A Meta analysis of characteristics of median nerve and sural nerve injury inpatients with diabetic peripheral neuropathy

Objective： A meta-analysis of randomized trials was performed to assess the injured degree of median nerve andsural nerve in patients with diabetic peripheral neuropathy （DPN）. Methods： we searched Pubmed Database, ChinaBiomedical Literature Database, VIP Database, ChinaNet for studies. Then evaluated these studies in order to findthe researches in line with the requirements of the study; Each relevant research was carefully read to extractrelevant data; The current perception threshold （CPT） value of median nerve and sural nerve were compared at2000Hz, 250Hz and 5Hz between patients with DPN and the normal control group. Results： Finally 10 articles thatmeet the standards were included, with 1054 cases in the patient group and 719 cases in the normal group. The CPTvalues of median nerve and sural nerve at 2000 Hz, 250 Hz and 5 Hz of patients group were higher than those ofnormal control group （P 〈0.05 for all）. Conclusion： Systematic reviews showed that the sensitivity of the mediannerve and sural nerve in DPN patients was generally reduced. Sensory nerve quantitative detector could detectnerve damage early, accurately and monitor the effect treatment in patients with DPN.

Macular thickness as a predictor of loss of visual sensitivity in ethambutol-induced optic neuropathy

Ethambutol is a common cause of drug-related optic neuropathy.Prediction of the onset of ethambutol-induced optic neuropathy and consequent drug withdrawal may be an effective method to stop visual loss.Previous studies have shown that structural injury to the optic nerve occurred earlier than the damage to visual function.Therefore,we decided to detect structural biomarkers marking visual field loss in early stage ethambutol-induced optic neuropathy.The thickness of peripapillary retinal nerve fiber layer,macular thickness and visual sensitivity loss would be observed in 11 ethambutol-induced optic neuropathy patients（22 eyes） using optical coherence tomography.Twenty-four healthy age-and sex-matched participants（48 eyes） were used as controls.Results demonstrated that the temporal peripapillary retinal nerve fiber layer thickness and average macular thickness were thinner in patients with ethambutol-induced optic neuropathy compared with healthy controls.The average macular thickness was strongly positively correlated with central visual sensitivity loss（r2=0.878,P=0.000）.These findings suggest that optical coherence tomography can be used to efficiently screen patients.Macular thickness loss could be a potential factor for predicting the onset of ethambutol-induced optic neuropathy.