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Meningitis Outbreak Caused by Neisseria meningitidis Serogroup C ST 10217 in 2019 in Diapaga, Burkina Faso
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作者 Kambiré Dinanibè Tondé Issa +16 位作者 Ouédraogo W. H. Gautier Sanou Mahamoudou Ouédraogo L. S. L. Wilfrid Savadogo Mahamoudou Tamboura Mamadou Zongo Moumouni Ouédraogo Oumarou Zouré Abdou Azaque Compaoré Rebeca Sagna Tani Zida Sylvie Soubeiga R. S. Théophile Aké Flavien Sangaré Lassana Méda Isaïe Kouanda Séni Ouédraogo-Traoré Rasmata 《Advances in Infectious Diseases》 CAS 2023年第1期66-76,共11页
Introduction: Meningitis caused by Neisseria meningitidis constitutes a burden for the countries in the meningitis belt of sub-Saharan in general and particularly for Burkina Faso. In 2019 the Diapaga health district ... Introduction: Meningitis caused by Neisseria meningitidis constitutes a burden for the countries in the meningitis belt of sub-Saharan in general and particularly for Burkina Faso. In 2019 the Diapaga health district experienced a meningitis epidemic due to N. meningitidis serogroup C. Methods: This is a cross-sectional study with a descriptive aim in the health district of Diapaga where all cases of meningitis were included in this work. Rapid diagnostic tests (RDTs), culture as well as real-time PCR were used for the biological analysis of cerebral spinal fluid (CSF) samples. Results: Of 155 CSF samples analysed, 42% (65/155) were tested positve. Of them, N. meningitidis C accounted for 83% of all positive cases. Likewise, all thirteen (13) NmC strains were susceptible to oxacillin, ceftriaxone, penicillin and chloramphenicol. All strains of NmC belonged to the sequence type (ST) 10 217 and to the clonal complex (CC) 10 217. These CCs belonged to the same variant PorA type: P1.21-15.16;FetA type: F1-7;PorB type: 3-463. Conclusion: Burkina Faso had known an epidemic of meningitis caused by NmC in 2019 in the health district of Diapaga. This outbreak was contained in time due to the performance of the epidemiological surveillance system which made it possible to investigate on time and introduce the vaccine against the pathogen NmC. 展开更多
关键词 MENINGITIS neisseria meningitidis VS Diapaga Burkina Faso
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Molecular Characteristics of Neisseria meningitidis Isolated during an Outbreak in a Jail: Association with the Spread and Distribution of ST-4821 Complex Serogroup C Clone in China 被引量:5
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作者 ZHANG Ji ZHOU Hai Jian +5 位作者 XU Li HU Guang Chun ZHANG Xue Hua XU Sheng Ping LIU Zun Yu SHAO Zhu Jun 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第5期331-337,共7页
Objective To characterize the meningococcal strains isolated from cases and close contacts with meningococcal disease associated with an outbreak in a jail in May 2010 by investigating the national distribution of hyp... Objective To characterize the meningococcal strains isolated from cases and close contacts with meningococcal disease associated with an outbreak in a jail in May 2010 by investigating the national distribution of hyperinvasive ST-4821 serogroup C clone associated with this outbreak. Methods The cases were described based on the clinical symptoms and laboratory results. Pharyngeal swabs were cultured for N. meningitidis from men in the