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Adherence in Patients with Type 2 Diabetes and Depression and the Role of Physician-Patient Relationship: A Cross-Sectional Study
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作者 Nadine Mansour Nargis Albert Mohamed Khalil 《Open Journal of Psychiatry》 2023年第3期136-152,共17页
Background: Diabetes mellitus (DM) challenges health and quality of life of patients, families, and communities. Patients with comorbid depression are more likely to develop macrovascular and microvascular complicatio... Background: Diabetes mellitus (DM) challenges health and quality of life of patients, families, and communities. Patients with comorbid depression are more likely to develop macrovascular and microvascular complications. The aim was to assess glycemic control and adherence in diabetic patients with comorbid depression. Further, the study evaluated the relationship between adherence and the physician-patient relationship. Methods: The study was conducted at Al-Agouza Family Medicine Center (AFMC) between February 2018 and March 2020. The included patients were between 35 - 80 years of age;had type 2 diabetes with hemoglobin A1c (HbA1c) ≥ 6.5%, fasting plasma glucose ≥ 126 mg/dl, and scored between 11 - 30 on the Beck Depression Inventory (BDI). Logistic regression, chi-square, and analysis of variance (ANOVA) were used to assess the relationship between depression, adherence, physician-patient relationship, and other variables. Results: The study included 100 eligible patients with a median BDI score of 20 (10 - 30). The median diabetic panel for patients was FBS 188 (126 - 348) mg/dl, PPS 282.50 (162 - 448) mg/dl, and HbA1c 9.5 (6.6 - 14.0)%. Depression and regular follow-up visits were statistically associated with improvement of diabetes symptoms (p = 0.019). There was a significant relationship (p 0.001) between adherence, regular follow-up visits, and knowledge of DM. Further, there was a significant relationship between the physician-patient relationship and DM improvement (p = 0.047). Conclusion: Physician-patient relationship was paramount to improving adherence and positive diabetes care. Our findings suggest a shift to a physician-patient relationship model with mutual agreement on medical decisions is highly recommended. 展开更多
关键词 DEPRESSION Type 2 Diabetes ADHERENCE physician-patient relationship
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远志寡糖酯化合物的神经保护作用及初步构效关系研究 被引量:21
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作者 黄志雄 穆丽华 +2 位作者 赵海霞 封聚强 刘屏 《解放军药学学报》 CAS 2012年第5期377-380,384,共5页
目的研究远志中寡糖酯类化合物的神经保护作用和探讨化合物的初步构效关系。方法采用MTT法和BrdU标记法评价寡糖酯单体化合物对神经细胞的保护作用。结果在体外皮质酮诱导的SH-SY5Y神经细胞损伤模型上,化合物tenifoliside A、tenuifolio... 目的研究远志中寡糖酯类化合物的神经保护作用和探讨化合物的初步构效关系。方法采用MTT法和BrdU标记法评价寡糖酯单体化合物对神经细胞的保护作用。结果在体外皮质酮诱导的SH-SY5Y神经细胞损伤模型上,化合物tenifoliside A、tenuifoliose J、tenuifolioses A、1-o-(E)-Benzoyl-[3-o-(E)-Alphatolluyl]-β-D-fructofuranosy-(2→1)-[β-D-glu-copyranosyl-(1→2)]-α-D-gluc-opyranosid表现出了很好的神经保护作用,并呈一定的剂量依赖性。结论远志寡糖酯类化合物对皮质酮诱导损伤的SH-SY5Y神经细胞有保护作用,其保护作用强弱与化合物类型及其浓度,化合物的母核结构,取代基位置和取代基种类有关。 展开更多
关键词 远志 寡糖酯 SH—SY5Y细胞 神经保护 构效关系
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Ameliorating Effects of Thyroxine and Atropine in Phosphamidon Intoxicated Chick Embryos
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作者 CHATTALI GHOSH AND J.N.MEDDA (Department of Zoology, Burdwan University, Burdwan 713104,West Bengal, INDIA)J.N.MEDDA (To whom all corespondences should be addressed.E-mail:zoojnm@burdwan.ernet.in.) 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1999年第1期34-42,共9页
The effects of thyroxine and atropine in ameliorating phosphamidon intoxication in chick embryos was studied. Treatment of phosphamidon significantly enhanced the moriality and abnormalityrates, decreased the average ... The effects of thyroxine and atropine in ameliorating phosphamidon intoxication in chick embryos was studied. Treatment of phosphamidon significantly enhanced the moriality and abnormalityrates, decreased the average body weights, and cholinesterase activity in chick embryos. When thyroxine was administered to the phosphamidon intoxicated embryos, the above parameters changedsignificantly, indicating an ameliorating effect of thyroxine against phosphamidon intoxication in chick embryos. The combined thyroxine and atropine therapy did not further improve the ameliorating effect. Since in many respects chick embryo development parallels that of mammalian embryos,a short-term use of thyroxine as a protective agent against organophosphate toxicity might be useful 展开更多
关键词 ANIMALS ATROPINE Body Weight Central nervous System Chick Embryo Cholinesterase Inhibitors CHOLINESTERASES Dose-Response relationship Drug INSECTICIDES Kidney Liver Phosphamidon THYROXINE
