LARGE DEVIATIONS AND MODERATE DEVIATIONS FOR m-NEGATIVELY ASSOCIATED RANDOM VARIABLES

M-negatively associated random variables, which generalizes the classical one of negatively associated random variables and includes m-dependent sequences as its particular case, are introduced and studied. Large deviation principles and moderate deviation upper bounds for stationary m-negatively associated random variables are proved. Kolmogorov-type and Marcinkiewicz-type strong laws of large numbers as well as the three series theorem for m-negatively associated random variables are also given.

Complete Moment Convergence for Arrays of Rowwise Negatively Associated Random Variables

In this paper, the authors present some new results on complete moment convergence for arrays of rowwise negatively associated random variables. These results improve some previous known theorems.

CONVERGENCERATESIN THESTRONG LAWSOFASYMPTOTICALLY NEGATIVELY ASSOCIATEDRANDOM FIELDS

In this paper, a notion of negative side ρ \|mixing ( ρ\+- \|mixing) which can be regarded as asymptotic negative association is defined, and some Rosenthal type inequalities for ρ\+- \|mixing random fields are established. The complete convergence and almost sure summability on the convergence rates with respect to the strong law of large numbers are also discussed for ρ\+-\| mixing random fields. The results obtained extend those for negatively associated sequences and ρ\+*\| mixing random fields.

Complete Convergence of Weighted Sums for Arrays of Rowwise m-negatively Associated Random Variables

In this paper, we discuss the complete convergence of weighted sums for arrays of rowwise m-negatively associated random variables. By applying moment inequality and truncation methods, the sufficient conditions of complete convergence of weighted sums for arrays of rowwise m-negatively associated random variables are established. These results generalize and complement some known conclusions.

Complete Convergence of Weighted Sums for Asymptotically Almost Negatively Associated Sequences

For weighted sums of asymptotically almost negatively associated (AANA) random variables sequences, we use the Rosenthal type moment inequalities and prove the Marcinkiewicz-Zygmund type complete convergence and obtain the complete convergence rates. Our results extend some known ones.

NA样本下随机设计情形部分线性模型的经验似然推断

本文研究NA样本下随机设计情形部分线性模型的经验似然推断,将分块技术应用到经验似然方法中,证明部分线性模型的参数β的对数经验似然比统计量的渐近分布为卡方分布,由此构造了NA样本下β的经验似然置信区间.同时,在有限样本情况下给出运用分块技术的经验似然与不运用分块技术的经验似然的模拟对比结果.

Electrochemical behavior of gold and its associated minerals in alkaline thiourea solutions

Electrochemical measurements were conducted to study the electrochemical behavior of gold （Au） and its commonly associated minerals in alkaline thiourea solutions. The results indicated that without addition of any stabilizer, selective dissolution of Au from stibnite and pyrite was only possible at relatively low thiourea concentrations. As Na2SiO3 was added, pyrite started to become active and an oxida- tion peak appeared; the oxidation peaks of axsenopyrite and chalcocite appeared earlier thaxl that of Au. The chalcocite peak shifted in the positive direction and the peak current increased. Stibnite did not show an oxidation peak and its current was nearly zero. Adding Na2SiO3 favored the selective dissolution of Au when its minerals were associated with chalcocite and stibinte. At pH 12, the Au anode dissolution peak current increased with stabilizer concentration. At 0.38 and 0.42 V and for Na2SiO3 concentration below 0.09 M, the current density continuously increased with Na2SiO3 concentration. The Na2SiO3 concentration had to be adequate to stabilize thiourea. When the potential was higher than 0.42 V, the surface of the Au electrode started to passivate. With an additional increase in potential, the presence of Na2SiO3 could not stop the inevitable decomposition of thiourea.