jail. Meningococcal isolates were identified by serogrouping, pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST), respectively. Four hundred and sixteen serogroup C N. meningitidis strains were collected from 27 provinces between 2003 and 2010 for a nationwide survey and analyzed by PFGE and MLST. Results Three persons in a jail system were infected with invasive N. meningitidis serogroup C. All isolates tested had matching PFGE patterns and belonged to the multilocus sequence type (ST) 4821 clonal complex. All 47 N. meningitidis strains were identified from the pharyngeal swabs of 166 peoples in the jail, and 26 of them belonged to ST-4821 serogroup C clone, and 90.14% (375/416) serogroup C strains identified in the nationwide survey belonged to the ST-4821 complex. The ST-4821 serogroup C clone was spread nationwide, distributed in 24 provinces, especially in eastern provinces between 2003 and 2010. Conclusion Endemic transmission and carriage rate of ST-4821 serogroup C clone are high in this jail system. The ST-4821 serogroup C clone is spreading in China and nationwide distributed despite the existence of some effective vaccines. 展开更多
关键词 Pulsed-field gel electrophoresis Multilocus sequence typing neisseria meningitidis ST-4821 serogroup C
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Proteome Analysis of Neisseria meningitidis Serogroup Strains C Associated with Outbreaks in China 被引量:1
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作者 YUAN HU ZHU-JUN SHAO +18 位作者 XIAO-MEI YAN BO-QING LI FEI ZHAO DI XIAO JUN REN MING-HUAN ZHENG CHUN-XIANG FAN LI-HUA HE LI XU YI-XIN GU HAI JIANG FENG-HUA GUO ZHEN-WEI DAI HONG-YU REN MEI-JUAN LU XIA CHEN QING-HUA ZOU FAN-LIANG MENG JIAN-ZHONG ZHANG 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2010年第4期251-258,共8页
Objective During 2003-2005, an outbreak of meningitis due to Neisseria meningitidis serogroup C occurred in China. With the aim to find strain clues result in the final epidemics, the ancestral strain 053442, a clinic... Objective During 2003-2005, an outbreak of meningitis due to Neisseria meningitidis serogroup C occurred in China. With the aim to find strain clues result in the final epidemics, the ancestral strain 053442, a clinical isolate, and a carrier strain 053426 with different gene type were analyzed. Methods Clinical strain 053442 and carrier strain 053426 were cultured on GC agar plates under the same condition. Two-dimensional electrophoresis was performed using the pH 3–10 nonlinear IPG strips of 24 cm length, and all the protein spots were identified by matrix-assisted laser desorption/ionization time of flight spectrometry. Results 502 and 380 protein spots were identified in 053426 and 053442 respectively, relating to 266 and 202 different genes covering a wide range of cellular functions. The express volume and number of proteins involved in energy metabolism, protein synthesis and amino acid biosynthesis in 053426 were higher than in 053442. Virulence factor Opa, Opc and a series of proteins involved in pilus assembly and retraction were identified in 053442, which appear to be of primary importance in colonization and invasion of human cells. Compared to 053442, virulence protein species were less in 053426, with lower express volumes too. No Opa and Opc were detected in 053426. Conclusion The different protein expression profiles of the clinical strain 053442 and carrier strain 053426 in the present study provide some clues of the different pathogenicity of the two strains, which may account for result in the final epidemics. 展开更多
