Histamine in food has attracted widespread attention due to the potential toxicity and associated health risk.However,its influences on immunological components,especially the function of key immune cells,are still po...Histamine in food has attracted widespread attention due to the potential toxicity and associated health risk.However,its influences on immunological components,especially the function of key immune cells,are still poorly known.In this work,we explored the effects of exogenous histamine on the function of key immune cells such as intestinal epithelial cells,dendritic cells,and T cells.The results showed that histamine could affect the expression of allergy-related genes in CMT93 cells at a high dose of histamine.Moreover,it’s found that histamine could cause an imbalance in the levels of relevant immune factors secreted by dendritic cells and T cells,especially those related to allergy.At the same time,the proportion of MHC class IIpositive dendritic cells and the proportion of T helper 2(Th2)cells in CD4^(+)T cells increased after histamine stimulation.We concluded that the presence of a certain level of histamine in food may affect the expression of allergy-related cytokines,disrupt the balance of the immune homeostasis,and potentially lead to adverse immune reactions.This work demonstrated the importance of including the estimation of histamine’s immune safety in aquatic products rather than merely considering the potential risk of food poisoning.展开更多
Objective The custom-homebuilding company, Cosmic Garden Co. Ltd., located in Okayama City, Japan was established in 1997 and uses specific natural ore powder （SNOP） in wall materials and surveys customers in order ...Objective The custom-homebuilding company, Cosmic Garden Co. Ltd., located in Okayama City, Japan was established in 1997 and uses specific natural ore powder （SNOP） in wall materials and surveys customers in order to improve allergic symptoms. Methods To investigate the biological effects of SNOP, patients with a pollen allergy were recruited to stay in a room surrounded by cloth containing SNOP （CCSNOP）, and their symptoms and various biological parameters were compared with those of individuals staying in a room surrounded by control non-woven cloth （NWC）. Each stay lasted 60 min. Before and immediately after the stay, a questionnaire regarding allergic symptoms, as well as POMS （Profile of Mood Status） and blood sampling, was performed. Post-stay minus pre-stay values were calculated and compared between CCSNOP and NWC groups. Results Results indicated that some symptoms, such as nasal obstruction and lacrimation, improved, and POMS evaluation showed that patients were calmer following a stay in CCSNOP. Relative eosinophils, non-specific Ig E, epidermal growth factor, monocyte chemotactic protein-I, and tumor necrosis factor-a increased following a stay in CCSNOP. Conclusion This ore powder improved allergic symptoms, and long-term monitoring involving 1 to 2 months may be necessary to fully explore the biological and physical effects of SNOP on allergic patients.展开更多
We examined IgE levels in 4,312 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 1998-2015. At the age often days, those with high IgE we...We examined IgE levels in 4,312 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 1998-2015. At the age often days, those with high IgE were given Colinfant Newborn （a lyophilized non-pathogenic strain of E. coli） for one month, three times weekly. At 15 months and three years we investigated the levels of IgE, IgA and IgG, and the incidence of illness and allergy. The results revealed that allergy and high umbilical IgE is strongly linked with family history （p 〈 0.001）. We also detected differences in seasonality, especially with regards to pollen allergies. About 80% of children treated with Colinfant had significantly reduced IgE and morbidity at 13-15 months and 3 years, and furthermore without any clinical signs of allergy. Surprisingly 20% of treated children did not have reduced IgE, and yet they did not have any clinical signs of allergy. Normalization of IgA and IgG was seen in 90% of treated subjects （p 〈 0.001）. These levels significantly are correlated with an almost negligible morbidity up to 4 years of life. Our study strongly suggests a positive effect of physiological E. coli on the microbiome of children as evidenced by a significantly reduced incidence of allergy and morbidity when applied early in life.展开更多
