBJECTIVE To evaluate the results and complications associated with nasopharyngeal carcinoma （NPC） treated with combined external-beam radiotherapy （EBR） and intracavitary brachytherapy （IB） using a new-type app...OBJECTIVE To evaluate the results and complications associated with nasopharyngeal carcinoma （NPC） treated with combined external-beam radiotherapy （EBR） and intracavitary brachytherapy （IB） using a new-type applicator. METHODS Eighty patients with untreated NPC were divided into two groups based on therapy methods. An experimental group was treated with EBR plus IB and a control group was treated only with EBR. IB was given to the patients of the experimental group when the external radiotherapy dose amounted to more than 60～65 Gy. The total dose of IB was 6～20 Gy and the total dose of EBR of the control group was 70～75 Gy. RESULTS Follow-up was conducted for 97.5% of the patients with re- suits as follows： the overall response rates （ORR） for the experimental and the control groups were 92.5% and 75.3% respectively （P〈0.05）; the 3 and 5-year survival rates for the experimental group were 87.5% and 74.2% and for the control group, 65.0% and 55.6% （P〈0.05）; for the experimental group, the 3 and 5-year disease-free survival rates were 72.5% and 64.5% and for the control group, 60.0% and 52.8% （P〉0.05）.Some complications following radiotherapy showed a significant difference. CONCLUSION External irradiation plus intracavitary brachytherapy using a new-type applicator may improve the ORR and survival rates, reduce radiation complications and increase the quality of life. 展开更多
Objective: To evaluate the effect of brachytherapy intracavitary residual tumor on patients with NPC after radiation therapy Methods: Five hundred sixty three NPC with residual tumor in the nasopharynx were treated ...Objective: To evaluate the effect of brachytherapy intracavitary residual tumor on patients with NPC after radiation therapy Methods: Five hundred sixty three NPC with residual tumor in the nasopharynx were treated with large dose of brachytherapy (2025 Gy) The treatment results were retropectively evaluated Results: Within 3 months after brachytherapy, the overall regression rate of the residual tumor was 90 4% Upon long term follow up, the 1 , 3 and 5 year survival rate was 89 65%, 67 01% and 55 42%, respectively The major complications of the after loading treatment were nasal obstruction (16 2%), necrosis of the nasopharynx (0 9%) and perforation of soft foliate in 2 patients Conclusion Brachytherapy is effective in the treatment of residual NPC especially in patients in early stage It may not be helpful to stage IV patients展开更多
文摘OBJECTIVE To evaluate the results and complications associated with nasopharyngeal carcinoma （NPC） treated with combined external-beam radiotherapy （EBR） and intracavitary brachytherapy （IB） using a new-type applicator. METHODS Eighty patients with untreated NPC were divided into two groups based on therapy methods. An experimental group was treated with EBR plus IB and a control group was treated only with EBR. IB was given to the patients of the experimental group when the external radiotherapy dose amounted to more than 60～65 Gy. The total dose of IB was 6～20 Gy and the total dose of EBR of the control group was 70～75 Gy. RESULTS Follow-up was conducted for 97.5% of the patients with re- suits as follows： the overall response rates （ORR） for the experimental and the control groups were 92.5% and 75.3% respectively （P〈0.05）; the 3 and 5-year survival rates for the experimental group were 87.5% and 74.2% and for the control group, 65.0% and 55.6% （P〈0.05）; for the experimental group, the 3 and 5-year disease-free survival rates were 72.5% and 64.5% and for the control group, 60.0% and 52.8% （P〉0.05）.Some complications following radiotherapy showed a significant difference. CONCLUSION External irradiation plus intracavitary brachytherapy using a new-type applicator may improve the ORR and survival rates, reduce radiation complications and increase the quality of life.
文摘Objective: To evaluate the effect of brachytherapy intracavitary residual tumor on patients with NPC after radiation therapy Methods: Five hundred sixty three NPC with residual tumor in the nasopharynx were treated with large dose of brachytherapy (2025 Gy) The treatment results were retropectively evaluated Results: Within 3 months after brachytherapy, the overall regression rate of the residual tumor was 90 4% Upon long term follow up, the 1 , 3 and 5 year survival rate was 89 65%, 67 01% and 55 42%, respectively The major complications of the after loading treatment were nasal obstruction (16 2%), necrosis of the nasopharynx (0 9%) and perforation of soft foliate in 2 patients Conclusion Brachytherapy is effective in the treatment of residual NPC especially in patients in early stage It may not be helpful to stage IV patients