关键词 neisseria meningitidis Reference map Two-dimensional gel electrophoresis MaLDI-TOF/TOF-MS
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Antimicrobial susceptibility and serotypes of Neisseria meningitidis and Streptococcus pneumoniae in Sri Lanka:Experience from the National Reference Laboratory
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作者 Lilani Karunanayake Veeraraghavan Balaji +10 位作者 K.D.N.Gunawardana Rosemol Varghese Vayishnavi Ariram Malka Dassanayake Vaithehi Rajeevan Francis Lakmini Yapa Chamika Herath Nambage Shirani Chandrasiri Priyanka Wimalagunawardhana K.Dhananja Namalie C.T.Hapuarachchi 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2022年第3期114-120,共7页
Objective:To determine the antimicrobial susceptibility and serotypes of Neisseria(N.)meningitidis and Streptococcus(S.)pneumoniae in Sri Lankan patients.Methods:We retrospectively analyzed 11 blood culture specimens ... Objective:To determine the antimicrobial susceptibility and serotypes of Neisseria(N.)meningitidis and Streptococcus(S.)pneumoniae in Sri Lankan patients.Methods:We retrospectively analyzed 11 blood culture specimens from suspected patients with invasive meningococcal disease and 26 S.pneumoniae clinical isolates.We tested 6 antimicrobials against N.meningitidis and 12 antimicrobials against S.pneumoniae.Meningococcal serogroup was determined by realtime PCR and Quellung serotyping was used for pneumococcal analysis.Results:N.meningitidis serogroup B was the most common in this study.Intermediate-susceptibility to penicillin was seen in 75.0%(6/8)of strains.Susceptibility to ciprofloxacin,levofloxacin and cotrimoxazole was 62.5%(5/8),62.5%(5/8)and 87.5%(7/8),respectively.Excellent susceptibility was seen in cefotaxime and meropenem.In S.pneumoniae,the most common serotype was 19F in both invasive and non-invasive pneumococcal diseases.The majority of strains showed multidrug resistance.Penicillin non-susceptibility in non-meningeal strains were 13.6%and all meningeal strains were penicillin resistant.Erythromycin was highly resistant in both groups.Amoxicillin showed excellent susceptibility in non-invasive pneumococcal diseases strains.Linezolid,levofloxacin and vancomycin showed 100.0%susceptibility in all pneumococcal isolates.Conclusions:Implementation of vaccines should be considered,especially for children and high-risk populations.This may contribute to reducing pneumococcal and meningococcal invasive disease burden and help prevent emergence of antimicrobial resistant strains. 展开更多
关键词 neisseria meningitidis Streptococcus pneumoniae Sri Lanka antimicrobial resistance SEROTYPES Invasive bacterial diseases
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Excellent outcome of primary Neisseria meningitidis keratoconjunctivitis
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作者 Jakiyah Daud Siti Raihan Ishak +1 位作者 Zakuan Zainy Deris Wan Hazabbah Wan Hitam 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2011年第5期419-420,共2页