Effect of High-fat Diet on Cholesterol Metabolism in Rats and Its Association with Na^+/K^+-ATPase/Src/pERK Signaling Pathway

Summary： Abnormal cholesterol metabolism is associated with an elevated risk of developing athero- sclerosis, hypertension, and diabetes etc. Na＋/K＋-ATPase was found to regulate cholesterol synthesis, distribution and trafficking. This study aimed to examine the effect of high-fat diet on cholesterol me- tabolism in rats and the role of Na＋/K＋-ATPase/Src/ERK signaling pathway in the process. Forty male SD rats were evenly divided into high-fat diet group and control group at random. Animals in the former group were fed on high-fat diet for 12 weeks, and those fed on basic diet served as control. Blood lipids, including total cholesterol （TC）, triglyceride （TG）, high density lipoprotein-cholesterol （HDL-C）, and low density lipoprotein-cholesteral （LDL-C） levels, were detected at 3, 6 and 12 weeks. The ratio of cholesterol content in cytoplasm to that in cell membrane was detected in liver tissues. RT-PCR and Western blotting were used to measure the expression of lipid metabolism-associated genes （HMG-CoA reductase and SREBP-2） after 12-week high-fat diet. Na＋/K＋-ATPase/Src/ERK signaling path- way-related components （Na＋/K＋-ATPase ctl, Src-PY418 and pERK1/2） were also measured by West- ern blotting. The results showed that the serum TC, TG, and LDL-C levels were significantly higher in high-fat diet group than those in control group, while the HDL-C level was significantly lower in high-fat diet group at 6 weeks （P〈0.01）. High-fat diet led to an increase in the cholesterol content in the cytoplasm and cell membrane. The ratio of cholesterol content in cytoplasm to that in cell membrane was elevated over time. The expression of HMG-CoA reductase and SREBP-2 was significantly sup- pressed at mRNA and protein levels after 12-week high-fat diet （P〈0.05）. Moreover, high-fat diet pro- moted the expression of Na＋/K＋-ATPase α1 but suppressed the phosphorylation of Src-PY418 and ERK1/2 at 12 weeks （P〈0.05）. It was concluded that high-fat diet regulates cholesterol metabolism, and Na＋/K＋-ATPase signaling pathway is involved in the process possibly by regulating the expression of lipid metabolism-associated proteins HMG-CoA reductase and SREBP-2.

Degradation mechanism of tin phosphide as Na-ion battery negative electrode

The degradation mechanism of an Sn_4P_3 electrode as Na-ion battery anode was investigated by using a transmission electron microscopic observation. At the first desodiation, we confirmed that Sn nanoparticles with 6 nm in size were dispersed in an amorphous-like P matrix.Compared to this, we observed aggregated Sn particles with sizes exceeding 50 nm after the drastic capacity fading. The capacity fading mechanism was for the first time confirmed to be Sn aggregation. To improve the capacity decay, we carried out the two kinds of chargeàdischarge cycling tests under the reduced volume changes of Sn particles and P matrix by limiting desodiation reactions of Nae Sn and Na3P, respectively. The Sn_4P_3 electrode exhibited an excellent cyclability with the discharge capacity of 500 mA hg^(-1) for 420 cycles under the limited desodiation, whereas the capacity decay was accelerated under the limited sodiation. The results suggest that the Sn aggregation can be improved by the reduced volume change of the P matrix, and that it is very effective for improving anode performance of Sn_4P_3 electrode.

Candida-associated gastric ulcer relapsing in a different position with a different appearance

An 87-year-old,Japanese woman was shown to have a submucosal tumor-like lesion with a deep,central ulceration covered with thick,whitish exudate in the stomach.Biopsy showed Candida tropicalis but not Helicobacter pylori(H.pylori).She had no predisposing factors or history of peptic ulcers nor had taken non-steroidal anti-inflammatory drugs(NSAIDs),diagnosed with Candida-associated gastric ulcer.Though cured of the lesion,she developed another ulcer in a different position,in which Candida was demonstrated but H.pylori was undetectable.This is the first case of recurrent Candida-associated gastric ulcer in the world.Detected in both the original and recurrent lesions in an H.pylori-negative patient with no antecedent ulcers who had not taken NSAIDs,Candida is considered,contrary to the prevailing opinion,to play an etiologic role in ulcer formation.