2011182 Modulation of RhoA/ROCK pathway on TLR-2 ligand-induced chemokine secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. LIANG Liuqin(梁柳琴),et al. Dept Rheumatol,1st Affil
2010408 The expression of CD73 in CD4+ regulatory T cells in patients with new-onset systemic lupus erythematosus.LI Dongmei(李冬梅), et al.Dept Rheumatol &Immunol, Anhui Med Univ Prov Hosp, Hefei 230001.Chin J In...2010408 The expression of CD73 in CD4+ regulatory T cells in patients with new-onset systemic lupus erythematosus.LI Dongmei(李冬梅), et al.Dept Rheumatol &Immunol, Anhui Med Univ Prov Hosp, Hefei 230001.Chin J Intern Med 2010;49(9):772 -775. Objective To investigate the展开更多
2015418 Expression and signifficance of 25-hydroxy vitamin D in rheumatic disease patients and the risk between it and cardiovascular disease.LI Jinchan(李金潺),et al.Dept Rheumatol&Immunol,2nd Hosp,Shanxi Med Uni...2015418 Expression and signifficance of 25-hydroxy vitamin D in rheumatic disease patients and the risk between it and cardiovascular disease.LI Jinchan(李金潺),et al.Dept Rheumatol&Immunol,2nd Hosp,Shanxi Med Univ,Taiyuan 030001.Chin J Rheumatol2015;19(9):611-613.展开更多
2014428 Analysis of traditional cardiovascular risk factors in patients with systemic lupus erythematosus.LIU Li(刘丽),et al.Dept Cardiol,PUMC Hosp,Beijing 100730.Chin J Cardiol 2014;42(9):753-758.Objective To evaluat...2014428 Analysis of traditional cardiovascular risk factors in patients with systemic lupus erythematosus.LIU Li(刘丽),et al.Dept Cardiol,PUMC Hosp,Beijing 100730.Chin J Cardiol 2014;42(9):753-758.Objective To evaluate the prevalence of hypertension,diabetes,dyslipidemia in systemic lupus erythematosus(SLE)patients,and to investigate the factors that affecting lipid levels in SLE patients.Methods A total of540 adult SLE patients hospitalized in Peking Union Medical College Hospital from March 2010 to展开更多
2009037 Passive transfer/of experimental autoimmune myasthenia gravis in rabbits with IgG of myasthenia gravis patients. LI Xiuhua(李秀华). et al. Neurol Dept, Tianjin Med Univ General Hosp, Tianjin 300052. Chin J Me...2009037 Passive transfer/of experimental autoimmune myasthenia gravis in rabbits with IgG of myasthenia gravis patients. LI Xiuhua(李秀华). et al. Neurol Dept, Tianjin Med Univ General Hosp, Tianjin 300052. Chin J Ment Nerv Dis 2009;35(1):7-10. Objective To create experimental autoimmune myasthenia gravis (EAMG) rabbits by passive transfer the IgG.展开更多
2015285 Roleβ2-adrenergic receptor polymorphisms in prognosis of myasthenia gravis with other autoimmune diseases.WANG Lili(王莉莉),et al.Dept Neurol,Beijing Shijitan Hosp,Capital Med Univ,Beijing 100038.Chin J Neuro...2015285 Roleβ2-adrenergic receptor polymorphisms in prognosis of myasthenia gravis with other autoimmune diseases.WANG Lili(王莉莉),et al.Dept Neurol,Beijing Shijitan Hosp,Capital Med Univ,Beijing 100038.Chin J Neurol 2015;48(5):390-393.Objective To explore the correlation ofβ2-adrenergic receptor(β2-AR)polymorphisms(Argl6Gly)with the prognosis of myasthenia gravis(MG)complicated with other autoimmune diseases.Methods Among the 75MG patients in analysis,17 cases complicated with展开更多
2010176 Interactions between susceptible genes and risk environmental factors in Chinese females with systemic lupus erythematosus.PENG Chunlin(彭春林),et al.Dept Epidemiol,Sch Public Health,Fudan Univ,Shanghai 200032...2010176 Interactions between susceptible genes and risk environmental factors in Chinese females with systemic lupus erythematosus.PENG Chunlin(彭春林),et al.Dept Epidemiol,Sch Public Health,Fudan Univ,Shanghai 200032.Chin J Prev Med 2010;44(2):144-149.展开更多