Infectious conjunctivitis is a very common presentation to medical professional and ophthalmologist all over the world.Although its typically self-limiting and treatable in almost all of the cases,but we need to be aw... Infectious conjunctivitis is a very common presentation to medical professional and ophthalmologist all over the world.Although its typically self-limiting and treatable in almost all of the cases,but we need to be aware of the rare and potentially life threatening if the cause is not promptly identified and treated accordingly.In our case report,we highlighted the rare case of Neisseria meningitidis as a primary cause of keratoconjunctivitis.Neisseria meningitidis is a rare etiology of keratoconjunctivitis and its ocular presentations are quite similar with other bacterial or viral infection.The infection may potentially fatal if systemic invasion occurred,however with immediate and proper treatment the outcome is satisfactory.Early diagnosis and proper antibiotic treatment are critical to prevent systemic spread of the infection.Public health intervention is needed to prevent outbreak of the disease. 展开更多
关键词 neisseria meningitidis KERaTOCONJUNCTIVITIS
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Surface adhesion and host response as pathogenicity factors of Neisseria meningitidis
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作者 Jose Uberos M Molina-Oya +1 位作者 S Martinez-Serrano L Fernández-López 《World Journal of Clinical Infectious Diseases》 2015年第2期37-43,共7页
Neisseria meningitidis(N.meningitidis) is an exclusively human pathogen that has been identified in 10%-35% of the adult population and in 5.9% of the child population.Despite the high prevalence of carriers of N.meni... Neisseria meningitidis(N.meningitidis) is an exclusively human pathogen that has been identified in 10%-35% of the adult population and in 5.9% of the child population.Despite the high prevalence of carriers of N.meningitidis,it only occasionally causes meningococcal disease in the context of endemic disease,in certain geographic areas or in isolated epidemic outbreaks.After the N.meningitidis genome is described,progress has been made toward understanding the pathogenic mechanisms of the bacteria,although some aspects concerning its interaction with the environment and the host remain unclear.Some studies have reported that oxidative stress in the environment can modify the surface characteristics of N.meningitidis,increasing its adhesive properties and favouring an asymptomaticcarrier state.The antigenic structure of N.meningitidis can be modified by its importing genetic material from other bacteria in its ecological niche.Some structures of lipopolysaccharides help it to evade the immune response,and these are observed more frequently in N.meningitidis isolated from blood than in healthy nasopharyngeal carriers.There is evidence that pili and capsule are downregulated upon contact with target cells.This paper reviews current knowledge on hostenvironment-bacteria mechanisms and interactions,with the aim of contributing to our understanding of the pathogenic mechanisms of N.meningitidis. 展开更多
关键词 BaCTERIaL aDHESION neisseria meningitidis VIRULENCE
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A first meningococcal meningitis case caused by serogroup X Neisseria meningitidis strains in China 被引量:13
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作者 CHEN Chao ZHANG Tie-gang +7 位作者 HE Jing-guo WU Jiang CHEN Li-juan LIU Jun-feng PANG Xing-huo YANG Jie SHAO Zhu-jun HUANG Ying-chun 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第7期664-666,共3页
