Perinatal hypoxic-ischemic-encephalopathy significantly contributes to neonatal death and life-long disability such as cerebral palsy. Advances in signal processing and machine learning have provided the research comm...Perinatal hypoxic-ischemic-encephalopathy significantly contributes to neonatal death and life-long disability such as cerebral palsy. Advances in signal processing and machine learning have provided the research community with an opportunity to develop automated real-time identification techniques to detect the signs of hypoxic-ischemic-encephalopathy in larger electroencephalography/amplitude-integrated electroencephalography data sets more easily. This review details the recent achievements, performed by a number of prominent research groups across the world, in the automatic identification and classification of hypoxic-ischemic epileptiform neonatal seizures using advanced signal processing and machine learning techniques. This review also addresses the clinical challenges that current automated techniques face in order to be fully utilized by clinicians, and highlights the importance of upgrading the current clinical bedside sampling frequencies to higher sampling rates in order to provide better hypoxic-ischemic biomarker detection frameworks. Additionally, the article highlights that current clinical automated epileptiform detection strategies for human neonates have been only concerned with seizure detection after the therapeutic latent phase of injury. Whereas recent animal studies have demonstrated that the latent phase of opportunity is critically important for early diagnosis of hypoxic-ischemic-encephalopathy electroencephalography biomarkers and although difficult, detection strategies could utilize biomarkers in the latent phase to also predict the onset of future seizures.展开更多
Alongside clinical achievements,experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ ischemic e...Alongside clinical achievements,experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ ischemic encephalopathy (HIE).Due to the reasonably fair degree of flexibility with experiments,most of the research around HIE in the literature has been largely concerned with the neurodevelopmental outcome or how the frequency and duration of HI seizures could relate to the severity of perinatal brain injury,following HI insult.This survey concentrates on how EEG experimental studies using asphyxiated animal models (in rodents,piglets,sheep and non-human primate monkeys) provide a unique opportunity to examine from the exact time of HI event to help gain insights into HIE where human studies become difficult.展开更多
目的:探讨新生儿缺氧缺血性脑病(hypoxic-ischem ic encephalopathy,H IE)血浆肾上腺髓质素(ad-renom edu llin,ADM)动态变化及临床意义。方法:采用非平衡放射免疫分析动态测定32例H IE新生儿生后24h、3d、7d血浆ADM水平,并以30例正常...目的:探讨新生儿缺氧缺血性脑病(hypoxic-ischem ic encephalopathy,H IE)血浆肾上腺髓质素(ad-renom edu llin,ADM)动态变化及临床意义。方法:采用非平衡放射免疫分析动态测定32例H IE新生儿生后24h、3d、7d血浆ADM水平,并以30例正常新生儿为正常对照组。结果:H IE组生后24h、3d、7d ADM浓度分别为(139.58±37.86)pg/m l、(121.97±35.73)pg/m l和(97.25±21.27)pg/m l,三者间差异显著(P均<0.05);与对照组(87.49±15.00)pg/m l比较,生后24h、3d明显增高,有显著性差异(P均<0.05),而7d与对照组比较无差异(P>0.05)。结论:ADM参与新生儿H IE的病理过程,且可能是机体在缺氧缺血性脑损伤时发生的一种自我保护机制。展开更多
目的分析新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)的国内外研究现状及热点。方法利用CiteSpace软件对国内外HIE相关文献的年份、作者、机构、关键词等进行分析。结果检索CNKI和Web of Science(WOS)数据库分别获得中...目的分析新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)的国内外研究现状及热点。方法利用CiteSpace软件对国内外HIE相关文献的年份、作者、机构、关键词等进行分析。结果检索CNKI和Web of Science(WOS)数据库分别获得中文核心期刊文献1630篇,英文文献3143篇。中文文献发文量在2004年达高峰,随后呈波动下降,以韩玉昆发文量最多,南京中医药大学发文最早,各机构间无合作关系;高频关键词有“新生儿”“HIE”“脑缺血”“高压氧”等。作者Seetha Shankaran及机构Johns Hopkins大学的英文发文量最多,各机构间有一定的合作关系,发文量从2000年波动上升,2020年发文量最高;高频关键词有“HIE”“脑损伤”“新生儿”“围产期窒息”“低温”等。结论国内外对HIE研究主要集中在病因、辅助检查、治疗及预后等方面,虽然专注点有所差异,但亚低温、高压氧治疗是共同热点。国内机构与研究者之间应加强合作,提升专注度,拓宽研究领域及深度。展开更多
基金supported by the Auckland Medical Research Foundation,No.1117017(to CPU)
文摘Perinatal hypoxic-ischemic-encephalopathy significantly contributes to neonatal death and life-long disability such as cerebral palsy. Advances in signal processing and machine learning have provided the research community with an opportunity to develop automated real-time identification techniques to detect the signs of hypoxic-ischemic-encephalopathy in larger electroencephalography/amplitude-integrated electroencephalography data sets more easily. This review details the recent achievements, performed by a number of prominent research groups across the world, in the automatic identification and classification of hypoxic-ischemic epileptiform neonatal seizures using advanced signal processing and machine learning techniques. This review also addresses the clinical challenges that current automated techniques face in order to be fully utilized by clinicians, and highlights the importance of upgrading the current clinical bedside sampling frequencies to higher sampling rates in order to provide better hypoxic-ischemic biomarker detection frameworks. Additionally, the article highlights that current clinical automated epileptiform detection strategies for human neonates have been only concerned with seizure detection after the therapeutic latent phase of injury. Whereas recent animal studies have demonstrated that the latent phase of opportunity is critically important for early diagnosis of hypoxic-ischemic-encephalopathy electroencephalography biomarkers and although difficult, detection strategies could utilize biomarkers in the latent phase to also predict the onset of future seizures.
基金supported by the Auckland Medical Research Foundation,No.1117017(to CPU)
文摘Alongside clinical achievements,experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ ischemic encephalopathy (HIE).Due to the reasonably fair degree of flexibility with experiments,most of the research around HIE in the literature has been largely concerned with the neurodevelopmental outcome or how the frequency and duration of HI seizures could relate to the severity of perinatal brain injury,following HI insult.This survey concentrates on how EEG experimental studies using asphyxiated animal models (in rodents,piglets,sheep and non-human primate monkeys) provide a unique opportunity to examine from the exact time of HI event to help gain insights into HIE where human studies become difficult.