2018028 The clinical characteristics, diagnosis and treatment of patients with gout in China. LUO Hui （罗卉）, et al. Dept Rheumatol, PUMC ＆ CAMS, Beijing 100730. Chin J Intern Med 2018; 27（ 1 ） ：27-31. Objective...2018028 The clinical characteristics, diagnosis and treatment of patients with gout in China. LUO Hui （罗卉）, et al. Dept Rheumatol, PUMC ＆ CAMS, Beijing 100730. Chin J Intern Med 2018; 27（ 1 ） ：27-31. Objective To investigate the demographic characteristics, clinical features, diagnosis and treatment of patients with gout in China. Methods Clinical data of 6 814 patients with gout from 100 hospitals in 27 provinces, municipalities or autonomous regions in China were collected and analyzed. Results （1） The ratio of male to female in patients with gout was 14. 7： 1.展开更多
基金financially supported by the Key Project of Zhejiang Provincial Natural Science Foundation of China(LZ22C200003)the National Natural Science Foundation of China(32072290)。
文摘Histamine in food has attracted widespread attention due to the potential toxicity and associated health risk.However,its influences on immunological components,especially the function of key immune cells,are still poorly known.In this work,we explored the effects of exogenous histamine on the function of key immune cells such as intestinal epithelial cells,dendritic cells,and T cells.The results showed that histamine could affect the expression of allergy-related genes in CMT93 cells at a high dose of histamine.Moreover,it’s found that histamine could cause an imbalance in the levels of relevant immune factors secreted by dendritic cells and T cells,especially those related to allergy.At the same time,the proportion of MHC class IIpositive dendritic cells and the proportion of T helper 2(Th2)cells in CD4^(+)T cells increased after histamine stimulation.We concluded that the presence of a certain level of histamine in food may affect the expression of allergy-related cytokines,disrupt the balance of the immune homeostasis,and potentially lead to adverse immune reactions.This work demonstrated the importance of including the estimation of histamine’s immune safety in aquatic products rather than merely considering the potential risk of food poisoning.
基金the Kirameki Creation Fund from the Okayama Prefecture Industrial Promotion Foundation from January to September,2014
文摘Objective The custom-homebuilding company, Cosmic Garden Co. Ltd., located in Okayama City, Japan was established in 1997 and uses specific natural ore powder （SNOP） in wall materials and surveys customers in order to improve allergic symptoms. Methods To investigate the biological effects of SNOP, patients with a pollen allergy were recruited to stay in a room surrounded by cloth containing SNOP （CCSNOP）, and their symptoms and various biological parameters were compared with those of individuals staying in a room surrounded by control non-woven cloth （NWC）. Each stay lasted 60 min. Before and immediately after the stay, a questionnaire regarding allergic symptoms, as well as POMS （Profile of Mood Status） and blood sampling, was performed. Post-stay minus pre-stay values were calculated and compared between CCSNOP and NWC groups. Results Results indicated that some symptoms, such as nasal obstruction and lacrimation, improved, and POMS evaluation showed that patients were calmer following a stay in CCSNOP. Relative eosinophils, non-specific Ig E, epidermal growth factor, monocyte chemotactic protein-I, and tumor necrosis factor-a increased following a stay in CCSNOP. Conclusion This ore powder improved allergic symptoms, and long-term monitoring involving 1 to 2 months may be necessary to fully explore the biological and physical effects of SNOP on allergic patients.