Neisseria meningitidis is the leading cause of bacterial meningitis and classified into 13serogroups based on the immunological reactivity of the capsular polysaccharide.1 Serogroups A, B, C, W135 and Y are the most c... Neisseria meningitidis is the leading cause of bacterial meningitis and classified into 13serogroups based on the immunological reactivity of the capsular polysaccharide.1 Serogroups A, B, C, W135 and Y are the most common causes of meningitis.2 Among them, serogroup A and C are the major causes of epidemics in Africa and Asia.2 Most of the epidemic outbreaks of meningococcal meningitis are caused by serogroup A Neisseria meningitidis strain from the 1950s to the 1980s in China.3 During the years 2003 and 2005, a new sequence type (ST-4821) of serogroup C was identified in the Anhui and 11 other provinces of China.4 展开更多
关键词 multilocus sequence typing neisseria meningitidis serogroup X
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Molecular characterizations of serogroup B Neisseria meningitidis strains circulating in Beijing 被引量:2
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作者 ZHANG Tie-gang CHEN Chao +6 位作者 HE Jing-guo WU Jiang CHEN Li-juan PANG Xing-huo YANG Jie SHAO Zhu-jun HUANG Ying-chun 《Chinese Medical Journal》 SCIE CAS CSCD 2009年第5期584-587,共4页
Neisseria meningitidis (N. meningitidis) is classified into 13 serogroups based on the immunological reactivity of the capsular polysaccharide.Serogourp-s A,B and C are responsible for over 90% of meningococcal dise... Neisseria meningitidis (N. meningitidis) is classified into 13 serogroups based on the immunological reactivity of the capsular polysaccharide.Serogourp-s A,B and C are responsible for over 90% of meningococcal disease.2 In developed countries, endemic disease is generally caused by serogroups B and C. 展开更多
关键词 neisseria meningitidis outer membrane protein pulsed-field gel electrophoresis serogroup B
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A Novel Interpretation of Structural Dot Plots of Genomes Derived from the Analysis of Two Strains of Neisseria meningitidis
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作者 Wilfred R. Cuff Venkata R.S.K. Duvvuri +4 位作者 Binhua Liang Bhargavi Duvvuri Gillian E. Wu Jianhong Wu Raymond S.W. Tsang 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2010年第3期159-169,共11页
Neisseria meningitidis is the agent of invasive meningococcal disease, including cerebral meningitis and septicemia. Because the diseases caused by different clonal groups (sequence types) have their own epidemiolog... Neisseria meningitidis is the agent of invasive meningococcal disease, including cerebral meningitis and septicemia. Because the diseases caused by different clonal groups (sequence types) have their own epidemiological characteristics, it is important to understand the differences among the genomes of the N. meningitidis clonal groups. To this end, a novel interpretation of a structural dot plot of genomes was devised and applied; exact nu- cleotide matches between the genomes ofN. meningitidis serogroup A strain Z2491 and serogroup B strain MC58 were identified, leading to the specification of various structural regions. Known and putative virulence genes for each N. meningitidis strain were then