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Smartphone Application WeChat for Clinical Follow-up of Discharged Patients with Head and Neck Tumors: A Randomized Controlled Trial 被引量:33
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作者 Ke-Xing Lyu Jing Zhao +8 位作者 Bin Wang Guan-Xia Xiong Wei-Qiang Yang Qi-Hong Liu Xiao-Lin Zhu Wei Sun Ai-Yun Jiang Wei-Ping Wen Wen-Bin Lei 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第23期2816-2823,共8页
Background: Nowadays, social media tools such as short message service, Twitter, video, and web-based systems are more and more used in clinical follow-up, making clinical follow-up much more time- and cost-effective... Background: Nowadays, social media tools such as short message service, Twitter, video, and web-based systems are more and more used in clinical follow-up, making clinical follow-up much more time- and cost-effective than ever before. However, as the most popular social media in China, little is known about the utility of smartphone WeChat application in follow-up. In this study, we aimed to investigate the feasibility and superiority of WeChat application in clinical follow-up. Methods: A total of 108 patients diagnosed with head and neck tumor were randomized to WeChat follow-up (WFU) group or telephone follow-up (TFU) group for 6-month follow-up. The follow-ups were delivered by WeChat or telephone at 2 weeks, 1, 2, 3, and 6 months to the patients after being discharged. The study measurements were time consumption for follow-up delivery, total economic cost, lost-to-follow-up rate, and overall satisfaction for the follow-up method. Results: Time consumption in WFU group for each patient (23.36 ± 6.16 min) was significantly shorter than that in TFU group (42.89 ± 7.15 min) (P 〈 0.001 ); total economic cost in WFU group (RMB 90 Yuan) was much lower than that in TFU group (RMB 196 Yuan). Lost-to-follow-up rate in the WFU group was 7.02% (4/57) compared with TFU group, 9.80% (5/51 ), while no significance was observed (95% confidence interval [CI]: 0.176-2.740; P = 0.732). The overall satisfaction rate in WFU group was 94.34% (50/53) compared with 80.43% (37/46) in TFU group (95% CI: 0.057-0.067; P = 0.034). Conclusions: The smartphone WeChat application was found to be a viable option for follow-up in discharged patients with head and neck tumors. WFU was time-effective, cost-effective, and convenient in communication. This doctor-led follow-up model has the potential to establish a good physician-patient relationship by enhancing dynamic communications and providing individual health instructions. 展开更多
关键词 COMMUNICATION Lost-to-follow-up Head and Neck Neoplasms physician-patient relationship Social Media
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Changes in public trust in physicians: empirical evidence from China 被引量:4
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作者 Dahai Zhao Zhiruo Zhang 《Frontiers of Medicine》 SCIE CAS CSCD 2019年第4期504-510,共7页
Studies examining the trends in public trust in physicians have provided a considerable amount of valuable policy implications for policymakers compared with cross-sectional studies on this topic in many countries. Th... Studies examining the trends in public trust in physicians have provided a considerable amount of valuable policy implications for policymakers compared with cross-sectional studies on this topic in many countries. This study investigated changes in public trust in physicians in China based on two cross-sectional national surveys conducted in 2011 and 2016 and identified the determinants of these changes. The results indicated 83.4% of respondents in 20H reported trust or strong trust in physicians in China, which decreased to 64.2% by 2016. The results of ordinal logistic regression demonstrated that public trust in physicians in China had decreased significantly from 2011 to 2016 (P < 0.001) after adjusting for other independent variables. Selfreported health status, self-rated happiness, and self-identified social class were all associated positively with public trust in physicians in China. The results also confirmed that decreasing public satisfaction with the most recent treatment experience was the major determinant of decreasing public trust in physicians in China. The findings of this study suggest that decreasing public trust in physicians deserves considerable attention from national policymakers and that improving satisfaction with treatment experiences would be the most effective strategy for enhancing public trust in physicians in China. 展开更多
关键词 TRUST in PHYSICIANS PUBLIC TRUST physician-patient relationship health system performance
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