On the Strong Laws for Weighted Sums of m-negatively Asso ciated Random Variables

In this article, the author establishes the strong laws for linear statistics that are weighted sums of a m-negatively associated(m-NA) random sample. The obtained results extend and improve the result of Qiu and Yang in [1] to m-NA random variables.

Research on Algorithm for Mining Negative Association Rules Based on Frequent Pattern Tree

Typical association rules consider only items enumerated in transactions. Such rules are referred to as positive association rules. Negative association rules also consider the same items, but in addition consider negated items （i. e. absent from transactions）. Negative association rules are useful in market-basket analysis to identify products that conflict with each other or products that complement each other. They are also very convenient for associative classifiers, classifiers that build their classification model based on association rules. Indeed, mining for such rules necessitates the examination of an exponentially large search space. Despite their usefulness, very few algorithms to mine them have been proposed to date. In this paper, an algorithm based on FP tree is presented to discover negative association rules.

Backward Support Computation Method for Positive and Negative Frequent Itemset Mining

Association rules mining is a major data mining field that leads to discovery of associations and correlations among items in today’s big data environment. The conventional association rule mining focuses mainly on positive itemsets generated from frequently occurring itemsets (PFIS). However, there has been a significant study focused on infrequent itemsets with utilization of negative association rules to mine interesting frequent itemsets (NFIS) from transactions. In this work, we propose an efficient backward calculating negative frequent itemset algorithm namely EBC-NFIS for computing backward supports that can extract both positive and negative frequent itemsets synchronously from dataset. EBC-NFIS algorithm is based on popular e-NFIS algorithm that computes supports of negative itemsets from the supports of positive itemsets. The proposed algorithm makes use of previously computed supports from memory to minimize the computation time. In addition, association rules, i.e. positive and negative association rules (PNARs) are generated from discovered frequent itemsets using EBC-NFIS algorithm. The efficiency of the proposed algorithm is verified by several experiments and comparing results with e-NFIS algorithm. The experimental results confirm that the proposed algorithm successfully discovers NFIS and PNARs and runs significantly faster than conventional e-NFIS algorithm.

长链非编码RNA MIAT在子宫颈癌中的表达水平及临床意义研究

目的观察长链非编码RNA心肌梗死相关转录本(long non coding RNA myocardial infarction associated transcript,lnc RNA MIAT)在子宫颈癌(cervical cancer,CC)中的表达情况,旨在为CC患者的早期诊断及预后评估提供可靠的实验指标。方法收集2018年1月—2020年12月于枣庄市立医院住院的子宫颈癌患者30例,并对患者进行分期,通过qRT-PCR方法,检测血清、子宫颈癌组织及癌旁正常组织中lnc RNA MIAT的表达水平,并每隔6个月监测患者血清中lnc RNA MIAT的表达水平,分析血清学lnc RNA MIAT的表达水平与子宫颈癌患者临床病理学指标及子宫颈癌生存率的相关性。结果(1)Ⅲ~Ⅳ期子宫颈癌患者血清中及癌组织中lncRNA MIAT的表达水平高于Ⅰ~Ⅱ期,差异有统计学意义(t=18.567,21.333,P<0.05)。(2)子宫颈癌患者病理特征如肿瘤直径>4cm,有淋巴结转移、Ⅲ及Ⅳ期、有复发/死亡者中,lncRNAMIAT表达水平显著高于其他项,差异有统计学意义(P<0.05),且lncRNA MIAT表达水平与子宫颈癌患者临床分期指标呈正相关,(r=0.665)。(3)lncRNAMIAT高表达组患者术后2年生存率低于低表达组(χ^(2)=3.871,P=0.037),每隔6个月表达水平与术后复发率呈正相关(r=0.834),与预后呈负相关(r=-0.789)。结论子宫颈癌中lncRNA MIAT的表达水平增高,且与子宫颈癌患者的临床分期存在相关性。术后患者血清中lncRNA MIAT的表达水平与预后呈负相关,对患者的预后评估具有潜在价值。

Precise Large Deviations for Sums of Negatively Associated Random Variables with Common Dominatedly Varying Tails

In this paper, we obtain results on precise large deviations for non-random and random sums of negatively associated nonnegative random variables with common dominatedly varying tail distribution function. We discover that, under certain conditions, three precise large-deviation prob- abilities with different centering numbers are equivalent to each other. Furthermore, we investigate precise large deviations for sums of negatively associated nonnegative random variables with certain negatively dependent occurrences. The obtained results extend and improve the corresponding results of Ng, Tang, Yan and Yang （J. Appl. Prob., 41, 93-107, 2004）.