classified into these regions. We found that virulence genes of MC58 tend more to the translocated regions (chromosomal segments in new sequence contexts) than do those of Z2491, notably tending towards the interface between one of the translocated regions and the collinear region. Within the col- linear region, virulence genes tend to occur within 16 kb of gaps in the exact matches. Verification of these tendencies using genes clustered in the cps locus was sufficiently supportive to suggest that these tendencies can be used to focus the search for and understanding of virulence genes and mechanisms of pathogenicity in these two organisms. 展开更多
关键词 structural dot plots virulence genes TRaNSLOCaTION match regions MUMmer neisseria meningitidis
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南通市首例B群流行性脑脊髓膜炎病例报道
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作者 高兴 金红梅 +1 位作者 廉丽华 陈杰 《中国初级卫生保健》 2024年第11期74-76,共3页
目的:对南通市首例B群流行性脑脊髓膜炎(以下简称流脑)病例进行报告分析。方法:对2022年2月南通大学附属医院报告的1例实验室确诊流脑病例开展流行病学调查,采集病例血液和脑脊液标本进行脑膜炎奈瑟菌分离培养、血清群PCR鉴定及药物敏... 目的:对南通市首例B群流行性脑脊髓膜炎(以下简称流脑)病例进行报告分析。方法:对2022年2月南通大学附属医院报告的1例实验室确诊流脑病例开展流行病学调查,采集病例血液和脑脊液标本进行脑膜炎奈瑟菌分离培养、血清群PCR鉴定及药物敏感性试验。结果:该病例为26岁女性,自述既往接种过流脑疫苗,接种记录不详,无流脑病例接触史,无续发病例出现。从该病例的血液标本中分离培养出脑膜炎奈瑟菌,经鉴定为脑膜炎奈瑟菌B群;菌株对氨苄西林、头孢噻肟、氯霉素、米诺环素、利福平、左氧氟沙星敏感,对复方新诺明耐药。结论:该病例为南通市报告的首例B群流脑,提示南通市流行菌群可能发生变迁,B群流脑有流行风险,应加强流脑病原学监测。 展开更多
关键词 流行性脑脊髓膜炎 脑膜炎奈瑟菌 B群 流行病学
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成都市健康人群流脑A群和C群抗体水平监测及A+C群流脑疫苗免疫效果分析 被引量:15
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作者 张晓春 蔡军 王杰 《现代预防医学》 CAS 北大核心 2007年第4期822-824,共3页
[目的]本文调查了成都市部分健康人群A群和C群流脑的抗体水平,同时研究了2~15岁人群对A+C群流脑多糖疫苗接种1个月后的抗体免疫反应。[方法]采用ELISA法检测不同人群血清中的A群和C群流脑抗体。[结果]健康人群A群的抗体GMT及阳性率为5... [目的]本文调查了成都市部分健康人群A群和C群流脑的抗体水平,同时研究了2~15岁人群对A+C群流脑多糖疫苗接种1个月后的抗体免疫反应。[方法]采用ELISA法检测不同人群血清中的A群和C群流脑抗体。[结果]健康人群A群的抗体GMT及阳性率为5.76、69.05%,C群的抗体GMT及阳性率为1.942、5.36%。A+C群流脑多糖疫苗免疫后1个月,A群的抗体GMT及阳性率上升为15.10、100.00%,C群的抗体GMT及阳性率上升为18.57、97.92%。A群的MFC及免疫成功率为3.26、52.78%,C群的MFC及免疫成功率为6.53、79.86%。[讨论]健康人群的A群抗体水平高于C群,A+C群流脑多糖疫苗的C群免疫效果优于A群。有必要对成人进行流脑疫苗免疫。 展开更多
关键词 流脑 抗体水平 a+C群脑膜炎多糖疫苗 免疫
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MenA PS-EA偶联物的制备及其在多糖抗体检测中的应用 被引量:3
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作者 肖丽君 赵恩山 +1 位作者 孔健 蒋先敏 《中国生物制品学杂志》 CAS CSCD 2008年第7期611-614,共4页
目的制备MenA PS-EA偶联物及以MenA PS-EA为包被抗原的A群脑膜炎奈瑟菌多糖IgG抗体的ELISA检测试剂。方法培养A群脑膜炎奈瑟菌,提取多糖(MenA PS),与卵清蛋白(EA)以还原氨基法偶联,Sepharose CL-4B纯化。制备以MenA PS-EA为包被抗原的A... 目的制备MenA PS-EA偶联物及以MenA PS-EA为包被抗原的A群脑膜炎奈瑟菌多糖IgG抗体的ELISA检测试剂。方法培养A群脑膜炎奈瑟菌,提取多糖(MenA PS),与卵清蛋白(EA)以还原氨基法偶联,Sepharose CL-4B纯化。制备以MenA PS-EA为包被抗原的A群脑膜炎奈瑟菌多糖IgG抗体的ELISA检测试剂,考察试剂的精密性和稳定性,并与血清杀菌力试验(SBA)比较。结果纯化的MenA PS-EA经高效液相色谱检测,纯度为81.50%;以MenA PS-EA为包被抗原的ELISA检测试剂精密性和稳定性良好;将该试剂与SBA法比较,其敏感性为96.91%,特异性为90.00%,一致性为95.83%。两种检测方法之间差异无显著意义。结论以纯化MenA PS-EA作为包被抗原建立的A群脑膜炎奈瑟菌多糖特异性IgG抗体ELISA检测试剂可用于检测多糖IgG抗体,为进一步研究及开发细菌多糖类抗体诊断试剂提供参考。 展开更多
关键词 a群脑膜炎奈瑟菌 多糖 IgG抗体 卵清蛋白 偶联物 ELISa试剂
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ELISA法和杀菌力试验测定健康人血清中A群Nm抗体的比较 被引量:6
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作者 徐丽 王君 +3 位作者 康殿财 胡绪敬 王喜臣 何伟 《疾病监测》 CAS 1998年第10期365-367,共3页
为了比较测定A群脑膜炎奈瑟氏菌(Nm)抗体的方法,从甘南县采取的129份健康者血清进行了ELISA测定,当利用A群Nm的荚膜多糖(CPS)或它的菌体作为包被抗原进行ELISA测定时,A群Nm抗体的阳性率分别为80.6... 为了比较测定A群脑膜炎奈瑟氏菌(Nm)抗体的方法,从甘南县采取的129份健康者血清进行了ELISA测定,当利用A群Nm的荚膜多糖(CPS)或它的菌体作为包被抗原进行ELISA测定时,A群Nm抗体的阳性率分别为80.6%和69.0%,抗体几何平均滴度(GMT)分别为1∶6.38与1∶5.46。另外,对量多的46份血清同时进行了杀菌力试验与ELISA,对A群Nm杀菌抗体的阳性率为67.4%,GMT为1∶9.16。当利用上述CPS或菌体作为包被抗原时,ELISA测定的抗体阳性率分别为73.9%和71.7%,它们的GMT分别为1∶7.53和1∶7.20。总的来说,ELISA测定的健康者血清中A群Nm抗体的阳性率与GMT和杀菌力试验的结果近似。 展开更多
