期刊文献+
共找到1,275篇文章
< 1 2 64 >
每页显示 20 50 100
Smith-Purcell free electron laser based on the semi-elliptical resonator 被引量:7
1
作者 孟现柱 王明红 任忠民 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第5期215-221,共7页
A novel Smith-Purcell (S-P) free electron laser composed of an electron gun, a semi-elliptical resonator, a metallic reflecting grating and a collector, is presented for the first time. This paper studies the charac... A novel Smith-Purcell (S-P) free electron laser composed of an electron gun, a semi-elliptical resonator, a metallic reflecting grating and a collector, is presented for the first time. This paper studies the characteristics of this device by theoretical analysis and particle-in-cell simulation method. Results indicate that tunable coherent S-P radiation with a high output peak power at millimeter wavelengths can be generated by adjusting the length of the grating period, or adjusting the voltage of the electron beam. The present scheme has the following advantages: the semi-elliptical resonator can reflect all radiation with the emission angle {? and random azimuthal angles, back onto the electron beam with same-phase and causes the electrons to be modulated, so the output power and efficiency are improved. 展开更多
关键词 Smith-Purcell radiation free electron laser quasi optical resonator
下载PDF
High-speed directly modulated distributed feedback laser based on detuned loading and photon-photon resonance effect
2
作者 张云山 徐逸帆 +3 位作者 郑吉林 李连艳 方涛 陈向飞 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第9期274-281,共8页
A monolithic integrated two-section distributed feedback(TS-DFB)semiconductor laser for high-speed direct modulation is proposed and analyzed theoretically.The grating structure of the TS-DFB laser is designed by the ... A monolithic integrated two-section distributed feedback(TS-DFB)semiconductor laser for high-speed direct modulation is proposed and analyzed theoretically.The grating structure of the TS-DFB laser is designed by the reconstructionequivalent-chirp(REC)technique,which can reduce the manufacturing cost and difficulty,and achieve high wavelength controlling accuracy.The detuned loading effect and the photon-photon resonance(PPR)effect are utilized to enhance the modulation bandwidth of the TS-DFB laser,exceeding 37 GHz,while that of the conventional one-section DFB laser is only 16 GHz.When the bit rate of the non-return-to-zero(NRZ)signal reaches 55 Gb/s,a clear eye diagram with large opening can still be obtained.These results show that the proposed method can enhance the modulation bandwidth of DFB laser significantly. 展开更多
关键词 directly modulated laser(DML) detuned loading effect photon-photon resonance(PPR)effect reconstruction-equivalent-chirp(REC)technique
下载PDF
Comparison of Mode Quality Factors for Equilateral Triangular, Square and Rhombus Optical Micro-Resonators
3
作者 黄永箴 国伟华 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2001年第2期117-120,共4页
The mode frequencies and the quality factors for the equilateral triangular resonator (ETR), the square resonator (SR) and the rhombus resonator (RR) are numerically calculated by the finite difference time domai... The mode frequencies and the quality factors for the equilateral triangular resonator (ETR), the square resonator (SR) and the rhombus resonator (RR) are numerically calculated by the finite difference time domain technique and the Padé approximation. The numerical results show that the resonant modes confined in an equilateral triangular cavity have much higher quality factors than those in the square or the rhombus cavities. The modes in the ETR are totally confined in transverse direction while those in the SR and RR are only partly confined. For the ETR with the side length of 4μm and the refractive index of 3 2, the mode quality factor of about 5 5×10 3 at the wavelength of 1 55μm has been obtained. 展开更多
关键词 MICROresonator quality factor resonant frequency finite difference time domain technique semiconductor laser
下载PDF
Effect of unstable resonator stability on laser beam quality
4
作者 LIANG Xiaolin BAO Ben'gang +1 位作者 ZHOU Songqing CHEN Huihuang 《Optoelectronics Letters》 EI 2024年第9期523-530,共8页
In order to explore the effect of unstable resonator stability on laser beam quality,the numerical simulation of midinfrared laser and visible laser was carried out in GLAD software.The simulation results showed that ... In order to explore the effect of unstable resonator stability on laser beam quality,the numerical simulation of midinfrared laser and visible laser was carried out in GLAD software.The simulation results showed that the existence of defocus aberration,tilt aberration and astigmatic aberration in the unstable resonator can cause the center of the far-field spot of the output annular beam to drift,the number of peripheral diffraction rings to increase,the beam quality to deteriorate,and the degree of effect is different. 展开更多