文摘We examined IgE levels in 4,312 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 1998-2015. At the age often days, those with high IgE were given Colinfant Newborn （a lyophilized non-pathogenic strain of E. coli） for one month, three times weekly. At 15 months and three years we investigated the levels of IgE, IgA and IgG, and the incidence of illness and allergy. The results revealed that allergy and high umbilical IgE is strongly linked with family history （p 〈 0.001）. We also detected differences in seasonality, especially with regards to pollen allergies. About 80% of children treated with Colinfant had significantly reduced IgE and morbidity at 13-15 months and 3 years, and furthermore without any clinical signs of allergy. Surprisingly 20% of treated children did not have reduced IgE, and yet they did not have any clinical signs of allergy. Normalization of IgA and IgG was seen in 90% of treated subjects （p 〈 0.001）. These levels significantly are correlated with an almost negligible morbidity up to 4 years of life. Our study strongly suggests a positive effect of physiological E. coli on the microbiome of children as evidenced by a significantly reduced incidence of allergy and morbidity when applied early in life.
文摘2011182 Modulation of RhoA/ROCK pathway on TLR-2 ligand-induced chemokine secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. LIANG Liuqin(梁柳琴),et al. Dept Rheumatol,1st Affil
文摘2010408 The expression of CD73 in CD4+ regulatory T cells in patients with new-onset systemic lupus erythematosus.LI Dongmei(李冬梅), et al.Dept Rheumatol &Immunol, Anhui Med Univ Prov Hosp, Hefei 230001.Chin J Intern Med 2010;49(9):772 -775. Objective To investigate the
文摘2015418 Expression and signifficance of 25-hydroxy vitamin D in rheumatic disease patients and the risk between it and cardiovascular disease.LI Jinchan(李金潺),et al.Dept Rheumatol&Immunol,2nd Hosp,Shanxi Med Univ,Taiyuan 030001.Chin J Rheumatol2015;19(9):611-613.
文摘2014428 Analysis of traditional cardiovascular risk factors in patients with systemic lupus erythematosus.LIU Li(刘丽),et al.Dept Cardiol,PUMC Hosp,Beijing 100730.Chin J Cardiol 2014;42(9):753-758.Objective To evaluate the prevalence of hypertension,diabetes,dyslipidemia in systemic lupus erythematosus(SLE)patients,and to investigate the factors that affecting lipid levels in SLE patients.Methods A total of540 adult SLE patients hospitalized in Peking Union Medical College Hospital from March 2010 to
文摘2009037 Passive transfer/of experimental autoimmune myasthenia gravis in rabbits with IgG of myasthenia gravis patients. LI Xiuhua(李秀华). et al. Neurol Dept, Tianjin Med Univ General Hosp, Tianjin 300052. Chin J Ment Nerv Dis 2009;35(1):7-10. Objective To create experimental autoimmune myasthenia gravis (EAMG) rabbits by passive transfer the IgG.
文摘2015285 Roleβ2-adrenergic receptor polymorphisms in prognosis of myasthenia gravis with other autoimmune diseases.WANG Lili(王莉莉),et al.Dept Neurol,Beijing Shijitan Hosp,Capital Med Univ,Beijing 100038.Chin J Neurol 2015;48(5):390-393.Objective To explore the correlation ofβ2-adrenergic receptor(β2-AR)polymorphisms(Argl6Gly)with the prognosis of myasthenia gravis(MG)complicated with other autoimmune diseases.Methods Among the 75MG patients in analysis,17 cases complicated with
文摘2010176 Interactions between susceptible genes and risk environmental factors in Chinese females with systemic lupus erythematosus.PENG Chunlin(彭春林),et al.Dept Epidemiol,Sch Public Health,Fudan Univ,Shanghai 200032.Chin J Prev Med 2010;44(2):144-149.
文摘2018028 The clinical characteristics, diagnosis and treatment of patients with gout in China. LUO Hui （罗卉）, et al. Dept Rheumatol, PUMC ＆ CAMS, Beijing 100730. Chin J Intern Med 2018; 27（ 1 ） ：27-31. Objective To investigate the demographic characteristics, clinical features, diagnosis and treatment of patients with gout in China. Methods Clinical data of 6 814 patients with gout from 100 hospitals in 27 provinces, municipalities or autonomous regions in China were collected and analyzed. Results （1） The ratio of male to female in patients with gout was 14. 7： 1.