关键词 a群Nm ELISa 杀菌力试验 抗体阳性率和GMT
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脑膜炎奈瑟菌ABC血清群的PCR快速诊断 被引量:2
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作者 徐亚军 郭宗琪 +1 位作者 罗隆泽 刘衡川 《现代预防医学》 CAS 北大核心 2008年第19期3774-3776,共3页
[目的]建立特异、敏感、快速的脑膜炎奈瑟菌检测方法。[方法]分别以Nm保守ctrA基因、荚膜表达基因orf-2和siaD基因设计引物,根据PCR扩增的特异性产物对Nm进行鉴定与分群。[结果]PCR扩增NmctrA基因得到111bp的特异性产物,非Nm菌株结果为... [目的]建立特异、敏感、快速的脑膜炎奈瑟菌检测方法。[方法]分别以Nm保守ctrA基因、荚膜表达基因orf-2和siaD基因设计引物,根据PCR扩增的特异性产物对Nm进行鉴定与分群。[结果]PCR扩增NmctrA基因得到111bp的特异性产物,非Nm菌株结果为阴性;再以PCR扩增orf-2和siaD基因,分别得到大小400bp(A群)、450bp(B群)、250bp(C群)的特异性片断。对60株Nm试验菌进行PCR鉴定,其结果与血清学分型结果一致。[结论]所建立方法可用于Nm的快速诊断。 展开更多
关键词 脑膜炎 PCR 脑膜炎奈瑟菌 诊断
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宁波市A群脑膜炎奈瑟菌药物敏感性监测分析 被引量:1
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作者 金春光 徐景野 +1 位作者 杨元斌 石优章 《中国热带医学》 CAS 2007年第3期401-402,共2页
目的了解宁波市A群脑膜炎奈瑟菌对常用抗生素的敏感性,为流行性脑脊髓膜炎的预防与治疗提供科学依据。方法采用E—test法和KB法,对宁波市2004—2005年分离9株A群脑膜炎奈瑟菌进行药敏试验。结果9株A群脑膜炎奈瑟菌对6种治疗药物青霉... 目的了解宁波市A群脑膜炎奈瑟菌对常用抗生素的敏感性,为流行性脑脊髓膜炎的预防与治疗提供科学依据。方法采用E—test法和KB法,对宁波市2004—2005年分离9株A群脑膜炎奈瑟菌进行药敏试验。结果9株A群脑膜炎奈瑟菌对6种治疗药物青霉素,氨苄西林,头孢曲松,头孢噻肟,美洛培南,氯霉素均敏感,6种预防用药阿奇霉素,米诺环素,萘啶酸、环丙沙星,复方SMZ和利福平中,阿奇霉素敏感,88、9%米诺环素敏感,66.7%利福平敏感,对萘啶酸、环丙沙星,复方SMZ均耐药。结论宁波市2004—2005年分离的流脑菌株对萘啶酸、环丙沙星,复方SMZ已产生耐药性,在当前防治流脑时应慎重使用。提示应加强脑膜炎奈瑟菌监测,合理选择抗生素,为预防和控制提供依据。 展开更多
关键词 流行性脑脊髓膜炎 a群脑膜炎萘瑟菌 药物敏感性
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A群流脑多糖疫苗免疫效果观察 被引量:1
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作者 张欣强 邓志爱 +2 位作者 周秀珍 李孝权 李钏华 《热带医学杂志》 CAS 2007年第10期1017-1019,共3页
目的比较A群流脑多糖疫苗接种前后人群的特异性抗体水平情况,评价免疫效果。方法以广州大学城某工地工人和某学院在校学生为研究对象,采用酶联免疫吸附试验对工地工人32人,学生147人在A群流脑多糖疫苗接种前以及接种20d后采集的血清抗... 目的比较A群流脑多糖疫苗接种前后人群的特异性抗体水平情况,评价免疫效果。方法以广州大学城某工地工人和某学院在校学生为研究对象,采用酶联免疫吸附试验对工地工人32人,学生147人在A群流脑多糖疫苗接种前以及接种20d后采集的血清抗体进行检测。结果接种A群多糖疫苗20d后,工地工人抗体阳性率由接种前的18.75%提高到87.50%,GMT由2.65提高到21.60;学生抗体阳性率由接种前的41.50%提高到80.95%,GMT由4.21提高到15.85,统计分析显示接种前后抗体阳性率、GMT之间差异有显著性意义(P<0.001)。结论发生流脑疫情时对特定区域人群进行疫苗接种能迅速提高人群的整体抗体水平,有利于保护易感人群,防止疫情进一步蔓延。 展开更多
关键词 多糖疫苗 a群脑膜炎奈瑟氏菌 流行性脑脊髓膜炎
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我国A群脑膜炎奈瑟氏菌的克隆群体结构与流行病学意义 被引量:2
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作者 李新武 胡绪敬 +4 位作者 高立慧 奚文龙 计银铎 徐丽 胡真 《中国公共卫生学报》 1991年第4期217-220,共4页
应用多位点酶电泳技术对从我国17个省市搜集的200株A群脑膜炎奈瑟氏菌(Nm)进行了克隆群体结构分(?)。结果表明,可将200株A群Nm分为23个电泳型(ET),7个克隆群,其中Ⅳ克隆群和Ⅴ克隆群为优势克隆群,两者的遗传距离为0.53。自60年代以来,... 应用多位点酶电泳技术对从我国17个省市搜集的200株A群脑膜炎奈瑟氏菌(Nm)进行了克隆群体结构分(?)。结果表明,可将200株A群Nm分为23个电泳型(ET),7个克隆群,其中Ⅳ克隆群和Ⅴ克隆群为优势克隆群,两者的遗传距离为0.53。自60年代以来,每次流脑流行周期均以一种克隆群为主,如60年代和80年代主要由Ⅳ克隆群引起流行,分别占同时期菌株数的85.7%和82.4%;70年代的流行主要由Ⅴ克隆群引起,占该期间菌株数的88.4%。优势克隆群优势十分明显,流行时间长,地区分布广,而且不同周期A群Nm优势克隆群的变迁与其优势亚型的变化基本吻合。我国A群Nm的优势克隆群及优势亚型在流脑不同流行周期内皆显示了周期性变换的特征。 展开更多
关键词 脑膜炎奈氏菌 克隆群 流行病学
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广州某大学城建筑工地A群流行性脑脊髓膜炎暴发的调查处理分析 被引量:1
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作者 许晓茵 秦小洁 +1 位作者 苏宁 李伟强 《医学动物防制》 2007年第1期9-10,共2页
目的:查明该岛建筑工地流行性脑脊髓膜炎局部暴发的因素。方法:用统一调查表逐例可疑流脑病例进行调查,常规脑脊液涂片检测革兰氏阴性双球菌,分离流脑脑膜炎奈瑟氏菌。结果16例以男性为主、年龄在16岁-54岁、无流脑疫苗免疫史的外地农民... 目的:查明该岛建筑工地流行性脑脊髓膜炎局部暴发的因素。方法:用统一调查表逐例可疑流脑病例进行调查,常规脑脊液涂片检测革兰氏阴性双球菌,分离流脑脑膜炎奈瑟氏菌。结果16例以男性为主、年龄在16岁-54岁、无流脑疫苗免疫史的外地农民工,居住在人均不足5平方米的拥挤宿舍内,引起局部暴发。结论:由于发现及时,处理措施到位,未造成病例死亡和疫情大面积扩散。为防止农民工出现流脑暴发疫情,建议有关部门在农民工招工、务工前接种流脑疫苗。 展开更多
关键词 流行性脑脊髓膜炎 暴发 分析