关键词 resonator laser BEAM
原文传递
2.32W anti-misaligned Er:LuAG single-longitudinal-mode laser in the double corner-cube-retroreflector resonator and MOPA system
5
作者 范佳玮 鞠有伦 +7 位作者 姜辰晨 袁越 闫东 杨星帮 段小明 戴通宇 姚宝权 吴佳泽 《Chinese Optics Letters》 SCIE EI CAS CSCD 2024年第2期114-119,共6页
We demonstrate a high power,Er:Lu AG single-longitudinal-mode laser in an anti-misaligned resonator.Based on the Faraday effect,a 1.61 W single-longitudinal-mode(SLM)laser is obtained with the double corner-cube-retro... We demonstrate a high power,Er:Lu AG single-longitudinal-mode laser in an anti-misaligned resonator.Based on the Faraday effect,a 1.61 W single-longitudinal-mode(SLM)laser is obtained with the double corner-cube-retroreflector(CCR)structure,and the tunable wavelength is 1649.2-1650.3 nm.Additionally,we investigate the anti-misalignment characteristics when the CCR moves and rotates along the optical axis.Furthermore,by utilizing the Er:Lu AG amplifier,the maximum 2.32 W single-longitudinal-mode laser at 1649.6 nm is achieved.The beam quality factors M^(2) of the 2.32 W Er:Lu AG single-longitudinal-mode laser are 1.23 and 1.25 along the horizontal(x)and vertical(y)directions,respectively. 展开更多
关键词 Er:Lu AG single-longitudinal-mode laser Faraday effect MOPA system double corner-cube-retroreflector resonator
原文传递
Power output correction model of narrow linewidth ring fiber laser filtered with whispering gallery mode resonator
6
作者 王子云 徐在斌 +1 位作者 崔继文 谭久彬 《Chinese Optics Letters》 SCIE EI CAS CSCD 2024年第3期60-64,共5页
A whispering gallery mode resonator(WGMR)filter can narrow laser linewidth while significantly changing the output power characteristics of fiber laser system.It is found that traditional laser output power model is i... A whispering gallery mode resonator(WGMR)filter can narrow laser linewidth while significantly changing the output power characteristics of fiber laser system.It is found that traditional laser output power model is invalid.We report a correction model of a narrow linewidth fiber laser filtered with a WGMR to analyze its power.We believe that the loss of the laser system and the threshold gain increase caused by the WGMR filter lead to the predominate amplified spontaneous emission during the original laser period.According to that,we assume the correction coefficient is an exponential decay related to the Er-doped fiber length in the large loss situation,and we verify it experimentally.As a result,the correction model is valid for WGMR-filtered fiber laser. 展开更多
关键词 whispering gallery resonator filter narrow linewidth fiber laser power output correction model
原文传递
Real time detection of antibody-antigen interaction using a laser scanning confocal imaging-surface plasmon resonance system 被引量:4
7
作者 Zhang Hong-Yan Yang Li-Quan +5 位作者 Meng Lan Nie Jia-Cai Ning Ting-Yin Liu Wei-Min Sun Jia-Yu Wang Peng-Fei 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第2期224-228,共5页
A laser scanning confocal imaging-surface plasmon resonance (LSCI-SPR) instrument integrated with a wavelength-dependent surface plasmon resonance (SPR) sensor and a laser scanning confocal microscopy (LSCM) is ... A laser scanning confocal imaging-surface plasmon resonance (LSCI-SPR) instrument integrated with a wavelength-dependent surface plasmon resonance (SPR) sensor and a laser scanning confocal microscopy (LSCM) is built to detect the bonding process of human IgG and fluorescent-labeled affinity purified antibodies in real time. The shifts of resonant wavelength at different reaction time stages are obtained by SPR, corresponding well with the changes of the fluorescence intensity collected by using LSCM. The instrument shows the merits of the combination and complementation of the SPR and LSCM, with such advantages as quantificational analysis, high spatial resolution and real time monitor, which are of great importance for practical applications in biosensor and life science. 展开更多
关键词 laser scanning confocal imaging-surface plasmon resonance COMBINATION COMPLEMENTATION real time
下载PDF
Low noise,continuous-wave single-frequency 1.5-μm laser generated by a singly resonant optical parametric oscillator 被引量:3
8
作者 刘建丽 刘勤 +2 位作者 李宏 李鹏 张宽收 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第11期312-316,共5页