NA样本及Linex损失下截断族参数的经验EB估计(英文)

在Linex损失及NA样本下 ,对一类双边截断型分布族 ,构造了参数的经验Bayes(EB)估计 ,建立了它的收敛速度 .在一定的条件下证明了该收敛速度可以任意接近于 1 ,并给出满足定理条件的例子 .

钠钾ATP酶抑制剂通过调节DNA损伤感应复合体Mre11/Rad50/Nbs1的表达诱导肝癌HepG2细胞周期阻滞

目的研究钠钾ATP酶抑制剂华蟾毒配基(cinobufagin)对人肝癌HepG2细胞DNA损伤修复阻断及其发生机制。方法免疫组化分析人肝癌临床组织标本、正常肝组织中钠钾ATP酶α1亚单位的表达;以人肝癌细胞HepG2为靶细胞,实验分为对照组、5μmol·L^(-1)华蟾毒配基作用6、12和24 h组;单细胞电泳检测DNA双链断裂,Real time-PCR和Western blot检测损伤修复基因Mre11、Rad50、Nbs1和p53的表达变化,流式细胞术检测细胞周期。结果肝癌组织钠钾ATP酶α1亚单位表达与癌旁组织相比明显升高(P<0.05);华蟾毒配基诱导HepG2细胞DNA断裂的发生率与作用时间高度相关,作用时间延长断裂效应更加明显(P<0.05),Mre11,Nbs1,Rad50和p53表达随药物作用时间延长逐渐升高(P<0.05),流式细胞术分析细胞周期对照组S期细胞比例为(21.32±4.21)%,5μmol·L^(-1)华蟾毒配基处理6 h后为(33.25±5.72)%,处理12 h后为(56.72±6.29)%,作用24 h后为(67.32±9.42)%。结论华蟾毒配基激活Mre11/Rad50/Nbs1损伤感应复合体介导肝癌Hep G2细胞周期阻滞。

NA序列的部分和乘积的渐近正态性

设{Xn;n≥1}是一列同分布的NA序列,μ=EX1>0,σ2=VarX1<∞.在适当的条件下证明了∏nk=1Skn!μn1γσndeN,n→∞,其中Sk=∑ki=1Xi,γ=σ/μ,σ2n=Varγ1∑k=n1kSμk-1,N是标准正态随机变量.

中国散裂中子源伴生质子辐照实验平台及其技术参数的确定

为了利用负氢离子加速器中伴随产生的质子成分,中国散裂中子源(China Spallation Neutron Source,CSNS)在直线加速器末端建设了伴生质子辐照实验平台(associated protons experimental platform,APEP)。为了确定其性能参数,采用散射测量、束斑照相、同位素活化法等实验方法对伴生质子辐照实验平台的主要参数进行了刻度。实验证实,该辐照平台可以提供的质子能量范围为10~80 MeV,束斑分布均匀,束流强度范围为1.2×10^(7)~4.0×10^(9) cm^(-2)·s^(-1)。伴生质子辐照实验平台运行稳定,每年提供超过5000 h的束流时间,可以满足宇航器件可靠性测试、探测器刻度、辐照育种以及材料抗辐照特性测试等多种应用需求。

NA、PA样本下密度核估计的相合性

设 { Xn,n 1}为同分布的 NA或 PA随机变量序列 ,f (x)为 X1 概率密度函数 ,基于样本 X1 ,X2 ,… ,Xn,本文对密度函数 f (x)的核估计进行了讨论 ,在适当条件下证明了其强相合和 r阶矩相合 .