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Meningococcal disease, a clinical and epidemiological review 被引量:1
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作者 Rodrigo Siqueira Batista Andreia Patricia Gomes +4 位作者 Jorge Luiz Dutra Gazineo Paulo Sergio Balbino Miguel Luiz Alberto Santana Lisa Oliveira Mauro Geller 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2017年第11期1019-1029,共11页
Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high r... Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. In Brazil, it is endemic with occasional outbreaks, epidemics and sporadic cases occurring throughout the year, especially in the winter. The major epidemics of the disease occurred in Brazil in the 70's caused by serogroups A and C. Serogroups B, C and Y represent the majority of cases in Europe, the Americas and Australia. However, there has been a growing increase in serogroup W in some areas. The pathogen transmission happens for respiratory route(droplets) and clinically can lead to meningitis and sepsis(meningococcemia). The treatment is made with antimicrobial and supportive care. For successful prevention, we have some measures like vaccination, chemoprophylaxis and droplets' precautions. In this review, we have described and clarify clinical features of the disease caused by N. meningitidis regarding its relevance for healthcare professionals. 展开更多
关键词 neisseria meningitidis Bacterial infection Meningococcal disease
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Fatal meningococcal meningitis in a 2-year-old child:A case report 被引量:1
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作者 Aleksander Mularski Czesław Żaba 《World Journal of Clinical Cases》 SCIE 2019年第5期636-641,共6页
BACKGROUND In fatal cases of meningococcal septicemia, bacteriological diagnosis may not be straightforward due to postmortem replication and relocation of endogenic microflora. In medicolegal practice, aside from rou... BACKGROUND In fatal cases of meningococcal septicemia, bacteriological diagnosis may not be straightforward due to postmortem replication and relocation of endogenic microflora. In medicolegal practice, aside from routine autopsy and histopathology, also other diagnostic methods, such as microbiological tests,immunohistochemistry and polymerase chain reaction(PCR), are used to examine body fluids and tissues.CASE SUMMARY We present the case of sudden death in a 2-year-old child. The patient died approximately 30 min after hospital admission before any routine diagnostic procedures were undertaken. Presence of whole-body rash and fulminant course of the disease raised suspicion of meningococcal septicemia. An autopsy was performed seven days after death when the body showed the signs of late postmortem decomposition. No etiological factor of septicemia could be identified based on macro-and microscopic findings. However, PCR demonstrated the presence of genetic material of group W Neisseria meningitidis in patient's cerebrospinal fluid and blood.CONCLUSION Microbiological PCR should be conducted postmortem whenever a specific etiological factor could not be identified with conventional methods. 展开更多
关键词 Meningococcal infection Molecular microbiology Waterhouse-Friderichsen syndrome neisseria meningitidis aUTOPSY Cerebrospinal fluid Case report
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