We report a low noise continuous-wave (CW) single-frequency 1.5-μm laser source obtained by a singly resonant optical parametric oscillator (SRO) based on periodically poled lithium niobate (PPLN). The SRO was ... We report a low noise continuous-wave (CW) single-frequency 1.5-μm laser source obtained by a singly resonant optical parametric oscillator (SRO) based on periodically poled lithium niobate (PPLN). The SRO was pumped by a CW single-frequency Nd:YVO4 laser at 1.06μm. The 1.02 W of CW single-frequency signal laser at 1.5 μm was obtained at pump power of 6 W. At the output power of around 0.75 W, the power stability was better than ±l.5% and no mode-hopping was observed in 30 min and frequency stability was better than 8.5 MHz in 1 min. The signal wavelength could be tuned from 1.57 to 1.59 μm by varying the PPLN temperature. The 1.5-μm laser exhibits low noise characteristics, the intensity noise of the laser reaches the shot noise limit (SNL) at an analysis frequency of 4 MHz and the phase noise is less than 1 dB above the SNL at analysis frequencies above 10 MHz. 展开更多
关键词 singly resonant optical parametric oscillator 1.5-μm laser single-frequency operation low noise
下载PDF
Stochastic resonance in a single-mode laser driven by frequency modulated signal and coloured noises 被引量:1
9
作者 金国祥 张良英 曹力 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第3期952-957,共6页
By adding frequency modulated signals to the intensity equation of gain noise model of the single-mode laser driven by two coloured noises which are correlated, this paper uses the linear approximation method to calcu... By adding frequency modulated signals to the intensity equation of gain noise model of the single-mode laser driven by two coloured noises which are correlated, this paper uses the linear approximation method to calculate the power spectrum and signal-to-noise ratio (SNR) of the laser intensity. The results show that the SNR appears typical stochastic resonance with the variation of intensity of the pump noise and quantum noise. As the amplitude of a modulated signal has effects on the SNR, it shows suppression, monotone increasing, stochastic resonance, and multiple stochastic resonance with the variation of the frequency of a carrier signal and modulated signal. 展开更多
关键词 Gaussian coloured noise single-mode laser stochastic resonance frequency modulated signal
下载PDF
Stochastic Resonance in Linear Region of a Single-Mode Laser: Effects of Amplitude Modulation of Signal 被引量:1
10
作者 ZHANG Liang-Ying CAO Li WU Da-Jin 《Communications in Theoretical Physics》 SCIE CAS CSCD 2008年第5期1310-1314,共5页
A single-mode laser noise model driven by quadratic colored pump noise and amplitude modulation signal is proposed. The real and imaginary parts of the pump noise are assumed to be cross-correlation. The effect of cro... A single-mode laser noise model driven by quadratic colored pump noise and amplitude modulation signal is proposed. The real and imaginary parts of the pump noise are assumed to be cross-correlation. The effect of cross- correlation of noise and amplitude modulation of signal on laser statistical properties is studied by using the linearized approximation. The analytic expression of signal-to-noise ratio (SNR) is calculated. It is found that the phenomena of stochastic resonance (SR) respectively exist in the curves of the SNR versus the noise cross-correlation coefficient λ and the SNR versus the pump parameter a, as well as the SNR versus the signal frequency ω in our model. It is shown that there are three different typies of SR in the model: the conventional form of SR, the SR in the broad sense, and the bona fide SR. 展开更多
关键词 stochastic resonance single-mode laser amplitude modulation signal
下载PDF
Analysis of CV mode selected resonator based on vectorial eigenvector method
11
作者 You-You Hu Jian-Tai Dou +1 位作者 Bo-Wei Luo Chang-Yu He 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第2期264-271,共8页
The vectorial eigenvector method was applied to compute the cylindrical vector(CV) modes of polarization-dependent resonators and multiple modes in the CV mode selected resonator were tracked. Then, the mode character... The vectorial eigenvector method was applied to compute the cylindrical vector(CV) modes of polarization-dependent resonators and multiple modes in the CV mode selected resonator were tracked. Then, the mode characteristics of CV mode selected resonator depending on the Fresnel number, geometry parameters, and polarization parameters were simulated.When the difference in reflection coefficient between radial and azimuthal polarization is greater than 0.021 for spherical semi-confocal cavity, the radially polarized TM01*mode most probably appears in the resonator due to its lowest loss,which is consistent with an azimuthal polarization-selective resonant cavity. Moreover, the appropriate phase shift factor contributes to suppress non-rotationally symmetrical modes, which promotes the selection of CV modes. The Fresnel number between 2 and 2.5 are the appropriate range of values when the value of geometry parameters g2 is 0.5, both of which decide the effective Fresnel number. 展开更多
