Main observation and conclusion The enzyme AbyU catalyses a Diels-Alder(DA)reaction during abyssomicin C biosynthesis.In this study,AbyU is shown to convert the native substrate of another Diels-Alderase(DAase),AbmU,t...Main observation and conclusion The enzyme AbyU catalyses a Diels-Alder(DA)reaction during abyssomicin C biosynthesis.In this study,AbyU is shown to convert the native substrate of another Diels-Alderase(DAase),AbmU,to a new abyssomicin derivative,abyssomicin 7.展开更多
基金This work was supported by the China NSF(Nos.31670087 and U1706206)the Natural Key Research and Development Program of China(No.2019YFC0312500)+5 种基金the Key Special Project for Introduced Talents Team of Southern Marine Science and Engi-neering Guangdong Laboratory(Guangzhou,No.GML2019ZD0406)the Guangdong NSF(No.2016A030312014)the Guangdong Local Innovation Team Program(No.2019BT02Y262)the Pearl River S&T Nova Program of Guangzhou No.201806010109)the CAS(No.XDA13020302-2)the Guangdong Provincial-Level Special Funds for Promoting High-quality Economic Development(No.2020032).
文摘Main observation and conclusion The enzyme AbyU catalyses a Diels-Alder(DA)reaction during abyssomicin C biosynthesis.In this study,AbyU is shown to convert the native substrate of another Diels-Alderase(DAase),AbmU,to a new abyssomicin derivative,abyssomicin 7.