关键词 laser resonators polarization polarization-selective devices laserS and laser optics
下载PDF
Xe-Kr laser induced collisional ionization system and experimental preparation of its initial state: Four-photon resonant excitation
12
作者 张洪英 鲁振中 +1 位作者 樊荣伟 陈德应 《Chinese Physics B》 SCIE EI CAS CSCD 2008年第12期4504-4509,共6页
This paper proposes a novel one-colour Xe-Kr laser induced collisional ionization system. Considering the level scheme of the system, it finds that the initial state of the reaction--the four 4f levels with even J of ... This paper proposes a novel one-colour Xe-Kr laser induced collisional ionization system. Considering the level scheme of the system, it finds that the initial state of the reaction--the four 4f levels with even J of Xe-can be prepared through method of four-photon resonant excitation by dye laser with wavelength of -440 nm. Absorption of an additional photon (the transfer laser) of the same wavelength will complete the laser induced collisional ionization process. The resonance enhanced ionization spectrum of Xe by four laser photons at -440nm is measured through time-of-flight mass spectrometry, this aims at the preparation of the initial state of the system proposed. The Stark broadening of the measured spectrum is observed and consistent with the previous study. Analysis of the measured resonance ionization spectrum implies the feasibility of -440 nm four-photon resonant excitation of the initial 4f state of the Xe Kr system proposed in this paper, which prepares for a further experiment of laser induced collisional ionization. 展开更多
关键词 laser induced collision IONIZATION four-photon resonant excitation time-of-flight mass spectrometry
下载PDF
Demonstration of multi-pass amplification of 46.9 nm laser pumped by capillary discharge 被引量:1
13
作者 Dongdi Zhao Yongpeng Zhao +2 位作者 Bo An Jiaqi Li Huaiyu Cui 《Matter and Radiation at Extremes》 SCIE EI CSCD 2023年第4期16-20,共5页
Using a plane–plane resonator composed of silicon carbide mirrors,we achieve for the first time multi-pass amplification of a 46.9 nm laser pumped by capillary discharge.In terms of the temporal characteristics,for a... Using a plane–plane resonator composed of silicon carbide mirrors,we achieve for the first time multi-pass amplification of a 46.9 nm laser pumped by capillary discharge.In terms of the temporal characteristics,for an initial argon pressure of 17 Pa,triple-pass amplification of the laser is obtained at a delay time between the pre-pulse and the main pulse currents of 40s,and quadruple-pass amplification is obtained at a delay time of 50s.The experimental results show that the gain duration of the plasma column is more than 6 ns.In terms of spatial characteristics,the spot of the output laser has a reduced full width at half maximum divergence compared with that from a laser without a resonator. 展开更多
关键词 PUMPED resonator laser
下载PDF
Generation of multi-wavelength square pulses in the dissipative soliton resonance regime by a Yb-doped fiber laser
14
作者 Xude Wang Simin Yang +4 位作者 Mengqiu Sun Xu Geng Jieyu Pan Shuguang Miao Suwen Li 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第6期359-364,共6页
Multi-wavelength square pulses are generated in the dissipative soliton resonance(DSR) regime by a Yb-doped fiber laser(YDFL) with a long cavity configuration. The spectral filter effect provided by a passive fiber wi... Multi-wavelength square pulses are generated in the dissipative soliton resonance(DSR) regime by a Yb-doped fiber laser(YDFL) with a long cavity configuration. The spectral filter effect provided by a passive fiber with low-stress birefringence facilitates the establishment of multi-wavelength operation. Through appropriate control of the cavity parameters,a multi-wavelength DSR pulse can be generated in single-and dual-waveband regions. When the multi-wavelength DSR works in the 1038 nm waveband, the pulse duration can broaden from 2 ns to 37.7 ns. The maximum intra-cavity pulse energy is 152.7 nJ. When the DSR works in the 1038 nm and 1080 nm wavebands, the pulse duration can be tuned from2.3 ns to 10.5 ns with rising pump power. The emergence of the 1080 nm waveband is attributed to the stimulated Raman scattering(SRS) effect. Our work might help a deeper insight to be gained into DSR pulses in all-normal-dispersion YDFLs. 展开更多
关键词 fiber laser dissipative soliton resonance square pulse
下载PDF
IN VIVO MAPPING BRAIN MICROCIRCULATION BY LASER SPECKLE CONTRAST IMAGING:A MAGNETIC RESONANCE PERSPECTIVE OF THEORETICAL FRAMEWORK
15
作者 ZHENG WANG 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2008年第2期239-256,共18页
The fundamental limitations of most vascular-based functional neuroimaging techniques are placed by the fact how fine the brain regulates the blood supply system.In vivo mapping of the cerebral microcirculation with h... The fundamental limitations of most vascular-based functional neuroimaging techniques are placed by the fact how fine the brain regulates the blood supply system.In vivo mapping of the cerebral microcirculation with high resolution and sensitivity hence becomes unprecedentedly compelling.This paper reviews the theoretical background of the laser speckle contrast imaging(LSCI)technique and attempts to present a complete framework stemming from a simple biophysical model.Through the sensitivity analysis,more insights into the tool optimization are attained for in vivo applications.Open questions of the technical aspects are discussed within this unified framework.Finally,it concludes with a brief perspective of future research in a way analogous to the magnetic resonance imaging(MRI)technique.Such exploration could catalyze their development and initiate a technological fusion for precise assessment of blood flow across various spatial scales. 展开更多
关键词 laser speckle contrast imaging brain microcirculation functional neuroimaging magnetic resonance imaging
下载PDF
VIBRATION MEASUREMENT OF DOUBLE-ENDED TUNING FORKS RESONATOR
16
作者 LENG Changlin ZHANG Guoxiong +2 位作者 ZHONG Ying JIANG Chengzhi YU Fusheng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2006年第1期128-130,共3页
To enhance the coherence and reliability of the double-ended tuning fork (DETF) resonator, a measurement system of resonator vibration is presented to check its dynamic characteristics. Laser Doppler techniques are ... To enhance the coherence and reliability of the double-ended tuning fork (DETF) resonator, a measurement system of resonator vibration is presented to check its dynamic characteristics. Laser Doppler techniques are utilized and the relation between DETF vibration velocity and output current of photodetector is obtained. Resonator vibration equation is also analyzed and its driving power only depends on the direct current bias voltage and the amplitude of alternative voltage. Furthermore, a special resonator driving control circuit based on measurement is designed. The amplitude and frequency of circuit is controlled by a computer so that highly stable and strong driving signal can be output. Experiments on driving and measuring double-ended tuning fork have been done, The frequency of driving signal is 8 kHz and the peak-to-peak value of driving voltage is 140 V. Experimental results indicate resonator can be drived stably by driving control circuit and dynamic characteristics of DETF may be measured in real time. 展开更多
关键词 resonator Optical measurement Tuning fork MEMS laser doppler
下载PDF
Charge Resonance Enhanced Multiple Ionization of H2O Molecules in Intense Laser Fields
17
作者 刘鸿 黎敏 +5 位作者 解西国 吴聪 邓勇开 吴成印 龚旗煌 刘运全 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第6期43-47,共5页
We perform a kinetically complete measurement on the fragmentation of Coulomb explosion of 1-120 molecules in intense few-cycle linearly and circularly polarized laser fields. Both the fragmentations of 1t203+ and H... We perform a kinetically complete measurement on the fragmentation of Coulomb explosion of 1-120 molecules in intense few-cycle linearly and circularly polarized laser fields. Both the fragmentations of 1t203+ and H204+ reveal the concerted pathway of dissociation. The length of the OH bond prior to the Coulomb explosion of both molecular ions is sensitive to the laser pulse duration and laser intensity. However, the bending angle of H-O-H is less sensitive to the pulse duration and laser intensity. We introduce the mechanism of charge resonance enhanced double ionization to elucidate the triple (or quadruple) dissociative ionization dynamics of H20, in which two electrons are non-adiabatically localized at the protons of the precursor ion H2O^+ (or H2O^2+) and are released simultaneously due to the over barrier ionization in the combined laser field and molecular ionic potential. Such charge resonance enhanced multiple ionization is not suppressed in few-cycle laser fields and elliptically polarized laser fields. 展开更多
关键词 In LENGTH Charge resonance Enhanced Multiple Ionization of H2O Molecules in Intense laser Fields
下载PDF
Opto-Electronic Investigation of Wet Coating Deposition of ITO Nanopowders on Flexible Substrate Using Pulse Nd-YAG Laser
18
作者 H. Salar-Amoli H. Amani 《Optics and Photonics Journal》 2013年第4期300-303,共4页
Transparent thin layer indium tin oxide was coated on polyethylene tetraphetalate (PET) substrate by means of spin coating process and its opto-electronic properties have been investigated. The surface treated by puls... Transparent thin layer indium tin oxide was coated on polyethylene tetraphetalate (PET) substrate by means of spin coating process and its opto-electronic properties have been investigated. The surface treated by pulse Nd-YAG laser. Pulse frequency, duration and energy were, 1000 Hz, 0.2 to 20 ms and 25 to 40 J respectively. The effect of treatment on crystallization, optical properties and bonding processes of the thin layer was investigated. The results show that ITO coated on flexible PET substrates is conductive and transparent. The sheet transparency for a 350 nm thickness in the visible range is more than 83.6%. Using Nd-YAG laser increased conductivity by a factor of 100 times and causes higher bonding performances. 展开更多
关键词 PULSE nd-yag laser PET SPIN Coating Flexible Substrate Opto-Electronic
下载PDF
The Long-Lived Photon Echo Response Locking Effect in the Presence of External Non-Resonant Laser Pulses with a Different Spatial Orientation
19
作者 Leonid A. Nefed’ev Elza I. Hakimzyanova Guzel I. Garnaeva 《Optics and Photonics Journal》 2013年第7期360-363,共4页
The correlation of the inhomogeneous broadening of the resonance transition at different time intervals and the efficiency of long-lived photon echo response locking by the action of standing waves of non-resonant las... The correlation of the inhomogeneous broadening of the resonance transition at different time intervals and the efficiency of long-lived photon echo response locking by the action of standing waves of non-resonant laser pulses are considered. It is shown that the long-lived photon echo response locking effect may be observed even at the angles of the relative orientation of the non-resonant standing wave laser pulses of less than one degree, due to the change in the correlation coefficient of inhomogeneous broadening at time intervals between the first and the second and after the third resonant laser pulses. 展开更多
关键词 Photon Echo The Information LOCKING Spatial Non UNIFORM Electromagnetic Fields Relaxation Processes Time of The RESPONSE EXTERNAL Space-Non UNIFORM Non resonANT laser Pulses
下载PDF
Effect of mitomycin combined with Nd-YAG laser on cell proliferation and invasion as well as MEK/ERK signaling pathway in obstructive lacrimal duct model
20
作者 Yu Yan Shuang-Le Li 《Journal of Hainan Medical University》 2017年第21期17-20,共4页
Objective: To study the effect of mitomycin (MMC) combined with Nd-YAG laser on cell proliferation and invasion as well as MEK/ERK signaling pathway in obstructive lacrimal duct model. Methods: New Zealand rabbits wer... Objective: To study the effect of mitomycin (MMC) combined with Nd-YAG laser on cell proliferation and invasion as well as MEK/ERK signaling pathway in obstructive lacrimal duct model. Methods: New Zealand rabbits were selected as experimental animals and divided into model group, laser group and MMC + laser group;obstructive lacrimal duct model was established, then laser group were given Nd-YAG laser intervention, and MMC + laser group were given Nd-YAG laser combined with mitomycin intervention. 2 months after intervention, the expression of proliferation molecules, invasion molecules and MEK-ERK signaling molecules in lacrimal duct tissue were measured. Results: TGF-β, CTGF, PCNA, Ki-67, Col-I, Col-III, MEK, ERK1/2, MMP2 and MMP9 protein levels in lacrimal duct tissue of laser group were significantly higher than those of model group while TSG-6, Cthrc1 and TIMP1 protein levels were significantly lower than those of model group;TGF-β, CTGF, PCNA, Ki-67, Col-I, Col-III, MEK, ERK1/2, MMP2 and MMP9 protein levels in lacrimal duct tissue of MMC + laser group were significantly lower than those of laser group while TSG-6, Cthrc1 and TIMP1 protein levels were significantly higher than those of laser group. Conclusion:Mitomycin can inhibit cell proliferation and invasion as well as MEK/ERK signaling pathway activation in obstructive lacrimal duct model after Nd-YAG laser treatment. 展开更多
关键词 LACRIMAL duct obstruction disease nd-yag laser MITOMYCIN C Proliferation INVASION
下载PDF
上一页 1 2 64 下一页 到第
使用帮助 返回顶部